Sirtuin
Sirtuins are a conserved family of NAD+-dependent deacylases and class III histone deacetylases that couple cellular energy status to transcriptional and metabolic regulation, thereby influencing stress adaptation, genome maintenance, and cellular homeostasis[1][2]. Mechanistically, sirtuins respond to fluctuations in NAD+ availability and regulate pathways associated with oxidative stress resistance, mitochondrial function, DNA repair, and metabolic efficiency through deacylation of histone and non-histone protein targets[2][3][4]. These activities place sirtuins at the intersection of nutrient sensing and cellular responses to environmental and physiological perturbations, including fasting, caloric restriction, DNA damage, and redox imbalance[2][4]. In disease-relevant contexts and experimental models, altered sirtuin activity has been linked to aging-related functional decline, metabolic disorders, inflammation, and impaired mitochondrial homeostasis, making the family an important framework for mechanistic studies of age-associated pathophysiology[2][5]. Compared with related isoforms, mammalian SIRT1-SIRT7 display distinct subcellular localization and biological functions, with SIRT1, SIRT6, and SIRT7 enriched mainly in the nucleus, SIRT2 primarily localized in the cytoplasm, and SIRT3, SIRT4, and SIRT5 concentrated in mitochondria, supporting isoform-specific regulation of cellular processes[1][3]. For experimental applications, sirtuin-modulating compounds, including sirtuin-activating compounds and inhibitors such as nicotinamide, are widely used to investigate NAD+-dependent signaling networks and the contribution of individual sirtuin isoforms to metabolism, aging, and disease mechanisms[5][6].
References:
- [1]. Zhao L, et al. Sirtuins and their Biological Relevance in Aging and Age-Related Diseases. Aging Dis. 2020 Jul 23;11(4):927-945. [Content Brief]
- [2]. Imai S, et al. NAD+ and sirtuins in aging and disease. Trends Cell Biol. 2014 Aug;24(8):464-71. [Content Brief]
- [3]. Shahgaldi S, et al. A comprehensive review of Sirtuins: With a major focus on redox homeostasis and metabolism. Life Sci. 2021;282:119803.
- [4]. Imai S, et al. It takes two to tango: NAD+ and sirtuins in aging/longevity control. npj Aging Mech Dis. 2016;2:16017.
- [5]. Bonkowski MS, et al. Slowing ageing by design: the rise of NAD+ and sirtuin-activating compounds. Nat Rev Mol Cell Biol. 2016 Nov;17(11):679-690. [Content Brief]
- [6]. Wikipedia.
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Sirtuin Related Products (151)
Related Products (151)
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SIRT-IN-5
0 ImagesCat. No.: HY-169051CAS No.: 3104122-36-0SIRT-IN-5 is a SIRT3 inhibitor, with an IC50 value of 2.88 μM. SIRT-IN-5 can promote the differentiation of multiple myeloma cells, along with an increase in the expression of the differentiation antigen CD49e and human immunoglobulin light chains λ and κ.
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Phoenixin-14 TFA
0 ImagesCat. No.: HY-P5762ASynonyms: PNX-14 TFAPhoenixin-14 (PNX-14) TFA is an endogenous neuropeptide with multiple biological activities, and serves as the endogenous ligand of GPR173. Phoenixin-14 TFA reduces ROS production by inhibiting the HMGB1/TLR4/MyD88/NF-κB signaling axis, thereby exerting antioxidant and mitochondrial protective effects. Phoenixin-14 TFA inhibits FOXO3 phosphorylation by upregulating SIRT3 expression, suppresses apoptosis, and improves myocardial systolic/diastolic function. Phoenixin-14 TFA resists ferroptosis by activating the ATF4/SLC7A11/GPX4 axis; it activates ERK1/2 phosphorylation via GPR173. Phoenixin-14 TFA can be used in researches on neuroprotection, diabetes, cardiomyopathy, reproductive protection and so on.
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Resveratrol analog 2
0 ImagesCat. No.: HY-136204CAS No.: 915378-82-4Resveratrol analog 2 is an analog of Resveratrol (HY-16561). Resveratrol is a natural polyphenolic phytoalexin that possesses anti-oxidant, anti-inflammatory, cardioprotective, and anti-cancer properties.
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SIRT-IN-4
0 ImagesCat. No.: HY-163698CAS No.: 3052115-51-9SIRT-IN-4 is an inhibitor of the NAD+-dependent lysine deacetylase Sirtuin2 (Sirt2) (IC50=0.35 μM). SIRT-IN-4 is a potent Sirt2 deacetylase inhibitor that reduces cell survival and inhibits the migration of prostate cancer cells. SIRT-IN-4 can be used to study Sirt2 in cell cycle regulation, gene expression regulation, etc.
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ZINC08792355
0 ImagesCat. No.: HY-126904CAS No.: 904513-52-6
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SRT3657
0 ImagesCat. No.: HY-136094CAS No.: 1383551-17-4SRT3657 is a brain-permeable activator of SIRT1, with neuroprotective effect.
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NSC 90469 (Standard)
0 ImagesCat. No.: HY-114557RCAS No.: 1041-01-6Synonyms: 3,5-Diiodo-L-thyronine (Standard)NSC 90469 (Standard) is the analytical standard of NSC 90469. This product is intended for research and analytical applications. NSC 90469 (3,5-Diiodo-L-thyronine) is an orally active thyroid hormone derivative. NSC 90469 inhibits JNK phosphorylation and NF-κB acetylation, blocks SIRT1 protein expression, induces elevated PGC-1α levels, and stimulates COX activity. NSC 90469 enhances UCP1-mediated thermogenesis, increases hepatic Dio1 activity, inhibits TSH levels and hypothalamic-pituitary-thyroid axis function, enhances lipid metabolism, and regulates energy metabolism via the mitochondrial pathway. NSC 90469 prevents blood glucose reduction, reduces urinary albumin excretion, inhibits renal matrix expansion, decreases TGF-β1 expression, and reduces renal fibronectin and type Ⅳ collagen deposition. NSC 90469 also increases energy expenditure and prevents diet-induced overweight. NSC 90469 can be used in studies related to diabetic nephropathy, hypothyroidism, non-alcoholic fatty liver disease, and diet-induced obesity.
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SRTCX1002
0 ImagesCat. No.: HY-114981CAS No.: 1203479-63-3SRTCX1002 is a potent activator of SIRT1 (STAC), suppresses inflammatory responses through promotion of p65 deacetylation and inhibition of NF-κB Activity. SRTCX1002 suppresses stimuli-induced NF-κB transcriptional activation and LPS-induced TNFα secretion with IC50s of 0.71 and 7.58 µM, respectively.
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Ciliatoside A
0 ImagesCat. No.: HY-N21694CAS No.: 303084-57-3Ciliatoside A is a naturally bioactive compound that exhibits significant anti-inflammatory, antiviral, and neuroprotective activities. Ciliatoside A serves as a mitophagy inducer and NLRP3 inflammasome inhibitor, activating AMPK, SIRT1, and the PINK1/Parkin axis, and inhibiting pyroptosis and apoptosis. Ciliatoside A promotes autophagic flux, autophagosome-lysosome fusion, mTOR inhibition, and p62-dependent HBc degradation; reduces Aβ aggregation, plaque deposition, microglial/astrocyte activation, and bacterial load; and maintains neuronal integrity, mitochondrial membrane potential, and ATP production. Ciliatoside A is used in research on Alzheimer's disease, Klebsiella pneumoniae-induced pneumonia, hepatitis B virus infection, and inflammation.
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SRTCX1003
0 ImagesCat. No.: HY-124240CAS No.: 1203480-86-7SRTCX1003 is an orally active SIRT1 activator. SRTCX1003 suppresses inflammatory responses.
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4-Hydroxyestrone-13C6
0 ImagesCat. No.: HY-W009300S1Synonyms: 4-OHE1-13C64-Hydroxyestrone (4-OHE1)-13C6 is a 13C-labeled 4-Hydroxyestrone (HY-W009300). 4-Hydroxyestrone is a brain-penetrant estrogen metabolite. 4-Hydroxyestrone shows neuroprotective effects involving increased cytoplasmic localization of p53 resulting from SIRT1-mediated p53 deacetylation. 4-Hydroxyestrone relies on PDI to mediate its protective effect against chemically induced ferroptosis in estrogen receptor-negative cancer cells. 4-Hydroxyestrone inhibits lipid peroxidation and lipid-ROS accumulation. 4-Hydroxyestrone blocks preovulatory luteinizing hormone surges in Rattus norvegicus. 4-Hydroxyestrone can be used for the researches of neurodegeneration, breast cancer and endocrine disease.
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Ac-QPKK(Ac)-AMC
0 ImagesCat. No.: HY-P3364CAS No.: 1387005-23-3Ac-QPKK(Ac)-AMC is a p53-derived peptide conjugated with a fluorophore, which serves as a fluorescent peptide substrate for detecting the deacylase activity of zinc-dependent HDACs and sirtuins (Ex = 360 nm; Em = 460 nm).
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Aristoforin
0 ImagesCat. No.: HY-133849CAS No.: 849215-53-8Aristoforin, a hypericin derivative, inhibits the activities of SIRT1 and SIRT2. Aristoforin induces G1 phase cell cycle arrest, scavenges hydroxyl free radicals, and exhibits protective activity against Fe2+-induced DNA breakage. Aristoforin can be used in studies related to breast cancer and colon adenocarcinoma.
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Ganoderic acid D (Standard)
0 ImagesCat. No.: HY-N1511RCAS No.: 108340-60-9Ganoderic acid D (Standard) is the analytical standard of Ganoderic acid D. This product is intended for research and analytical applications. Ganoderic acid D, a highly oxygenated tetracyclic triterpenoid, is the major active component of Ganoderma lucidum. Ganoderic acid D upregulates the protein expression of SIRT3 and induces the deacetylated cyclophilin D (CypD) by SIRT3. Ganoderic acid D inhibits the energy reprogramming of colon cancer cells including glucose uptake, lactate production, pyruvate and acetyl-coenzyme production in colon cancer cells. Ganoderic acid D induces HeLa human cervical carcinoma apoptosis.
