Flavivirus

Flavivirus is a group of single-stranded positive-sense RNA viruses that are mainly transmitted by arthropods such as mosquitoes and ticks. The viral particles of the Flavivirus are spherical, with a diameter of approximately 40-60 nanometers and have an envelope. The envelope is embedded with spike glycoproteins, which play a crucial role in the recognition and binding process between the virus and host cells. Flavivirus contains a variety of viruses, such as the yellow fever virus and the dengue virus, etc., which can cause a variety of serious diseases and have a significant impact on global public health security^[1].

References:

[1]. Chong HY, et al. Flavivirus infection-A review of immunopathogenesis, immunological response, and immunodiagnosis. Virus Res. 2019 Dec;274:197770. [Content Brief]

Flavivirus Inhibitors (109)

Flavivirus Related Products (188)
Antibodies (1)

Cat. No.	Product Name	Effect	Purity	Chemical Structure

HY-B0433B

Quinine hemisulfate
Quinine hemisulfate is an orally active alkaloid extracted from cinchona bark and can be used in anti-malarial studies. Quinine hemisulfate is a potassium channel inhibitor that inhibits WT mouse Slo3 (K_Ca5.1) channel currents evoked by voltage pulses to +100 mV with an IC₅₀ of 169 μM.

HY-150600

NS2B/NS3-IN-7	Inhibitor	98.59%
NS2B/NS3-IN-7 (compound 26) is a highly potent Zika virus NS2B-NS3 protease inhibitor with a K_i value of 2.33 nM. NS2B/NS3-IN-7 can reduce amounts of ZIKV-infected cells.

HY-155053

ZIKV-IN-6	Inhibitor
ZIKV-IN-6 (compound 22) is an inhibitor of Zika virus (ZIKV), with low cytotoxicity (CC₅₀＞50 μM). ZIKV-IN-6 binds to ZIKV RdRp directly and inhibits viral RNA synthesis by ZIKV NS5. ZIKV-IN-6 suppresses the excessive inflammatory response and pyroptosis.

HY-B0421S2

Mycophenolic acid-¹³C₁₇	Inhibitor
Mycophenolic acid-13C17 (Mycophenolate-13C17) is the 13C labeled Mycophenolic acid (HY-B0421). Mycophenolic acid is a potent uncompetitive inosine monophosphate dehydrogenase (IMPDH) inhibitor with an EC50 of 0.24 μM. Mycophenolic acid demonstrates antiviral effects against a wide range of RNA viruses including influenza. Mycophenolic acid is an immunosuppressive agent. Antiangiogenic and antitumor effects.

HY-172772

Anti-PEDV agent 1	Inhibitor
Anti-PEDV agent 1 (Compound D39) is a highly effective anti-Porcine epidemic diarrhea virus (PEDV) agent with an EC₅₀ value of 0.09 μM. Anti-PEDV agent 1 blocks the early internalization of PEDV during viral entry by modulating intracellular Ca²⁺ homeostasis. Anti-PEDV agent 1 is promising for research of PEDV infections.

HY-B1120S

Temephos-d₁₂	Inhibitor
Temephos-d₁₂ is the deuterium labeled Temephos. Temephos (Temefos) is an orally active, blood-brain barrier-permeable organophosphate insecticide and AChE inhibitor. By irreversibly inhibiting AChE to induce cholinergic overactivation, Temephos effectively blocks larval development of Aedes aegypti (yellow fever mosquito) and Aedes albopictus (Asian tiger mosquito), and is commonly used in studies related to Dengue Virus, Zika Virus and other relevant pathogens. Temephos exhibits genotoxicity and neurodevelopmental toxicity, and may also cause liver injury, reproductive system abnormalities and cholinergic poisoning symptoms in mammals. Temephos tends to accumulate in adipose tissues and aquatic organisms, and is excreted via feces after metabolism through oxidation and hydrolysis. Note that CYP-mediated metabolic detoxification may reduce the actual larvicidal efficacy of Temephos against some mosquito species. Temephos can be used in research related to dengue fever, Zika virus disease, chikungunya and dracunculiasis.

HY-182674

VGD020	Inhibitor
VGD020 is a highly potent and selective Sec61 translocon inhibitor. VGD020 suppresses the expression of cell surface CD4 by inhibiting signal peptide-dependent co-translational ER translocation, interferes with the initiation of ER translocation of dengue virus polyprotein, and reduces the expression of Sortilin in breast cancer cells. VGD020 exhibits broad anti-flavivirus and anti-HIV activities. VGD020 can be used in research related to dengue virus infection, Zika virus infection, yellow fever virus infection, human immunodeficiency virus infection, and breast cancer.

HY-128788

ddhCTP	Inhibitor
ddhCTP is an endogenously produced pyrimidine base analog with a K_d of 17.0 nM for LLDH and an IC₅₀ of 55.8 μM for GAPDH. By inhibiting key metabolic enzymes such as GAPDH, ddhCTP reduces glycolytic flux and shifts metabolic flow toward the pentose phosphate pathway, thereby regulating the redox balance of cells. As a competitive CTP analog, ddhCTP terminates RNA synthesis by flavivirus RdRps and SARS-CoV-2 RdRp, and inhibits Zika virus replication in vivo. ddhCTP can be used in studies related to viral infections, COVID-19 and Zika virus infections.

HY-146193

Zika virus-IN-3	Inhibitor
Zika virus-IN-3 (Compd 7) is a Zika virus inhibitor, with an EC₅₀ of 3.4 μM .

HY-165485

OSL-95II	Inhibitor
OSL-95II is an antiviral agent. OSL-95II is a potent BVDV and WNV inhibitor. OSL-95II is a better inhibitor of HBV than SP169. OSL-95II inhibits dengue virus production.

HY-10396A

(2R,3S)-Emricasan	Inhibitor
(2R,3S)-Emricasan ((2R,3S)-PF 03491390) is an isomer of Emricasan (HY-10396). Emricasan is an orally active and irreversible pan-caspase inhibitor. Emricasan inhibits Zika virus (ZIKV)-induced increases in caspase-3 activity and protected human cortical neural progenitors.

HY-W010668R

Quinine sulfate hydrate (Standard)
Quinine (sulfate hydrate) (Standard) is the analytical standard of Quinine (sulfate hydrate). This product is intended for research and analytical applications. Quinine sulfate hydrate (2:1:4) is an orally active alkaloid extracted from cinchona bark and can be used in anti-malarial studies. Quinine sulfate hydrate (2:1:4) is a potassium channel inhibitor that inhibits WT mouse Slo3 (KCa5.1) channel currents evoked by voltage pulses to +100?mV with an IC50 of 169 μM.

HY-146417

Antiviral agent 19
Antiviral agent 19 (Compound 3) is a selective inhibitor against Zika virus infection with an EC₅₀ of 1.3 µM. Antiviral agent 19 has low cytotoxicity.

HY-161642

DENV-2/ZIKV-IN-1	Inhibitor
DENV-2/ZIKV-IN-1 (Compd 16a) is a dual inhibitor of Dengue virus (DENV) and Zika virus (ZIKV) with EC₅₀s of 1.4 and 2.4 μM, respectively.

HY-A0021S

Palonosetron-d₃ hydrochloride	Inhibitor
Palonosetron-d₃ hydrochloride is the deuterium labeled Palonosetron hydrochloride (HY-A0021). Palonosetron hydrochloride is a 5-HT3 antagonist primarily used to prevent acute, delayed, and overall chemotherapy-induced nausea and vomiting. In addition, Palonosetron hydrochloride exhibits moderate anti-flavivirus activity and potent anti-Zika virus activity in mammalian cells. Palonosetron hydrochloride also possesses antidepressant activity.

HY-152081

DENV-IN-7
DENV-IN-7, a flavone analog, is a dengue virus (DENV) inhibitor with an EC₅₀ value of 70 nM. DENV-IN-7 has low toxicity against normal cell and anti-dengue activity.

HY-P991767

Anti-Powassan virus E protein Antibody (POWV-63)	Inhibitor
Anti-Powassan virus E protein Antibody (POWV-63) reacts with the envelope (E) protein of Powassan virus (POWV). Anti-Powassan virus E protein Antibody (POWV-63) shows significant protection against POWV-SPO, TBFVs, and Langat virus (LGTV) in vivo. Recommend Isotype Controls: Mouse IgG2c kappa, Isotype Control (HY-P99981).

HY-P5642

Retrocyclin-101	Inhibitor
Retrocyclin-101 (RC-101) is a synthetic cyclic θ-defensin, a broad-spectrum antimicrobial peptide with anti-pathogen (covering viruses, bacteria and fungi) activity and anti-inflammatory activity. Retrocyclin-101 exhibits significant inhibitory activity against HIV, SARS-CoV-2, flaviviruses, influenza viruses, HSV-1/2, Staphylococcus aureus and others. Retrocyclin-101 inhibits TLR4 and TLR2-mediated signal transduction and reduces pro-inflammatory cytokine expression.

HY-15503

PHA-690509	Inhibitor
PHA-690509 is an anti-ZikV compound that inhibits ZikV replication. PHA-690509 is also a CDK inhibitor, and inhibits caspase-3 activity.

HY-N2076

Cephaeline hydrochloride	Inhibitor
Cephaeline hydrochloride ((-)-Cephaeline hydrochloride) is a phenolic alkaloid in Indian Ipecac roots. Cephaeline hydrochloride exhibits potent inhibition of both Zika virus (ZIKV) and Ebola virus (EBOV) infections.

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Flavivirus

Flavivirus Related Products (188)

Antibodies (1)

Flavivirus Related Products (188):