SIRT2-IN-10

Cat. No.: HY-151522: FAQs
Data Sheet Handling Instructions

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SIRT2-IN-10 (Compound 12) is a potent SIRT2 inhibitor with an IC₅₀ of 1.3 μM. SIRT2-IN-10 can be used for the research of cancer and neurodegenerative disease.

For research use only. We do not sell to patients.

SIRT2-IN-10 Chemical Structure

CAS No. : 296793-09-4

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Biological Activity
Purity & Documentation
References
Customer Review

Description

SIRT2-IN-10 (Compound 12) is a potent SIRT2 inhibitor with an IC₅₀ of 1.3 μM. SIRT2-IN-10 can be used for the research of cancer and neurodegenerative disease^[1].

IC₅₀ & Target

SIRT2^[1]

In Vitro

SIRT2-IN-10 (Compound 12) (0-50 μM; 72 h) inhibits the proliferation of MCF-7 cells in a concentration-dependent manner^[1].
SIRT2-IN-10 (6.25-50 μM; 6 h) increased the acetylation level of α-tubulin in a concentration-dependent manner in MCF-7 cells^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Proliferation Assay^[1]

Cell Line:	MCF-7 cells
Concentration:	0, 0.6, 1.8, 5.5, 16.6 and 50.0 μM
Incubation Time:	72 h
Result:	Inhibited the proliferation in a concentration-dependent manner.

Western Blot Analysis^[1]

Cell Line:	MCF-7 cells
Concentration:	6.25, 12.5, 25 and 50 μM
Incubation Time:	6 h
Result:	Dose-dependently increased the acetylation level of α-tubulin.

Molecular Weight

475.56

Formula

C₂₈H₂₁N₅OS

CAS No.

296793-09-4

SMILES

O=C(CSC1=NC2=C(C(C=CC=C3)=C3N2CC4=CC=CC=C4)N=N1)NC5=C(C=CC=C6)C6=CC=C5

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Shengyong Yang, et al. The purposes of 5H- [1,2,4] triazine [5,6-b] indole derivatives of 3 substitutions. Patent CN108309982A.

SIRT2-IN-10 Related Classifications

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

The dilution calculator equation

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

SIRT2-IN-10296793-09-4Sirtuincancerneurodegenerative diseaseMCF-7Inhibitorinhibitorinhibit

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