Lipase Inhibitor

hPL-IN-2 (compound 2u) is a potent, reversible, and non-competitive inhibitor of pancreatic lipase (IC₅₀: 1.63 μM) and can be used in anti-obesity research.

Lipstatin is a pancreatic lipase inhibitor (IC₅₀=0.14 μM), whose structure is closely related to the known inhibitor, Esterastin. Lipstatin inhibits the absorption of triglycerides without affecting the absorption of oleic acid. Lipstatin has no inhibitory effects on other pancreatic enzymes, such as phospholipase A2 and trypsin (<200 μM).

Endothelial lipase inhibitor-1 is a potent endothelial lipase inhibitor with an IC₅₀ of 49 nM.

1,2-Dioleoyl-3-behenoylglycerol (BOO) inhibits pancreatic lipase activity. 1,2-Dioleoyl-3-behenoylglycerol prevents the deposition of visceral fat and hepatic triacylglycerol (TAG).

Neotheaflavin, from black tea, inhibits pancreatic lipase.

Cetilistat (Standard) is the analytical standard of Cetilistat. This product is intended for research and analytical applications. Cetilistat (ATL-962), an inhibitor of pancreatic lipase, acts as an effective anti-obesity agent. Cetilistat inhibits rat and human pancreatic lipase activity with IC50s of 54.8 nM, and 5.95 nM, respectively.

Acanthopanaxoside A, a triterpenoid saponin, has pancreatic lipase inhibitory action.

Royleanonic acid is an abietan-type diterpene found in the leaves of Salvia officinalis L. Royleanonic acid is a porcine pancreatic lipase inhibitor with an IC₅₀ of 35 μg/mL.

URB754 is a potent inhibitor of the endocannabinoid-deactivating enzyme monoacylglycerol lipase (MGL) with an IC₅₀ of 200 nM.

Dehydrocholic acid (Dehydrocholate) (Standard) is the analytical standard of Dehydrocholic acid (HY-B1393). This product is intended for research and analytical applications. Dehydrocholic acid (Dehydrocholate) is an orally active hydrocholeretic agent. Dehydrocholic acid modulates Autophagy, reduces serum amylase and lipase levels. Dehydrocholic acid has the effects of promoting choleretic function, protecting the liver, reducing pancreatic damage, and regulating cholesterol metabolism. Dehydrocholic acid can be used in the study of acute biliary pancreatitis and obstructive jaundice.

MAGL-IN-222 (Compound ZQ-7) is a covalent inhibitor targeting monoacylglycerol lipase (MAGL) with an IC₅₀ of 42.31 μM. MAGL-IN-222 can reduce the breakdown of 2-arachidonoylglycerol (2-AG) and increase the intracellular 2-AG level, thereby inhibiting the proliferation and migration of MDA-MB-231 breast cancer cells. MAGL-IN-222 can be used in the research of breast cancer and other related diseases.

Pungenin is a compound that can be isolated from Leontopodium leontopodioides. Pungenin exhibits lipase inhibitory activity. Pungenin reuduces triglyceride absorption.

Dehydrodicatechin A is a biflavan catechin dimer and antioxidant. Dehydrodicatechin A is isolated from the roots of Hagenia abyssinica, the stem bark of Choerospondias axillaries, the stems of Entada phaseoloides, and Calligonum comosum. Dehydrodicatechin A exhibits ABTS⁺ radical cation, DPPH, ABTS, and superoxide anion radical scavenging activities, as well as ferric reducing/antioxidant power. Dehydrodicatechin A inhibits Lipase. Dehydrodicatechin A is used in studies on polycystic ovary syndrome, Ehrlich ascites, and Doxorubicin (HY-15142)-induced cardiotoxicity.

SOL-116 is a humanized anti-BSSL antibody. SOL-116 blocks BSSL from binding to monocytes. SOL-116 reduces the severity of Pristane (HY-N7819)-induced arthritis in rats.

LAS195319 is an orally active and potent inhibitor against PI3Kδ with an IC₅₀ value of 0.5 nM. LAS195319 is also a highly selective inhibitor against an extensive panel of proteins, lipid kinases and GPCRs. LAS195319 causes an inhibition of neutrophil and eosinophil infiltration. LAS195319 is promising for research of respiratory diseases such as asthma and chronic obstructive pulmonary disease (COPD).

α-Glucosidase-IN-123, a hybrid derivative of baicalein and cinnamic acid, acts as an inhibitor of α-glucosidase. α-Glucosidase-IN-123 enhances glucose uptake in insulin-resistant hepatocytes without significant cytotoxicity. α-Glucosidase-IN-123 exhibits lipase inhibitory activity and DPPH free radical scavenging activity, and it can be used in the research of type 2 diabetes.

(1,5E,11E)-Tridecatriene-7,9-diyne-3,4-diacetate, isolated from the ethanol extract of Atractylodes lancea rhizome, displays significant lipase inhibition with an IC₅₀ value of 23.9 µg/mL. Antiobesity Effect.

(3Z,5E,11E)-3,5,11-Tridecatriene-7,9-diyn-1-ol, 1-acetate is a polyacetylene found in Atractylodes lancea rhizome. (3Z,5E,11E)-3,5,11-Tridecatriene-7,9-diyn-1-ol, 1-acetate inhibits human pancreatic lipase inhibitor with an IC₅₀ of 39.91 μM. (3Z,5E,11E)-3,5,11-Tridecatriene-7,9-diyn-1-ol, 1-acetate can be used for the research of obesity.

Morusalnol A is a arylbenzofuran derivative found in the root bark of Morus alba. Morusalnol A is a pancreatic lipase inhibitor with a porcine pancreatic lipase IC₅₀ of 0.71 μM. Morusalnol A inhibits pancreatic lipase activity. Morusalnol A can be used for the research of obesity.

Ebelactone A is a mycolic acid β-lactone, which exhibits inhibitory activity for esterase, lipase, fMet aminopeptidase (fMet AP) and PNBase, with IC₅₀s of 56, 3, 8 and 7.5 μM, respectively. Ebelactone A inhibits cutinase, exhibits plants protective potency against Erysiphe graminis.