Drug Derivative
Drug derivative
Drug derivatives are derived from parent compounds. They replace or add atoms and groups through chemical reactions to optimize the various properties of the parent compound and reduce side effects. The application of drug derivatives provides a diverse compound library for drug research and development and accelerates the discovery of new drugs. For example, urea derivatives Glibenclamide can prolong the blood sugar-lowering effect of anti-diabetic drugs.
References:
- [1]. Vardanyan RS, et al. Fentanyl-related compounds and derivatives: current status and future prospects for pharmaceutical applications. Future Med Chem. 2014 Mar;6(4):385-412.x
- [2]. Ghosh AK, et al. Urea Derivatives in Modern Drug Discovery and Medicinal Chemistry. J Med Chem. 2020 Mar 26;63(6):2751-2788.x
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Drug Derivative Related Products (4062)
Related Products (4062)
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Dexamethasone dipropionate
0 ImagesCat. No.: HY-W740983CAS No.: 55541-30-5Dexamethasone dipropionate is a Dexamethasone (HY-14648) ester. Dexamethasone dipropionate can be used in the research of osteoarthritis.
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Decumbenine
0 ImagesCat. No.: HY-N18371CAS No.: 76733-83-0Decumbenine (2-1) is an isoquinoline alkaloid found in Corydalis decumbens (Thunb.) Pers.
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Tubercidin 5'-triphosphate
0 ImagesCat. No.: HY-134248CAS No.: 10058-66-9Synonyms: 7-Deazaadenosine 5'-triphosphate
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Anticancer agent 94
0 ImagesCat. No.: HY-152085Anticancer agent 94 is a 4-Hydroxycoumarin derivative. Anticancer agent 94 can inhibit invasion and migration of lung cancer cells by modulating expression of epithelial-mesenchymal transition (EMT) effectors.
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BMY-30047
0 ImagesCat. No.: HY-19074CAS No.: 83860-24-6BMY-30047 is a retinoic acid derivative. BMY-30047 has topical retinoid activity. BMY-30047 has relative low local and systemic toxicity.
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6-Aminocaproic acid hydrochloride
0 ImagesSynonyms: EACA hydrochloride; Epsilon-Amino-n-caproic Acid hydrochloride; 6-Aminohexanoic acid hydrochloride6-Aminocaproic acid hydrochloride, a monoamino carboxylic acid, is a potent and orally active inhibitor of plasmin and plasminogen. 6-Aminocaproic acid is a potent antifibrinolytic agent. 6-Aminocaproic acid prevents clot lysis through the competitive binding of lysine residues on plasminogen, inhibiting plasmin formation and reducing fibrinolysis. 6-Aminocaproic acid can be used for the research of bleeding disorders.
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cis-Oxyresveratrol 3'-O-β-D-glucopyranoside
0 ImagesCat. No.: HY-N3517ACAS No.: 2493206-35-0cis-Oxyresveratrol 3'-O-β-D-glucopyranoside is a derivative of Oxyresveratrol (HY-N1430) and can be found in mulberry branches. cis-Oxyresveratrol 3'-O-β-D-glucopyranoside exhibits antioxidant activity.
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Lycoramine
0 ImagesLycoramine is a blood-brain barrier-penetrating Acetylcholinesterase inhibitor and Galanthamine (HY-76299) derivative. Lycoramine induces Amyloid-beta plaque clearance. Lycoramine induces reversal of cognitive decline and memory improvement. Lycoramine can be used for research on Alzheimer's disease and myasthenia gravis.
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Dendroside C
0 ImagesCat. No.: HY-N21803CAS No.: 526222-16-2Dendroside C is a sesquiterpene glycoside found in the stems of Dendrobium nobile.
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Anticancer agent-364
0 ImagesCat. No.: HY-189286Anticancer agent-364 is a phenylalanine-derived hydrazone heterocyclic compound that exhibits selective cytotoxicity against NSCLC lung cancer cells. Anticancer agent-364 inhibits VEGF-A, VEGFR-1, and VEGFR-2, increases caspase-3/7, caspase-8, and caspase-9 activity, and induces apoptosis. Anticancer agent-364 can be used for research on non-small cell lung cancer.
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(20S,24S)-20,24-Dihydroxy-3,4-secodammara-4(28),25-dien-3-oic acid
0 ImagesCat. No.: HY-N17437CAS No.: 117732-41-9(20S,24S)-20,24-Dihydroxy-3,4-secodammara-4(28),25-dien-3-oic acid is a secodammarane-type triterpenic acid that can be found in the male flowers of Alnus japonica.
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Rubiarbonol A
0 ImagesCat. No.: HY-N17645CAS No.: 130288-59-4Rubiarbonol A is a natural product that can be found in Rubia cordifolia?L..
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1β-Hydroxy-12-noreremophila-6,9-diene-8,11-dione
0 ImagesCat. No.: HY-N17173CAS No.: 161127-52-21β-Hydroxy-12-noreremophila-6,9-diene-8,11-dione is a natural sesquiterpene.
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CHNQD-00824
0 ImagesCat. No.: HY-177869CAS No.: 2222643-74-3CHNQD-00824 is a Terphenyllin (HY-119821) derivative with potent anticancer effect. CHNQD-00824 inhibits the proliferation and migration of cancer cells via DNA damage. CHNQD-00824 triggers apoptosis and inhibits Doxycin Hydrochloride (DOX)-induced liver-specific enlargement in zebrafish embryos. CHNQD-00824 can be used for cancer research, such as liver and breast cancer.
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3-Methylcathinone hydrochloride
0 ImagesCat. No.: HY-179366CAS No.: 1198299-84-1Synonyms: 3-MMC hydrochloride3-Methylcathinone (3-MMC) hydrochloride is an analogue of a psychoactive substance.
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Imolamine
0 ImagesImolamine is a potent antiplatelet aggregation agent, is a phenyl aminoxidiazole derivative. Imolamine has the potential for the research of coronary heart disease.
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cis-Upunaphenol K
0 ImagesCat. No.: HY-N16859CAS No.: 879897-47-9cis-Upunaphenol K is a natural phenolic compound.
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RP-182-PEG3-K(palmitic acid)-NH2
0 ImagesCat. No.: HY-169089RP-182-PEG3-K palmitic acid-NH2 (Compound 1a) is a fatty acid derivative of the immunomodulatory peptide RP-182. RP-182-PEG3-K palmitic acid-NH2 inhibits CD206high M2-like macrophage (IC50 of 3.2 μM) and induces phagocytosis. RP-182-PEG3-K palmitic acid-NH2 exhibits antitumor efficacy in mouse B16 melanoma allografts.
