CHNQD-00824
CHNQD-00824 is a Terphenyllin (HY-119821) derivative with potent anticancer effect. CHNQD-00824 inhibits the proliferation and migration of cancer cells via DNA damage. CHNQD-00824 triggers apoptosis and inhibits Doxycin Hydrochloride (DOX)-induced liver-specific enlargement in zebrafish embryos. CHNQD-00824 can be used for cancer research, such as liver and breast cancer.
For research use only. We do not sell to patients.
- CAS No.: 2222643-74-3
- Formula: C26H26O5
- Molecular Weight:418.48
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Biological Activity
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| A549 | IC50 |
0.25 μM
Compound: 29
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Cytotoxicity against human A549 cells by SRB assay
Cytotoxicity against human A549 cells by SRB assay
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[PMID: 29407953] |
| HeLa | IC50 |
0.15 μM
Compound: 29
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Cytotoxicity against human HeLa cells by SRB assay
Cytotoxicity against human HeLa cells by SRB assay
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[PMID: 29407953] |
| HepG2 | IC50 |
0.43 μM
Compound: 29
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Cytotoxicity against human HepG2 cells by SRB assay
Cytotoxicity against human HepG2 cells by SRB assay
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[PMID: 29407953] |
CHNQD-00824 (72 h) exhibits potent inhibitory activity against a panel of cancer cells, including RCC4, HeLa, Hep G2, U2OS, U251, DU145, TE-1, BT549, HCT8, and MCF7 cells, with IC50 values of 2.65, 0.45, 7.64, 0.44, 5.43, 0.91, 4.35, 0.16, 0.61, and 3.66 μM[1].
CHNQD-00824 (0-8 μM, 7-13 days) dose-dependently inhibits colony formation in BT549 cells[1].
CHNQD-00824 (0-10 μM, 0-24 h) inhibits cell migration of BT549 cells in a time- and concentration dependent manner[1].
CHNQD-00824 (0-8 μM, 24 h) induces G2 phase cell cycle arrest, and induces apoptosis via DNA damage in a concentration- and caspase-dependent manner in BT549 cells[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:BT549 cells
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Concentration:0, 0.25, 0.5, and 1 μM
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Incubation Time:24 h
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Result:Decreased percentage of cells in the G2 phase in a dose-dependent manner from 31.78% to 10.44%.
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Cell Line:BT549 cells
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Concentration:0, 1, 5, and 10 μM
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Incubation Time:0, 12, and 24 h
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Result:Showed no significant effect on the cell viability after 12 h treatment.
Significantly inhibited cell migration at concentrations of 5 and 10 μM.
Exhibited a notable inhibitory effect on cell migration after 24 h at concentrations of 1, 5, and 10 μM.
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Cell Line:BT549 cells
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Concentration:0, 2, 4, 5, and 8 μM
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Incubation Time:7, and 13 days
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Result:Dose-dependently reduced the formation of colonies after 13 days.
Almost completely inhibited cell proliferation at a concentration of 5 μM after 7 days.
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Cell Line:BT549 cells
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Concentration:0, 0.25, 0.5, and 1 μM
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Incubation Time:0, 12, and 24 h
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Result:Resulted in a dose-dependent increase in the percentage of apoptotic cells (0.25, 0.5, and 1 μM), reaching 10.66%, 14.67%, and 23.50%, respectively.
Significantly induced apoptosis in a concentration-dependent manner.
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Cell Line:BT549 cells
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Concentration:0, 0.5, 2, and 8 μM
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Incubation Time:24 h
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Result:Led to an increase in the levels of cleaved-PARP1 (C-PARP1) and Cytochrome C (Cyto C) at 0.5, 2, and 8 μM.
Increased the level of cleaved-caspase 3 (C-Cas3) at the concentrations of 2 and 8 μM.
Increased the pre-apoptotic protein BAD at the concentrations of 8 μM.
Increased γH2AX levels in a concentration-dependent manner.
CHNQD-00824 (1.25-5 μM, from day 3 to day 7 post-fertilization) inhibits DOX-induced liver-specific enlargement in zebrafish embryos in a dose-dependent manner[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 2222643-74-3
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Molecular Weight 418.48
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Formula C26H26O5
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SMILES
OC1=CC=C(C2=C(C=C(C3=CC=C(C=C3)OCC=C)C(OC)=C2OCC=C)OC)C=C1
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
CHNQD-00824 Related Classifications
HY-177869 Related Classifications
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