SIRT2-IN-10
SIRT2-IN-10 (Compound 12) is a potent SIRT2 inhibitor with an IC50 of 1.3 μM. SIRT2-IN-10 can be used for the research of cancer and neurodegenerative disease.
For research use only. We do not sell to patients.
- CAS No.: 296793-09-4
- Formula: C28H21N5OS
- Molecular Weight:475.56
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
SIRT2[1]
SIRT2-IN-10 (Compound 12) (0-50 μM; 72 h) inhibits the proliferation of MCF-7 cells in a concentration-dependent manner[1].
SIRT2-IN-10 (6.25-50 μM; 6 h) increased the acetylation level of α-tubulin in a concentration-dependent manner in MCF-7 cells[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:MCF-7 cells
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Concentration:0, 0.6, 1.8, 5.5, 16.6 and 50.0 μM
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Incubation Time:72 h
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Result:Inhibited the proliferation in a concentration-dependent manner.
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Cell Line:MCF-7 cells
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Concentration:6.25, 12.5, 25 and 50 μM
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Incubation Time:6 h
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Result:Dose-dependently increased the acetylation level of α-tubulin.
Chemical Information
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CAS No. 296793-09-4
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Molecular Weight 475.56
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Formula C28H21N5OS
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SMILES
O=C(CSC1=NC2=C(C(C=CC=C3)=C3N2CC4=CC=CC=C4)N=N1)NC5=C(C=CC=C6)C6=CC=C5
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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