2. Signaling Pathways
  3. Immunology/Inflammation
  4. MHC
  5. MHC Ligand

MHC Ligand

MHC Isoform Comparison

MHC Ligands (8):

Cat. No. Product Name Effect Purity
  • HY-126855
    Cholic acid 7-sulfate
    		Ligand 99.92%
    Cholic acid 7-sulfate (7-Sulfocholic acid) is a selective agonist targeting TGR5 (EC50=0.17 μM) and a ligand for MHC class I-related protein (MR1). As a gut-restricted TGR5 agonist, cholic acid 7-sulfate binds to TGR5 on enteroendocrine L cells, induces GLP-1 secretion, and improves glucose tolerance in a TGR5-dependent manner. Cholic acid 7-sulfate also acts as an endogenous ligand for MR1, promoting the survival of mucosal-associated invariant T cells MAIT and the expression of homeostatic gene signatures, affecting MAIT cell development and function. Cholic acid 7-sulfate is mainly used in the research of diabetes and MAIT cell-related immune regulation.
  • HY-P6312
    ESAT6 Epitope
    		Ligand
    ESAT6 Epitope is a ESAT6 CD4+ T cell epitope. ESAT6 Epitope binds to MHC class I molecules with an IC50 value of approximately 180 nM. ESAT6 Epitope has weak immunogenicity. ESAT6 Epitope can be used in studies related to pulmonary tuberculosis.
  • HY-P5499
    CMV pp65(13-27)
    		Ligand 98.05%
    CMV pp65(13-27) is a biological active peptide. (This peptide is derived from amino acid residues 13 to 27 of the 65k lower matrix phosphoprotein of the human cytomegalovirus. It contains a nine-amino-acid sequence (LGPISGHVL) that matches the consensus binding motif for a major histocompatibility complex H2-Dd T-cell epitope.)
  • HY-P11340
    VMAPRTLFL
    		Ligand
    VMAPRTLFL is a 9-mer peptide derived from the signal peptide of HLA-G and can serve as a peptide ligand for HLA-E. VMAPRTLFL plays a crucial role in regulating the functions of adaptive natural killer (NK) cells. Specifically, VMAPRTLFL enriches FcεRγ- adaptive NK cells, upregulates the expression of CD25, and enhances their proliferative activity, antibody-dependent cellular cytotoxicity (ADCC), and IFN-γ release. VMAPRTLFL can be used in research related to human cytomegalovirus (HCMV) infection, transplant rejection, and pregnancy immunity.
  • HY-P11390
    BAGE (2-10)
    		Ligand
    BAGE (2-10) is a BAGE-encoded nonapeptide. BAGE (2-10) binds to the HLA-Cw*1601 molecule to form an antigen recognized by autologous cytotoxic T lymphocytes. BAGE (2-10) can be used in melanoma research.
  • HY-P11434
    Adipophilin-derived peptide
    		Ligand
    Adipophilin-derived peptide is a peptide derived from Adipophilin. Adipophilin-derived peptide binds to HLA-A*0201. Adipophilin-derived peptide can be used in cancer research.
  • HY-P11437
    GFKQSSKAL
    		Ligand
    GFKQSSKAL is an e14a2 junctional sequence. GFKQSSKAL binds well to HLA-B8. GFKQSSKAL can be used in the research of chronic myeloid leukemia.
  • HY-126855S
    Cholic acid 7-sulfate-d4
    		Ligand
    Cholic acid 7-sulfate-d4 (7-Sulfocholic acid-d4) is the deuterium labeled Cholic acid 7-sulfate (HY-126855). Cholic acid 7-sulfate is a selective agonist targeting TGR5 (EC50=0.17 μM) and a ligand for MHC class I-related protein (MR1). As a gut-restricted TGR5 agonist, cholic acid 7-sulfate binds to TGR5 on enteroendocrine L cells, induces GLP-1 secretion, and improves glucose tolerance in a TGR5-dependent manner. Cholic acid 7-sulfate also acts as an endogenous ligand for MR1, promoting the survival of mucosal-associated invariant T cells MAIT and the expression of homeostatic gene signatures, affecting MAIT cell development and function. Cholic acid 7-sulfate is mainly used in the research of diabetes and MAIT cell-related immune regulation.