Drug Derivative
Drug derivative
Drug derivatives are derived from parent compounds. They replace or add atoms and groups through chemical reactions to optimize the various properties of the parent compound and reduce side effects. The application of drug derivatives provides a diverse compound library for drug research and development and accelerates the discovery of new drugs. For example, urea derivatives Glibenclamide can prolong the blood sugar-lowering effect of anti-diabetic drugs.
References:
- [1]. Vardanyan RS, et al. Fentanyl-related compounds and derivatives: current status and future prospects for pharmaceutical applications. Future Med Chem. 2014 Mar;6(4):385-412.x
- [2]. Ghosh AK, et al. Urea Derivatives in Modern Drug Discovery and Medicinal Chemistry. J Med Chem. 2020 Mar 26;63(6):2751-2788.x
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Drug Derivative Related Products (4062)
Related Products (4062)
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Creticoside A
0 ImagesCat. No.: HY-N17050CAS No.: 34336-00-0Creticoside A is a natural diterpene.
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Methyl-celastrol
0 ImagesCat. No.: HY-186294CAS No.: 1810867-99-2Methyl-celastrol is a Celastrol (HY-13067) derivative and triterpenoid compound. Methyl-celastrol exists in Celastrus hypoleucus (Oliv) Warb f argutior Loes and other Celastraceae plants. Methyl-celastrol induces weight loss, reduces body fat, decreases food intake and improves glucose homeostasis. Methyl-celastrol is applicable to obesity-related research.
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Dodovisone D
0 ImagesCat. No.: HY-N16883CAS No.: 1616683-53-4Dodovisone D is a natural flavonoid.
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Phomopsin D
0 ImagesCat. No.: HY-N16440CAS No.: 175617-09-1Phomopsin D, a mycotoxin, is a derivative of Phomopsin A (HY-N6793). Phomopsin A is a cyclic hexapeptide mycotoxin isolated from the fungus Phomopsis leptostomiformis. Phomopsin A is a noncompetitive inhibitor of the binding of radiolabeled vincristine to tubulin.
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Sanggenol G
0 ImagesCat. No.: HY-N16799CAS No.: 202526-52-1Sanggenol G is a natural phenolic compound.
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GW-678248
0 ImagesCat. No.: HY-116732CAS No.: 329939-64-2Synonyms: GW-8248GW-678248 is an active compound.
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Thalifaramine
0 ImagesCat. No.: HY-N16871CAS No.: 105437-16-9Thalifaramine is a natural alkaloid.
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Desulfoglucoraphanin
0 ImagesCat. No.: HY-W702980CAS No.: 287966-62-5Desulfoglucoraphanin is an aliphatic glucosinolate present in Brassica rapa L. ssp. pekinensis. Desulfoglucoraphanin is the desulfated derivative of Glucoraphanin (HY-N4068).
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6''-O-β-D-Apiofuranosylapterin
0 ImagesCat. No.: HY-N13833CAS No.: 2188162-94-76''-O-β-D-Apiofuranosylapterin is a natural coumarin.
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Lysidine
0 ImagesCat. No.: HY-128401CAS No.: 144796-96-3Synonyms: 2-Lysylcytidine
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15-Deoxy-Δ12,14-Prostaglandin J2-2-glyceryl ester
0 ImagesCat. No.: HY-176243CAS No.: 1947405-90-415-Deoxy-Δ12,14-Prostaglandin J2-2-glyceryl ester is a derivate of 15-Deoxy-Δ-12,14-prostaglandin J2 (HY-108568). 15-Deoxy-Δ-12,14-prostaglandin J2 (15d-PGJ2) is a cyclopentenone prostaglandin and a metabolite of PGD2. 15-Deoxy-Δ-12,14-prostaglandin J2 is a selective PPARγ (EC50 of 2 µM) and a covalent PPARδ agonist. 15-Deoxy-Δ-12,14-prostaglandin J2 promotes efficient differentiation of C3H10T1/2 fibroblasts to adipocytes with an EC50 of 7 μM.
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Hexadecyl (E)-ferulate
0 ImagesCat. No.: HY-N17076CAS No.: 158306-36-6Hexadecyl (E)-ferulate is a natural phenylacetylene.
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Mukonal
0 ImagesCat. No.: HY-N16752CAS No.: 20323-67-5Mukonal is a natural alkaloid.
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RU 24926
0 ImagesCat. No.: HY-116727CAS No.: 65934-61-4RU 24926 is an active compound.
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Cys-TAT(47-57)
0 ImagesCat. No.: HY-P1801CAS No.: 583836-55-9Synonyms: Cys-[HIV-Tat (47-57)]
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5-Chloro-2-thiothinone hydrochloride
0 ImagesCat. No.: HY-158927CAS No.: 2903386-66-1Synonyms: 5-Chloro bk-MPA hydrochloride; 5Cl-bk-MPA hydrochloride5-Chloro-2-thiothinone (5-Chloro bk-MPA) hydrochloride is structurally similar to known stimulants.
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Methyl (9Z,12Z,14E)-16-hydroxy-9,12,14-octadecatrienoate
0 ImagesCat. No.: HY-N17464CAS No.: 65179-55-7Methyl (9Z,12Z,14E)-16-hydroxy-9,12,14-octadecatrienoate is an esterified oxylipin and esterified hydroxy linolenic acid (HOT-Me) that can be found in potato tubers (Solanum tuberosum L. cv. Bintje).
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Methyl-d3 tetradecanoate
0 ImagesCat. No.: HY-W708886CAS No.: 60670-33-9Methyl-d3 tetradecanoate is the deuterium labeled Methyl myristate (HY-W004288). Methyl myristate is a saturated fatty acid methyl ester obtained from the esterification of myristic acid. Methyl myristate shows a high melanin induction in B16F10 melanoma.
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12-Hydroxy-4,11(13)-eudesmadien-15-al
0 ImagesCat. No.: HY-N17286CAS No.: 76235-90-012-Hydroxy-4,11(13)-eudesmadien-15-al (Compound 10) is an eudesane-type sesquiterpene isolated from the leaves of Ambrosia arborescens.
