Tetracycline
Tetracycline is a ribosome-targeting antibiotic that inhibits bacterial growth by interfering with protein synthesis, making translation control its core biological function[1]. Mechanistically, tetracyclines interact with the ribosome and inhibit translation, while structural studies show that resistance proteins protect the 70S ribosome from tetracycline binding[2][3]. In bacterial disease and resistance models, tetracycline resistance occurs mainly through energy-dependent efflux, ribosomal protection, target mutation, drug modification, or rare enzymatic inactivation[1][4][5]. Compared with related tetracycline-family compounds, including doxycycline, minocycline, and tigecycline, tetracycline shares ribosomal binding and translation inhibition, but resistance determinants can differ in host range and genetic mobility[1][4][5]. Tet(O) and Tet(M) are key ribosomal protection proteins, and Tet(O) resembles elongation factor EF-G while using domain-specific ribosome contacts to mediate resistance[3][6]. For experimental applications, tetracycline remains useful for studying antibiotic uptake, ribosomal inhibition, efflux pumps, mobile resistance genes, and environmental selection of resistant bacteria[4][5].
References:
- [1]. Nguyen F, et al. Tetracycline antibiotics and resistance mechanisms. Biol Chem. 2014 May;395(5):559-75. [Content Brief]
- [2]. Spahn CM, et al. Localization of the ribosomal protection protein Tet(O) on the ribosome and the mechanism of tetracycline resistance. Mol Cell. 2001 May;7(5):1037-45. [Content Brief]
- [3]. Li W, et al. Mechanism of tetracycline resistance by ribosomal protection protein Tet(O). Nat Commun. 2013;4:1477. [Content Brief]
- [4]. Taylor DE, et al. Tetracycline resistance mediated by ribosomal protection. Antimicrob Agents Chemother. 1996 Jan;40(1):1-5. [Content Brief]
- [5]. Roberts MC. Tetracycline resistance determinants: mechanisms of action, et al. Tetracycline resistance determinants: mechanisms of action, regulation of expression, genetic mobility, and distribution. FEMS Microbiol Rev. 1996 Oct;19(1):1-24. [Content Brief]
- [6]. Connell SR, et al. Ribosomal protection proteins and their mechanism of tetracycline resistance. Antimicrob Agents Chemother. 2003 Dec;47(12):3675-81. [Content Brief]
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Tetracycline Related Products (42)
Related Products (42)
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Meclocycline Sulfosalicylate Salt
0 ImagesMeclocycline Sulfosalicylate Salt is a tetracycline antibiotic with broad-spectrum antibacterial activities, preventing skin bacterial infections such as acne vulgaris.
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Sarecycline hydrochloride
0 ImagesSynonyms: P-005672 hydrochlorideSarecycline hydrochloride is an orally active narrow-spectrum tetracycline derivative antibiotic. Sarecycline hydrochloride has anti-inflammatory activity. Sarecycline hydrochloride inhibits the activity of Gram-positive bacteria and several types of keratobacterium acnes. Sarecycline hydrochloride interferes with tRNA accommodation and tethers mRNA to the 70S ribosome. Sarecycline hydrochloride can be used to study moderate to severe acne .
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Sancycline
0 ImagesSynonyms: Bonomycin; 6-Demethyl-6-deoxytetracyclineSancycline (6-Demethyl-6-deoxytetracycline) acts by reversibly binding to the 30 S ribosomal subunit and inhibiting protein translation by blocking entry of aminoacyl-tRNA into the ribosome a site similar to tetracycline (HY-A0107). Sancycline, four linearly fused six-membered rings with four stereocenters, is a rare semi-synthetic tetracycline (HY-A0107) prepared by hydrogenolysis of the chloro and benzylic hydroxy moieties of Declomycin.
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4-Epitetracycline hydrochloride
0 Images4-Epitetracycline hydrochloride is a reversible epimer of Tetracycline (HY-A0107) that can be interconverted in nature. 4-Epitetracycline hydrochloride exhibits antibacterial activity.
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Meclocycline
0 ImagesMeclocycline is a tetracycline antibiotic with broad-spectrum antibacterial activities, preventing skin bacterial infections such as acne vulgarisis.
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Tetracycline-d6
0 ImagesCat. No.: HY-A0107SCAS No.: 2373374-42-4Tetracycline-d6 is the deuterium labeled Tetracycline. Tetracycline is a broad-spectrum antibiotic, exhibiting activity against a wide range of gram-positive and gram-negative bacteria.
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Oxytetracycline dihydrate
0 ImagesOxytetracycline dihydrate is an antibiotic belonging to the tetracycline class. Oxytetracycline dihydrate potent inhibits Gram-negative and Gram-positive bacteria. Oxytetracycline dihydrate is a protein synthesis inhibitor and prevents the binding from aminoacil-tRNA to the complex m-ribosomal RNA. Oxytetracycline dihydrate also possesses anti-HSV-1 activity.
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Eravacycline
0 ImagesCat. No.: HY-16980CAS No.: 1207283-85-9Synonyms: TP-434Eravacycline is a potent and broad-spectrum antibacterial agent.
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Omadacycline mesylate
0 ImagesCat. No.: HY-14865ACAS No.: 1196800-40-4Synonyms: PTK 0796 mesylate; Amadacycline mesylateOmadacycline (PTK 0796) mesylate, a first-in-class orally active aminomethylcycline antibacterial, is a member of the tetracycline class of antibiotics. Omadacycline mesylate acts through the inhibition of bacterial protein synthesis by binding to the 30S ribosomal subunit. Omadacycline mesylate possesses broad-spectrum antibacterial activity against aerobic and anaerobic Gram-positive and Gram-negative bacteria, as well as atypical bacteria. Omadacycline mesylate can be used for the research of acute bacterial skin and skin-structure infections, community-acquired pneumonia, and urinary tract infections.
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Oxytetracycline calcium
0 ImagesOxytetracycline calcium is an antibiotic belonging to the tetracycline class. Oxytetracycline calcium potently inhibits Gram-negative and Gram-positive bacteria. Oxytetracycline calcium is a protein synthesis inhibitor and prevents the binding from aminoacil-tRNA to the complex m-ribosomal RNA. Oxytetracycline calcium also possesses anti-HSV-1 activity.
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Doxycycline calcium
0 ImagesCat. No.: HY-N0565CCAS No.: 94088-85-4Doxycycline calcium is an orally active highly lipophilic, tissue-permeable MMP inhibitor with broad-spectrum antibacterial activity. Doxycycline calcium is also a semi-synthetic antibiotic with chelating properties, which blocks bacterial protein synthesis and inhibits extracellular matrix degradation through interactions with zinc and calcium atoms. Doxycycline calcium also inhibits mitochondrial biogenesis, translation, and the expression of respiratory chain proteins. Doxycycline calcium induces apoptosis, inhibits autophagy and EMT, downregulates stem cell markers, and activates the PI3K-AKT pathway, thereby effectively inhibiting the viability and proliferation of cancer cells such as breast cancer cells. Doxycycline calcium also promotes the survival and self-renewal of embryonic stem cells and neural stem cells, and reduces the frequency of medium changes in culture. Doxycycline calcium has been applied in studies related to breast cancer, prostate cancer, bladder cancer, and other cancers.
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Chlortetracycline
0 ImagesChlortetracycline (7-Chlorotetracycline) is an orally active, effective and selectively methanogenic bacteria inhibitor with bactericidal effects. Chlortetracycline is also a antibiotic that acts by inhibiting bacterial protein synthesis. Additionally, Chlortetracycline is a specific and potent calcium ionophore antibiotic, inhibiting binding of aminoacyl-tRNA to ribosomes.
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Demecycline
0 ImagesDemecycline, a tetracycline antibiotic, is the C6-demethylated derivative of Tetracycline (HY-A0107) against bacterial infections including pneumonia and other respiratory tract infections.
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Cloxacillin
0 ImagesCloxacillin is an orally active antibacterial agent and β-lactamase inhibitor with an IC50 of 0.04 µM. Cloxacillin can suppress the S. aureus-induced inflammatory response by inhibiting the activation of MAPKs, NF-кB and NLRP3-related proteins.
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Tetracycline 10-O-ß-D-galactopyranoside
0 ImagesCat. No.: HY-W714019CAS No.: 319426-63-6Tetracycline 10-O-ß-D-galactopyranoside is a broad antibiotic.
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Minocycline-d6 hydrochloride
0 ImagesCat. No.: HY-17412SCAS No.: 1035979-33-9Minocycline-d6 hydrochloride is deuterated labeled Minocycline hydrochloride (HY-17412). Minocycline hydrochloride is an orally active, potent and BBB-penetrated semi-synthetic tetracycline antibiotic. Minocycline hydrochloride is a hypoxia-inducible factor (HIF)-1α inhibitor. Minocycline hydrochloride shows anti-cancer, anti-inflammatory, and glutamate antagonist effects. Minocycline hydrochloride reduces glutamate neurotransmission and shows neuroprotective properties and antidepressant effects. Minocycline hydrochloride inhibits bacterial protein synthesis through binding with the 30S subunit of the bacterial ribosome, resulting in a bacteriostatic effect.
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Sarecycline
0 ImagesCat. No.: HY-16770CAS No.: 1035654-66-0Synonyms: P-005672Sarecycline is an orally effective narrow-spectrum tetracycline derivative antibiotic. Sarecycline has anti-inflammatory activity. Sarecycline inhibits the activity of Gram-positive bacteria and several types of keratobacterium acnes. Sarecycline interferes with tRNA accommodation and tethers mRNA to the 70S ribosome. Sarecycline can be used to study moderate to severe acne.
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(4S,5S,6S,12aS)-Oxytetracycline
0 ImagesCat. No.: HY-149154CAS No.: 423769-22-6(4S,5S,6S,12aS)-Oxytetracycline is a broad-spectrum antibiotic that can inhibit the synthesis of protein in bacteria. (4S,5S,6S,12aS)-Oxytetracycline is an important member of the bacterial aromatic polyketone family, a type of natural product with diverse structures.
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4-Epianhydrotetracycline hydrochloride
0 Images4-Epianhydrotetracycline hydrochloride is a major intermediate product of Tetracycline (HY-A0107). 4-Epianhydrotetracycline hydrochloride shows lethal effects and induces cell apoptosis of zebrafish embryos. 4-Epianhydrotetracycline hydrochloride inhibits Shewanella, E. coli and P. aeruginosa with MIC values of 2, 1 and 64 mg/L, respectively.
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Chlortetracycline-d6 hydrochloride
0 ImagesCat. No.: HY-B1327SSynonyms: 7-Chlorotetracycline-d6 hydrochlorideChlortetracycline-d6 (hydrochloride) is the deuterium labeled Chlortetracycline hydrochloride. Chlortetracycline hydrochloride (7-Chlorotetracycline hydrochloride) is a specific and potent calcium ionophore antibiotic, inhibits binding of aminoacyl-tRNA to ribosomes.
