Topoisomerase
Topoisomerases are enzymes that regulate the overwinding or underwinding of DNA. The winding problem of DNA arises due to the intertwined nature of its double-helical structure. Topoisomerases are isomerase enzymes that act on the topology of DNA. Type I topoisomerase cuts one strand of a DNA double helix, relaxation occurs, and then the cut strand is reannealed. Type I topoisomerases are subdivided into two subclasses: type IA topoisomerases, which share many structural and mechanistic features with the type II topoisomerases, and type IB topoisomerases, which utilize a controlled rotary mechanism. Type II topoisomerase cuts both strands of one DNA double helix, pass another unbroken DNA helix through it, and then reanneal the cut strands. This class is also split into two subclasses: type IIA and type IIB topoisomerases, which possess similar structure and mechanisms.
Topoisomerase Isoform Specific Products
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Topoisomerase Inhibitors
(754)
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Topoisomerase Agonists
(2)
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Topoisomerase Modulator
(1)
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Topoisomerase Inducer
(1)
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Topoisomerase Degraders
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Topoisomerase Controls
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Topoisomerase Ligands
(2)
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Topoisomerase Proteins
(1)
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DNA topoisomerase II Proteins
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Topoisomerase Related Products (831)
Related Products (831)
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Recombinant Proteins (1)
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Antibodies (4)
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Topoisomerase Isoform Comparison
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N-(endo-BCN-PEG4)-N-(PEG4-Val-Cit-PAB-MMAE)-N-(PEG4-Val-Cit-PAB-Exatecan)
0 ImagesCat. No.: HY-177684N-(endo-BCN-PEG4)-N-(PEG4-Val-Cit-PAB-MMAE)-N-(PEG4-Val-Cit-PAB-Exatecan) is a drug-linker conjugate for ADC (Drug-Linker Conjugate for ADC), consisting of a tubulin polymerization inhibitor MMAE (HY-15162) and a DNA topoisomerase I inhibitor Exatecan (HY-13631), and an ADC linker composition. N-(endo-BCN-PEG4)-N-(PEG4-Val-Cit-PAB-MMAE)-N-(PEG4-Val-Cit-PAB-Exatecan) can be used for synthesis of ADCs and for cancer research.
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SN-28049
0 ImagesSN-28049 is a new DNA-binding topoisomerase II-directed antitumor agent. SN-28049 activates the p53 pathway. SN-28049 exhibits anticancer activity against colorectal cancer.
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Glycyl-Exatecan
0 ImagesCat. No.: HY-128995CAS No.: 849479-60-3Synonyms: Glycyl-DX-8951; Exatecan analog 2Glycyl-Exatecan (G-DX-8951) is a Topoisomerase I inhibitor. Glycyl-Exatecan exhibits weaker in vitro cytotoxicity than DX-8951 (HY-13631), and can further release DX-8951 in vivo. Glycyl-Exatecan can be used in studies related to Exatecan metabolism and antitumor drug delivery.
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Maleimide-Ph(3,5-F)-PEG4-Val-Ala-MF-6
0 ImagesCat. No.: HY-175216Maleimide-Ph(3,5-F)-PEG4-Val-Ala-MF-6 is a drug-linker conjugate for ADC. Maleimide-Ph(3,5-F)-PEG4-Val-Ala-MF-6 consists of a topoisomerase 1 inhibitor (Topi MF-6) (HY-175203) and a cleavable linker (Maleimide-Ph(3,5-F)-PEG4-Val-Ala) (HY-175218). Maleimide-Ph(3,5-F)-PEG4-Val-Ala-MF-6 can be used for synthesis of ADCs.
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Gly-Cyclopropane-Exatecan
0 ImagesCat. No.: HY-148696ACAS No.: 2414254-49-0Gly-Cyclopropane-Exatecan involves in the synthesis of anti-B7-H4 ADC, containing Exatecan (HY-13631), a DNA Topoisomerase I inhibitor. Gly-Cyclopropane-Exatecan participated in the formation of the ADC hu2F7-Exatecan (compound 34), which showed antitumor activity in vivo and in vitro.
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PD 124816
0 ImagesCat. No.: HY-W780694CAS No.: 112654-98-5PD 124816 is an orally active fluoroquinolone antibiotic. PD 124816 exerts broad-spectrum antibacterial effects by inhibiting DNA gyrase (topoisomerase IV), and it has no cross-resistance with commonly used antibiotics. PD 124816 is effective against both Gram-positive and Gram-negative bacteria (MIC₉₀ ≤ 0.06 μg/mL), and the MIC₉₀ for anaerobic bacteria (Peptostreptococcus fragi) is 1 μg/mL. PD 124816 exhibits complete bactericidal activity in a mouse model of Mycobacterium leprae infection. PD 124816 can be used for studying mixed infections and infections caused by drug-resistant bacteria.
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S 39625
0 ImagesCat. No.: HY-122014CAS No.: 536711-20-339625 is a camptothecin ketone analogue, a stable, potent and selective topoisomerase I inhibitor, active against purified topoisomerase I and cytotoxic to cancer cells.
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XSJ110
0 ImagesCat. No.: HY-174151CAS No.: 203923-65-3XSJ110 is a potent irreversible topoisomerase I (Topo I) inhibitor with an IC50 value of 0.133 μM. XSJ110 blocks DNA topoisomerization, induces DNA double-strand breaks, and triggers cell cycle arrest at G0/G1 phase, inducing tumor cell apoptosis. XSJ110 is promising for research of ampullary carcinoma (AC).
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Ro 47-3359
0 ImagesCat. No.: HY-120173CAS No.: 155144-64-2Ro 47-3359 is a pyrimido[1,6-a]benzimidazole compound with the activity of enhancing eukaryotic topoisomerase II-mediated DNA cleavage and being toxic to Kc cells.
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Topoisomerase II inhibitor 15
0 ImagesCat. No.: HY-155645CAS No.: 451516-79-3Topoisomerase II inhibitor 15 (compound 2g) is a Topoisomerase II inhibitor. Topoisomerase II inhibitor 15 potently is an apoptotic inducer with greater selectivity against head and neck tumors.
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(R)-(4-NH2)-Exatecan
0 ImagesCat. No.: HY-145397ACAS No.: 3123392-57-1Synonyms: (R)-AZ14170132(R)-(4-NH2)-Exatecan is the R enantiomer of (4-NH2)-Exatecan (Compound A). (R)-(4-NH2)-Exatecan, a topoisomerase inhibitor, is a derivative of Exatecan. (R)-(4-NH2)-Exatecan can be used in the synthesis of antibody-drug conjugates (ADCs).
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CP 80080
0 ImagesCat. No.: HY-124336CAS No.: 152247-02-4CP 80080 is a Topoisomerase II ligand with almost no ability to stimulate topoisomerase II-mediated DNA cleavage. CP 80080 competes with DNA cleavage-enhancing antineoplastic agents for a common binding domain on Drosophila topoisomerase II, thereby attenuating the ability of these agents to stimulate topoisomerase II-mediated DNA cleavage. CP 80080 can be used in cancer-related research.
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MC-Val-Cit-Gly-exatecan-β-D-glucopyranosiduronic acid
0 ImagesCat. No.: HY-164380CAS No.: 3023709-42-1MC-Val-Cit-Gly-exatecan-β-D-glucopyranosiduronic acid (example 13) is a drug-linker conjugate that consists of a DNA topoisomerase I inhibitor Exatecan (HY-13631) and a linker (HY-180841). MC-Val-Cit-Gly-exatecan-β-D-glucopyranosiduronic acid can be used in synthesis of ADC.
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Anticancer agent 337
0 ImagesCat. No.: HY-184750Anticancer agent 337 (compound 5n) is a topoisomerase I inhibitor. Anticancer agent 337 inhibits topoisomerase I activity in a concentration-dependent manner, suppresses cancer cell migration, induces apoptosis, and arrests the cell cycle at the G1 phase. Anticancer agent 337 can be used in the research of lung cancer, hepatocellular carcinoma, and cervical adenocarcinoma.
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9-Chloromethyl-10-hydroxy-11-F-Camptothecin
0 ImagesCat. No.: HY-156723CAS No.: 2414594-22-09-Chloromethyl-10-hydroxy-11-F-Camptothecin is a novel camptothecin derivatives. 9-Chloromethyl-10-hydroxy-11-F-Camptothecin is a DNA topoisomerase I (Topo I) inhibitor, can be used in anticancer research.
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Premafloxacin
0 ImagesCat. No.: HY-180414CAS No.: 143383-65-7Premafloxacin is a potent antimicrobial agent that exhibits activity against Staphylococcus aureus, Corynebacterium bovis, and Corynebacterium amylocolatum. Premafloxacin demonstrated potent antimicrobial activity against S. aureus by targeting topoisomerase IV, and is a poor substrate for NorA efflux pump. Premafloxacin can be used for antimicrobial research.
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Anticancer agent 75
0 ImagesCat. No.: HY-147971CAS No.: 2414491-13-5Anticancer agent 75 is a potent anticancer agent. Anticancer agent 75 shows cytotoxicity and selectivity in cancer cell lines. Anticancer agent 75 shows cytotoxicity to normal human kidney cell lines is at least 35 times lower than that of the Doxorubicin standard. Anticancer agent 75 shows good activity of antiplasmodial.
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Nectandrin B
0 ImagesCat. No.: HY-W713570CAS No.: 74683-16-2Nectandrin B is an inhibitor of DNA topoisomerases I and II, which is found in Saururus chinensis. Nectandrin B is promising for research of cancers.
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Zorubicin
0 ImagesCat. No.: HY-106556CAS No.: 54083-22-6Synonyms: Rubidazon; RubidazoneZorubicin (Rubidazon) is a derivative of Daunorubicin (HY-13062A). Zorubicin interacts with topoisomerase II and inhibits DNA polymerases. Zorubicin can be used for the research of acute leukemias and sarcomas.
