Thyroid Hormone Receptor
THR
Thyroid hormone receptor is a member of the nuclear receptor superfamily that shuttles between the cytosol and nucleus. Thyroid hormone receptors are ligand-dependent transcription factors that mediate the biological activities of thyroid hormone (T3). Thyroid hormone receptors are encoded by two genes, one for TRα and another for TRβ, which encode the major isoforms of TR, including TRα1, TRα2, TRβ1, and TRβ2. The thyroid hormone receptors mediate the pleiotropic activities of the thyroid hormone (T3) in growth, development, and differentiation and in maintaining metabolic homeostasis.
Thyroid hormone receptors are zinc finger transcription factors in the erbA superfamily that bind DNA at specific response element sequences (thyroid hormone response elements, TREs) and activate gene expression in response to thyroid hormone (T3). Thyroid hormone receptors have been shown to bind DNA as monomers, homodimers, or heterodimers with another erbA superfamily member, the retinoid X receptor (RXR).
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Thyroid Hormone Receptor Inhibitors
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Thyroid Hormone Receptor Agonists
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Thyroid Hormone Receptor Antagonists
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Thyroid Hormone Receptor Activators
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Thyroid Hormone Receptor Modulators
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Thyroid Hormone Receptor Controls
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Thyroid Hormone Receptor Ligand
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Thyroid Hormone Receptor Related Products (187)
Related Products (187)
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Antibodies (5)
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Debutyldronedarone-d7 hydrochloride
0 ImagesCat. No.: HY-12753ASSynonyms: SR35021-d7 hydrochlorideDebutyldronedarone-d7 hydrochloride (SR35021-d7 hydrochloride) is the deuterated-labeled Debutyldronedarone (hydrochloride) (HY-12753A). Debutyldronedarone hydrochloride (SR35021 hydrochloride) is a Cytochrome P450 enzyme inhibitor and a Thyroid Hormone Receptor inhibitor, and it is a metabolite of Dronedarone (HY-A0016). Debutyldronedarone hydrochloride inhibits the binding of T3 to TRα1 and TRβ1. Debutyldronedarone hydrochloride reduces the incidence of reperfusion-induced ventricular fibrillation in anesthetized rats, while decreasing their heart rate and blood pressure. Debutyldronedarone hydrochloride can be used in studies related to ventricular fibrillation and atrial fibrillation.
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TR modulator-1
0 ImagesCat. No.: HY-186138CAS No.: 1073180-47-8TR modulator-1 (compound 10c) is a selective thyroid hormone receptor (TR) modulator. TR modulator-1 can be used in the research of hyperthyroidism and thyrotoxicosis.
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THR-β modulator-3
0 ImagesCat. No.: HY-180642CAS No.: 3052978-35-2THR-β modulator-3 (Compound 75-2) is a THR-β modulator. THR-β modulator-3reduces total fat mass, body weight. THR-β modulator-3 improves obesity.
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Debutyldronedarone
0 ImagesCat. No.: HY-12753CAS No.: 141626-35-9Synonyms: SR35021Debutyldronedarone (SR35021) is a Cytochrome P450 enzyme inhibitor and a Thyroid Hormone Receptor inhibitor, and it is a metabolite of Dronedarone (HY-A0016). Debutyldronedarone inhibits the binding of T3 to TRα1 and TRβ1. Debutyldronedarone reduces the incidence of reperfusion-induced ventricular fibrillation in anesthetized rats, while decreasing their heart rate and blood pressure. Debutyldronedarone can be used in studies related to ventricular fibrillation and atrial fibrillation.
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Parathyroid Hormone (1-34), bovine TFA
0 ImagesCat. No.: HY-P1252AParathyroid Hormone (1-34), bovine TFA is a potent parathyroid hormone (PTH) receptor agonist. Parathyroid Hormone (1-34), bovine increases calcium and inorganic phosphate levels in vivo. Parathyroid Hormone (1-34), bovine can be used for th reseach of osteoporosis.
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THR-β agonist 6
0 ImagesCat. No.: HY-149218CAS No.: 2791290-58-7THR-β agonist 6 is an orally active, selective thyroid hormone receptor β (THR-β) agonist with EC50s of 0.03 μM and 0.22 μM for THR-β and THR-α, respectively. THR-β agonist 6 exhibits an xcellent liver-to-serum ratio of 93:1 in mice. THR-β agonist 6 has the potential for nonalcoholic steatohepatitis (NASH) research.
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pTH (13-34) (human)
0 ImagesCat. No.: HY-P4690CAS No.: 81306-64-1pTH (13-34) (human) is apTH ((Human parathyroid hormone) fragment.
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Teriparatide acetate hydrate
0 ImagesCat. No.: HY-P0059ACAS No.: 99294-94-7Synonyms: Human parathyroid hormone-(1-34) acetate hydrate; hPTH (1-34) acetate hydrateTeriparatide acetate hydrate (Human parathyroid hormone-(1-34) acetate hydrate) is a PTH1 receptor agonist. Teriparatide acetate hydrate (Human parathyroid hormone-(1-34) acetate hydrate) can be used for osteoporosis research.
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THR-β agonist 11
0 ImagesCat. No.: HY-178015CAS No.: 3051970-23-8THR-β agonist 11 is an orally active and selective thyroid hormone receptor (THR-β) agonist. THR-β agonist 11 shows potent cholesterol-lowering activity in cholesterol-fed rats. THR-β agonist 11 significantly reduces serum total TG, LDL-cholesterol, liver total TC and TG levels, and alleviates hepatic steatosis, inflammation and fibrosis in HFD-CCl4-induced Metabolic dysfunction-associated steatohepatitis (MASH) model mice. THR-β agonist 11 can be used for the study of metabolic dysfunction-associated steatohepatitis (MASH) and other fibrotic diseases.
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Macotirom
0 ImagesCat. No.: HY-187798CAS No.: 2673409-79-3Macotirom is a thyroid hormone β receptor agonist. Macotirom can be used in studies related to metabolic diseases and the liver.
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Human PTH-(1-31) amide
0 ImagesCat. No.: HY-P4818CAS No.: 173833-08-4Human PTH-(1-31) amide is a PTH analog. Human PTH-(1-31) amide stimulate phosphatidylcholine hydrolysis and stimulates adenylyl cyclase release.
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3,5-Diiodothyroacetic acid
0 Images3,5-Diiodothyroacetic acid is a thyroid hormone analog. 3,5-Diiodothyroacetic acid lowers blood cholesterol concentrations. 3,5-Diiodothyroacetic acid can be used for hypothyroidism diseases research.
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THR-β agonist 8
0 ImagesCat. No.: HY-171013CAS No.: 2832859-77-3THR-β agonist 8 (Compound 1) is an orally active agonist of TRα and TRβ. THR-β agonist 8 is promising for research of thyroid hormone-related diseases.
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Prepro-TRH-(160-169)
0 ImagesCat. No.: HY-P3969CAS No.: 122018-91-1Prepro-TRH-(160-169) is one of the connecting peptides of thyrotropin-releasing hormone prohormone (pro-TRH), potentiates TRH-induced thyrotropin (TSH) release.
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Montirelin
0 ImagesCat. No.: HY-19154CAS No.: 90243-66-6Synonyms: NS 3Montirelin (NS 3) is an analog of thyrotropin-releasing hormone (TRH), and exhibits high affinity to TRH receptors. Montirelin exhibits potent effects to central nervous system (CNS).
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pTH-Related Protein (7-34) amide (human, mouse, rat)
0 ImagesCat. No.: HY-P4857CAS No.: 115695-30-2pTH-Related Protein (7-34) amide (human, mouse, rat) is a potent antagonist of parathyroid hormone (PTH).
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Etiroxate
0 ImagesCat. No.: HY-111983CAS No.: 17365-01-4Synonyms: CG-635Etiroxate (CG-635) is a lipid lowing compound which can be used for hyperlipoproteinemia research.
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THR-β agonist 2 diacetate
0 ImagesCat. No.: HY-143613ATHR-β agonist 2 (Compound 3) diacetate is a selective thyroid hormone receptor β (THRβ) agonist with an EC50 of 1.42 μM. THR-β agonist 2 diacetate can regulate the biological pathways mediated by thyroid hormones. THR-β agonist 2 diacetate can be used for the study of metabolic diseases.
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ITYR-DBRMD
0 ImagesCat. No.: HY-182688CAS No.: 1809339-61-4ITYR-DBRMD is a type III deiodinase (DIO3) inhibitor. ITYR-DBRMD shows antidepressant-like activity and reduces latency to feed in mice. ITYR-DBRMD can be used for the research of depression.
