Sirtuin
Sirtuins are a conserved family of NAD+-dependent deacylases and class III histone deacetylases that couple cellular energy status to transcriptional and metabolic regulation, thereby influencing stress adaptation, genome maintenance, and cellular homeostasis[1][2]. Mechanistically, sirtuins respond to fluctuations in NAD+ availability and regulate pathways associated with oxidative stress resistance, mitochondrial function, DNA repair, and metabolic efficiency through deacylation of histone and non-histone protein targets[2][3][4]. These activities place sirtuins at the intersection of nutrient sensing and cellular responses to environmental and physiological perturbations, including fasting, caloric restriction, DNA damage, and redox imbalance[2][4]. In disease-relevant contexts and experimental models, altered sirtuin activity has been linked to aging-related functional decline, metabolic disorders, inflammation, and impaired mitochondrial homeostasis, making the family an important framework for mechanistic studies of age-associated pathophysiology[2][5]. Compared with related isoforms, mammalian SIRT1-SIRT7 display distinct subcellular localization and biological functions, with SIRT1, SIRT6, and SIRT7 enriched mainly in the nucleus, SIRT2 primarily localized in the cytoplasm, and SIRT3, SIRT4, and SIRT5 concentrated in mitochondria, supporting isoform-specific regulation of cellular processes[1][3]. For experimental applications, sirtuin-modulating compounds, including sirtuin-activating compounds and inhibitors such as nicotinamide, are widely used to investigate NAD+-dependent signaling networks and the contribution of individual sirtuin isoforms to metabolism, aging, and disease mechanisms[5][6].
References:
- [1]. Zhao L, et al. Sirtuins and their Biological Relevance in Aging and Age-Related Diseases. Aging Dis. 2020 Jul 23;11(4):927-945. [Content Brief]
- [2]. Imai S, et al. NAD+ and sirtuins in aging and disease. Trends Cell Biol. 2014 Aug;24(8):464-71. [Content Brief]
- [3]. Shahgaldi S, et al. A comprehensive review of Sirtuins: With a major focus on redox homeostasis and metabolism. Life Sci. 2021;282:119803.
- [4]. Imai S, et al. It takes two to tango: NAD+ and sirtuins in aging/longevity control. npj Aging Mech Dis. 2016;2:16017.
- [5]. Bonkowski MS, et al. Slowing ageing by design: the rise of NAD+ and sirtuin-activating compounds. Nat Rev Mol Cell Biol. 2016 Nov;17(11):679-690. [Content Brief]
- [6]. Wikipedia.
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Sirtuin Related Products (151)
Related Products (151)
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SIRT6 modulator-1
0 ImagesCat. No.: HY-186009CAS No.: 339156-78-4
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3-TYP (Standard)
0 ImagesCat. No.: HY-108331RCAS No.: 120241-79-43-TYP (Standard) is the analytical standard of 3-TYP (HY-108331). This product is intended for research and analytical applications. 3-TYP is an inhibitor of SIRT3 (IC50of 38 μM) and an inhibitor of Methionine Adenosyltransferase (MAT) 2 and Indoleamine 2,3-Dioxygenase (IDO). There may be many off-target sites for 3-TYP that need to be examined, such as NAD-dependent enzymes, including dehydrogenases.
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Salermide (Standard)
0 ImagesCat. No.: HY-101073RCAS No.: 1105698-15-4
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SIRT2-IN-15
0 ImagesCat. No.: HY-159126CAS No.: 312275-43-7SIRT2-IN-15 (compound 1) is a SIRT2 deacetylase and deamyloacylase inhibitor with IC50 7 and 37 μM, respectively.
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PROTAC Sirt2 Degrader-1 (Standard)
0 ImagesCat. No.: HY-103636RCAS No.: 2098487-75-1PROTAC Sirt2 Degrader-1 (Standard) is the analytical standard of PROTAC Sirt2 Degrader-1 (HY-103636). This product is intended for research and analytical applications. PROTAC Sirt2 Degrader-1 is a SirReal-based PROTAC, acts as a Sirt2 degrader, composed of a highly potent and isotype-selective Sirt2 inhibitor, a linker, and a bona fide Cereblon ligand for E3 ubiquitin ligase. PROTAC Sirt2 Degrader-1 shows an IC50 of 0.25 μM for Sirt2, with no effect on Sirt1/Sirt3 (IC50s>100 μM).
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SIRT1-IN-6
0 ImagesCat. No.: HY-174299CAS No.: 1174387-32-6
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Perindopril-d3 erbumine
0 ImagesCat. No.: HY-B0130ASSynonyms: Perindopril-d3 (tert-butylamine salt); S-9490-d3 erbuminePerindopril-d3 (erbumine) is deuterated labeled Perindopril (erbumine) (HY-B0130A). Perindopril erbumine is an angiotensin-converting enzyme inhibitor. Perindopril erbumine modulates NF-κB and STAT3 signaling and inhibits glial activation and neuroinflammation. Perindopril erbumine can be used for the research of Chronic Kidney Disease and high blood pressure.
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5-Heptadecylresorcinol (Standard)
0 ImagesCat. No.: HY-N2673RCAS No.: 41442-57-3Synonyms: 5-n-Heptadecylresorcinol (Standard); AR-C17 (Standard)5-Heptadecylresorcinol (AR-C17), a phenolic lipid component, is also an orally active mitochondrial protector. 5-Heptadecylresorcinol improves mitochondrial function via sirtuin3 signaling pathway, thus alleviates endothelial cell damage and apoptosis. 5-Heptadecylresorcinol induces sirtuin3-mediated autophagy. 5-Heptadecylresorcinol reduces the atherosclerotic plaques in the aortic root region of mice heart. 5-Heptadecylresorcinol can be used for research of atherosclerosis prevention and obesity.
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Z-MAL
0 ImagesCat. No.: HY-176545CAS No.: 642463-22-7
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SRT 1720 monohydrochloride (Standard)
0 ImagesSRT 1720 (monohydrochloride) (Standard) is the analytical standard of SRT 1720 (monohydrochloride). This product is intended for research and analytical applications. SRT 1720 monohydrochloride is a selective and orally active activator of SIRT1 with an EC50 of 0.10 μM, and shows less potent activities on SIRT2 and SIRT3.
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Phellopterin (Standard)
0 ImagesPhellopterin (Standard) is the analytical standard of Phellopterin. Phellopterin, an orally active furocoumarin with multiple biological activities. Phellopterin is a partial agonist of the central benzodiazepine receptors. Phellopterin exerts anti-inflammatory effects by upregulating SIRT1, downregulating ICAM-1 (reducing chronic inflammation, aiding diabetic ulcer healing), inhibiting STAT3 phosphorylation (easing atopic dermatitis inflammation), regulating Akt/PKC pathways (lowering TNF-α-induced VCAM-1 to block monocyte adhesion), and inhibiting TLR4/NF-κB pathway and macrophage M2 polarization (alleviating colitis-related cancers). Phellopterin suppresses ovarian cancer progression via inhibiting the PU.1/CLEC5A/PI3K-AKT loop (inducing cell cycle arrest, apoptosis, DNA damage). Phellopterin alleviates murine diabetes by promoting adipocyte differentiation and increasing PPARγ. Phellopterin also has anti-HSV-1 activity. Phellopterin can be used for studying anti-inflammation, anti-cancer (e.g., ovarian cancer, colitis cancer), blood glucose lowering, anti-diabetes, and anti-virus.
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Thiomyristoyl (Standard)
0 ImagesCat. No.: HY-101278RCAS No.: 1429749-41-6Thiomyristoyl (Standard) is the analytical standard of Thiomyristoyl (HY-101278). This product is intended for research and analytical applications. Thiomyristoyl is a potent and specific SIRT2 inhibitor with an IC50 of 28 nM.
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Gamma-glutamylcysteine ammonium
0 ImagesCat. No.: HY-113402BSynonyms: γ-Glu-Cys ammoniumGamma-glutamylcysteine ammonium (γ-Glu-Cys ammonium) is an orally active, blood-brain barrier permeable dipeptide. Gamma-glutamylcysteine ammonium activates AMPK, SIRT1, IL-4/STAT6, AC/cAMP/PI3K, IGF-1R/IRS1/PI3K, and Nrf2 signaling pathways; it inhibits NF-κB, JAK1/STAT1/3, MAPKs, cadmium-induced p38 MAPK, JNK, and PI3K/Akt signaling pathways. Gamma-glutamylcysteine ammonium regulates macrophage polarization, modulates the trafficking of CD36 and GLUT4, induces glutathione synthesis, improves metabolic dysfunction, reduces lipid deposition, ameliorates glucose homeostasis, inhibits apoptosis (Apoptosis), stabilizes mitochondria, suppresses lipid peroxidation, iron accumulation and ferroptosis (Ferroptosis), reduces ds-HMGB1 levels, reverses mechanical hyperalgesia, and alleviates hepatic lipid droplet formation. Gamma-glutamylcysteine ammonium is applicable to research related to inflammatory bowel disease, type 2 diabetes, cadmium-induced neurotoxicity, Alzheimer's disease, cerebral ischemia/reperfusion injury, neuropathy, and alcoholic liver disease.
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CAY10602 (Standard)
0 ImagesCat. No.: HY-104073RCAS No.: 374922-43-7
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SIRT6-IN-2 (Standard)
0 ImagesSIRT6-IN-2 (Standard) is the analytical standard of SIRT6-IN-2 (HY-103721). This product is intended for research and analytical applications. SIRT6-IN-2 (Compound 5) is a selective and competitive SIRT6 inhibitor (IC50: 34 μM). SIRT6-IN-2 increases acetylation of H3K9 and increases glucose uptake in cultured cells. SIRT6-IN-2 also reduces T cell proliferation. SIRT6-IN-2 has immunosuppressive and chemosensitizing effects.
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Cambinol (Standard)
0 ImagesCambinol (Standard) is the analytical standard of Cambinol. This product is intended for research and analytical applications. Cambinol is a SIRT1 and SIRT2 inhibitor with IC50 values of 56 μM and 59 μM, respectively. Cambinol is a potent brain penetrant neutral sphingomyelinase (N-SMase) inhibitor (exosome inhibitor).
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Perindopril-d5
0 ImagesCat. No.: HY-B0130S1Synonyms: S-9490-d5Perindopril-d5 (S-9490-d5) is deuterium labeled Perindopril. Perindopril (S-9490) is an orally available, long-acting angiotensin-converting enzyme (ACE) inhibitor. Perindopril inhibits inflammatory cell influx and intimal thickening, preserving elastin on the inside of the aorta. Perindopril effectively inhibits experimental abdominal aortic aneurysm (AAA) formation in a rat model and reduces pulmonary vasoconstriction in rats with pulmonary hypertension.
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Sirtinol (Standard)
0 ImagesCat. No.: HY-13515RCAS No.: 410536-97-9Sirtinol (Standard) is the analytical standard of Sirtinol. This product is intended for research and analytical applications. Sirtinol is a sirtuin (SIRT) inhibitor, with IC50s of 48 μM, 57.7 μM and 131 μM for ySir2, hSIRT2 and hSIRT2, respectively.
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AK-1 (Standard)
0 ImagesCat. No.: HY-101465RCAS No.: 330461-64-8AK-1 (Standard) is the analytical standard of AK-1 (HY-101465). This product is intended for research and analytical applications. AK-1 is a potent, specific and cell-permeable SIRT2 inhibitor, with an IC50 of 12.5 μM.
