iGluR Agonist
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Epiallopregnanolone-d5
0 ImagesCat. No.: HY-124463S1Synonyms: 5α,3β-THDOC-d5Epiallopregnanolone-d5 (5α,3β-THDOC-d5) is deuterium labeled Epiallopregnanolone. Epiallopregnanolone (5α,3β-THDOC), a 3β-hydroxy neurosteroid, an antagonist at GABAA receptors and a NMDA receptor enhancer.
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Tulrampator (Standard)
0 ImagesCat. No.: HY-109046RCAS No.: 1038984-31-4Synonyms: CX-1632 (Standard); S-47445 (Standard)Tulrampator (Standard) is the analytical standard of Tulrampator (HY-109046). This product is intended for research and analytical applications. Tulrampator (S-47445) is an orally active selective AMPA receptor modulator. Tulrampator possesses procognitive, enhancing synaptic plasticity, anti-depressant-anxiolytic-like, procognitive and potential neuroprotective properties. Tulrampator can be used for research of alzheimer’s disease and in major depressive disorder.
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Omberacetam (Standard)
0 ImagesSynonyms: GVS-111 (Standard); SGS-111 (Standard)Omberacetam (Standard) is the analytical standard of Omberacetam. This product is intended for research and analytical applications. Omberacetam (GVS-111) is a medication promoted and prescribed in Russia and neighbouring countries as a nootropic.
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Apimostinel (Standard)
0 ImagesCat. No.: HY-102053RCAS No.: 1421866-48-9Synonyms: NRX-1074 (Standard); AGN-241660 (Standard)Apimostinel (Standard) is the analytical standard of Apimostinel (HY-102053). This product is intended for research and analytical applications. Apimostinel (NRX-1074; AGN-241660) is an orally active NMDA receptor partial agonist.
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LY339434
0 ImagesCat. No.: HY-114550CAS No.: 219566-62-8LY339434 is a potent and selective agonist for the hydrochloride receptor GluR5. LY339434 affects the rapid death of neurons through n-methyl-D-aspartate (NMDA) receptors.
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Quinolinic acid-13C7
0 ImagesCat. No.: HY-100807S1CAS No.: 1346642-91-8Quinolinic acid-13C7 is the 13C labeled Quinolinic acid (HY-100807). Quinolinic acid, an endogenous metabolite of tryptophan, is a N-methyl-D-aspartate receptor (NMDA receptor) agonist. Quinolinic acid increases glutamate efflux, induces the generation of ROS, activates nitric oxide synthase, produces excessive NO, leading to calcium ion influx and neuronal apoptosis.
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Sunifiram (Standard)
0 ImagesSynonyms: DM-235 (Standard)Sunifiram (Standard) is the analytical standard of Sunifiram. This product is intended for research and analytical applications. Sunifiram (DM-235) is an ampakine-like compound and an agonist of AMPA receptor with oral activity. Sunifiram can increase the release of acetylcholine in the rat cerebral cortex and exhibits potent cognitive enhancement effects with better nootropic activity compared to piracetam (HY-B0585). Sunifiram is promising for research in neurodegenerative diseases such as mild cognitive impairment (MCI) and Alzheimer's disease (AD).
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Tianeptine sodium salt (Standard)
0 ImagesTianeptine sodium salt (Standard) is the analytical standard of Tianeptine sodium salt (HY-90003A). This product is intended for research and analytical applications. Tianeptine sodium salt is an atypical antidepressant. Tianeptine sodium salt is a moderate-intensity agonist of the μ-opioid receptor (MOR), and to a lesser extent, is an agonist of the δ-opioid receptor (DOR). Tianeptine sodium salt is a glutamate modulator that can enhance AMPA receptor and antagonize NMDA receptor. Tianeptine sodium salt increases sensitivity of the α1 adrenergic receptor, which only manifests in chronic treatment. Tianeptine sodium salt exerts neuroprotective effects under stress/inflammation-induced conditions, exhibiting anti-inflammatory and antioxidant properties. Tianeptine sodium salt inhibits MMP-9 by suppressing the PI3K/Akt-mediated NF-κB pathway. Tianeptine sodium salt can be used to alleviate symptoms of depression and anxiety, but does not cause sedative effects.
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(RS)-AMPA (Standard)
0 ImagesCat. No.: HY-100815BRCAS No.: 77521-29-0Synonyms: (±)-AMPA (Standard)(RS)-AMPA (Standard) is the analytical standard of (RS)-AMPA. This product is intended for research and analytical applications. (RS)-AMPA ((±)-AMPA) is a glutamate analogue and a potent and selective excitatory neurotransmitter L-glutamic acid agonist. (RS)-AMPA does not interfere with binding sites for kainic acid or NMDA receptors.
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Zelquistinel (Standard)
0 ImagesCat. No.: HY-109164RCAS No.: 2151842-64-5Synonyms: AGN-241751 (Standard); GATE-251 (Standard)Zelquistinel (Standard) is the analytical standard of Zelquistinel (HY-109164). This product is intended for research and analytical applications. Zelquistinel (AGN-241751) is the orally active N-methyl-D-aspartate (NMDA) receptor partial agonist used for the research of depression, anxiety and other related psychiatric disorders.
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SYM 2081 (Standard)
0 ImagesCat. No.: HY-101310RCAS No.: 31137-74-3SYM 2081 (Standard) is the analytical standard of SYM 2081 (HY-101310). This product is intended for research and analytical applications. SYM 2081 is a kainate receptor agonist. SYM 2081 is a substrate of EAAT1 (Km of 54 μM). SYM 2081 inhibits EAAT2-mediated glutamate transport (Kb is 3.4 μM in Xenopus oocytes), modulates Apoptotic signaling pathways (increases Bcl-2 and decreases Bax/caspase-3 expression). SYM 2081 exhibits neuroprotective activity. SYM 2081 can be used in the study of hypoxic-ischemic brain damage and inflammatory or neuropathic pain.
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LY-503430
0 ImagesCat. No.: HY-122164CAS No.: 625820-83-9LY-503430 is an orally active AMPA receptor positive allosteric modulator (PAM). LY-503430 can be used for the study of Parkinson's disease.
