Thyroid Hormone Receptor
THR
Thyroid hormone receptor is a member of the nuclear receptor superfamily that shuttles between the cytosol and nucleus. Thyroid hormone receptors are ligand-dependent transcription factors that mediate the biological activities of thyroid hormone (T3). Thyroid hormone receptors are encoded by two genes, one for TRα and another for TRβ, which encode the major isoforms of TR, including TRα1, TRα2, TRβ1, and TRβ2. The thyroid hormone receptors mediate the pleiotropic activities of the thyroid hormone (T3) in growth, development, and differentiation and in maintaining metabolic homeostasis.
Thyroid hormone receptors are zinc finger transcription factors in the erbA superfamily that bind DNA at specific response element sequences (thyroid hormone response elements, TREs) and activate gene expression in response to thyroid hormone (T3). Thyroid hormone receptors have been shown to bind DNA as monomers, homodimers, or heterodimers with another erbA superfamily member, the retinoid X receptor (RXR).
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Thyroid Hormone Receptor Inhibitors
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Thyroid Hormone Receptor Agonists
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Thyroid Hormone Receptor Antagonists
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Thyroid Hormone Receptor Activators
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Thyroid Hormone Receptor Modulators
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Thyroid Hormone Receptor Controls
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Thyroid Hormone Receptor Ligand
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Thyroid Hormone Receptor Related Products (187)
Related Products (187)
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Antibodies (5)
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THR-β agonist 5
0 ImagesTHR-β agonist 5 is a THR-β agonist. THR-β agonist 5 can be used for the research of nonalcoholic fatty liver disease, nonalcoholic steatohepatitis.
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Parathyroid Hormone (1-34), human, biotinylated
0 ImagesCat. No.: HY-P2510Purity: 99.49%Parathyroid Hormone (1-34), human, biotinylated is a probe for the parathyroid hormone receptor, can be used for analyzing the interaction between parathyroid hormone and parathyroid hormone receptors in living cells and for purifying hormone-receptor complexes with affinity columns.
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Debutyldronedarone-d6 hydrochloride
0 ImagesSynonyms: SR35021-dd6 hydrochlorideDebutyldronedarone-d6 hydrochloride (SR35021-d6 hydrochloride) is the deuterated-labeled Debutyldronedarone (HY-12753). Debutyldronedarone (SR35021) is a Cytochrome P450 enzyme inhibitor and a Thyroid Hormone Receptor inhibitor, and it is a metabolite of Dronedarone (HY-A0016). Debutyldronedarone inhibits the binding of T3 to TRα1 and TRβ1. Debutyldronedarone reduces the incidence of reperfusion-induced ventricular fibrillation in anesthetized rats, while decreasing their heart rate and blood pressure. Debutyldronedarone can be used in studies related to ventricular fibrillation and atrial fibrillation.
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Calcitonin, eel
0 ImagesCat. No.: HY-P1463CAS No.: 57014-02-5Synonyms: Thyrocalcitonin eelCalcitonin, eel is the thyroid hormone peptide that contributes to the regulation of calcium homeostasis, widely used in the research of postmenopausal osteoporosis.
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Glutaurine TFA
0 ImagesCat. No.: HY-106608ASynonyms: Litoralon TFAGlutaurine (Litoralon) TFA containing glutamine and taurine residues is an orally active hormone of the parathyroid. Glutaurine (Litoralon) TFA, as a hormone, is isolated from parathyroid gland oxyphil cells. Glutaurine (Litoralon) TFA can be used for the research of antiepileptic and anti-amnesia.
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TRβ agonist 1
0 ImagesCat. No.: HY-146997CAS No.: 2770681-85-9TRβ agonist 1 is a selective and mutation-sensitive thyroid hormone receptor β (TRβ) agonist, with an EC50 value of 21 nM. TRβ agonist 1 can be used for researching dyslipidemia, nonalcoholic steatohepatitis (NASH), and resistance to thyroid hormone (RTH).
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1α-Hydroxy-3-epi-vitamin D3 (Standard)
0 ImagesCat. No.: HY-10003ARCAS No.: 58028-00-51α-Hydroxy-3-epi-vitamin D3 (Standard) is the analytical standard of 1α-Hydroxy-3-epi-vitamin D3 (HY-10003A). This product is intended for research and analytical applications. 1α-Hydroxy-3-epi-vitamin D3, a natural metabolite of 1alpha,25-dihydroxyvitamin D3, is a potent suppressor of parathyroid hormone (PTH) secretion.
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THR-β agonist 3
0 ImagesCat. No.: HY-143614CAS No.: 2656400-84-7THR-β agonist 3 is a potent agonist of THR-β. THR-β agonist 3 has the potential for the research of metabolic diseases such as obesity, hyperlipidemia, hypercholesterolemia, diabetes and other conditions such as steatosis and non-alcoholic steatohepatitis (NASH), atherosclerosis and other related conditions and diseases (extracted from patent WO2021129827A1, compound 6).
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pTH (1-44) (human)
0 ImagesCat. No.: HY-P4692CAS No.: 85568-24-7pTH (1-44) (human) is apTH ((Human parathyroid hormone) fragment.
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MK771
0 ImagesCat. No.: HY-119174CAS No.: 66537-55-1MK771 is a thyrotrophin-releasing hormone analog. MK771 induces blinking and forepaw licking. MK771 has the potential for the research of morphine abstinence syndrome.
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THR-β agonist 9
0 ImagesCat. No.: HY-174887CAS No.: 2920045-74-3THR-β agonist 9 is a potent, selective, and His435 mutation-sensitive THR-β (EC50: 3.2 nM) agonist. THR-β agonist 9 has moderate selectivity (approximately 10-fold) and good activation capacity (EC50: 134.2 nM to 515.5 nM) for multiple His435 mutants (H435A, H435Y, and H435R). THR-β agonist 9 has the potential to be used in the study of dyslipidemia, metabolic dysfunction-associated steatohepatitis (MASH), or resistance to thyroid hormone (RTH).
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TR modulator-1 bromide
0 ImagesCat. No.: HY-186138ATR modulator-1 (compound 10c) bromide is a selective thyroid hormone receptor (TR) modulator. TR modulator-1 bromide can be used in the research of hyperthyroidism and thyrotoxicosis.
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Fenclofenac (Standard)
0 ImagesCat. No.: HY-114806RCAS No.: 34645-84-6Synonyms: Flenac (Standard); R 67408 (Standard)Fenclofenac (Standard) is the analytical standard of Fenclofenac. This product is intended for research and analytical applications. Fenclofenac is an orally active anti-inflammatory agent with a low ulcerogenic effect. Fenclofenac also exhibits antipyretic and analgesic activities, with an oral LD50 of 2280 mg/kg in rats. Fenclofenac can be utilized in inflammation research.
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Simedeutirom
0 ImagesCat. No.: HY-172439SCAS No.: 2403721-24-2Simedeutirom is the agonist for thyroid hormone beta receptor (THRβ) and can be used for researchs of metabolic diseases, such as obesity and diabetes mellitus.
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Axitirome
0 ImagesCat. No.: HY-19201CAS No.: 156740-57-7Synonyms: CGS 26214Axitirome (CGS 26214) is a potent, liverselective TRβ receptor agonist and thyromimetic agent. Axitirome has demonstrated cholesterol-lowering activity.
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TRβ agonist 3
0 ImagesCat. No.: HY-147501CAS No.: 2411099-46-0TRβ agonist 3 (Compound 3) is a potent agonist of TRβ. TRβ agonist 3 reduces lipid accumulation in HepG2 and promote lipolysis with comparable effects. TRβ agonist 3 is a new potential TRβ-selective thyromimetics.
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DPC-AJ1951
0 ImagesCat. No.: HY-P1418CAS No.: 943519-33-3DPC-AJ1951, a 14 amino acid peptide that acts as a potent agonist of the parathyroid hormone (PTH)/PTH-related peptide receptor (PPR). And characterized the activity of DPC-AJ1951 in ex vivo and in vivo assays of bone resorption.
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GC 14
0 ImagesCat. No.: HY-111442CAS No.: 447415-34-1GC 14 is a selective thyroid hormone receptor antagonist, with IC50 values of 35 nM and 200 nM for hTRβ and hTRα, respectively.
