Orthopoxvirus
Orthopoxvirus is a genus of viruses in the family Poxviridae and subfamily Chordopoxvirinae. The orthopoxvirus genus consists of 12 viruses including variola virus, vaccinia virus (VV), cowpox viruses (CV), monkeypox virus, and camelpox virus.
There are not many drugs available for orthopoxvirus treatment. The only product currently available for treatment of complications of Orthopoxvirus infection is vaccinia immunoglobulin (VIG). In 2021, brincidofovir was approved by FDA for the treatment of smallpox and tecovirimat was approved by EMA for the treatment of monkeypox in 2022. A few active compounds including interferon and interferon inducers, and a variety of nucleosides or nucleotides have been reported to have activity against orthopoxvirus.
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Orthopoxvirus Related Products (140)
Related Products (140)
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Cidofovir-13C,15N2 disodium
0 ImagesCat. No.: HY-167911SSynonyms: GS 0504-13C,15N2 disodium; HPMPC-13C,15N2 disodium; (S)-HPMPC-13C,15N2 disodiumCidofovir-13C,15N2 disodium (GS 0504-13C,15N2 disodium) is the 13C- and 15N-labeled Cidofovir disodium (HY-167911). Cidofovir sodium is an acyclic monophosphate nucleotide analogue and CMV inhibitor with antiviral activity. Cidofovir sodium inhibits cytomegalovirus (CMV) replication by selectively inhibiting viral DNA polymerase. Cidofovir sodium induces apoptosis and can be used in studies of AIDS cytomegalovirus retinitis, herpes, and cancer. Cidofovir sodium also has anti-orthopoxvirus and anti-variola activities.
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Ancitabine hydrochloride (Standard)
0 ImagesSynonyms: Cyclocytidine hydrochloride (Standard); Cyclo-CMP hydrochloride (Standard); Cyclo-C (Standard)Ancitabine hydrochloride (Standard) is the analytical standard of Ancitabine hydrochloride. This product is intended for research and analytical applications. Ancitabine (Cyclocytidine) hydrochloride is a cytarabine derivative that inhibits viral replication. Ancitabine hydrochloride blocks vaccinia virus DNA replication, the progression of viral protein synthesis from early to late stages, and one-step growth of vaccinia virus. Ancitabine hydrochloride is applicable to research related to vaccinia virus infection, leukemia, human cytomegalovirus infection and colorectal cancer.
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Phosphonoacetic acid (Standard)
0 ImagesCat. No.: HY-128744RCAS No.: 4408-78-0Phosphonoacetic acid Standard is the analytical standard of Phosphonoacetic acid (HY-128744). This product is intended for research and analytical applications. Phosphonoacetic acid is a potent antiviral agent. Phosphonoacetic acid inhibits a variety of herpesviruses, orthopoxviruses, and retroviruses. Phosphonoacetic acid strongly inhibits viral and cellular DNA polymerase, reverse transcriptase, and terminal deoxynucleotidyl transferase activities in a non-competitive or uncompetitive manner by binding to the pyrophosphate site of the enzyme. Phosphonoacetic acid is useful for research related to lymphoid leukemia, herpesvirus infection, and vaccinia virus skin lesions.
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Cyclic HPMPC
0 ImagesCat. No.: HY-147014CAS No.: 127757-45-3Cyclic HPMPC is a potent antiviral agent. Cyclic HPMPC can increase arterial oxygen saturation levels in lethal vaccinia virus (IHD strain)-infected mice. Cyclic HPMPC improves the outcome of congenital guinea pig cytomegalovirus (GPCMV) infection and decreases viral replication in guinea pig model.
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Ribavirin-13C2
0 ImagesCat. No.: HY-W779404CAS No.: 1279035-36-7Synonyms: Ribasphere-13C2
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NIOCH 14
0 ImagesCat. No.: HY-147016CAS No.: 1268015-38-8NIOCH 14 is a antiviral agent and a pro-agent. NIOCH 14 has antiviral activity against orthopoxviruses. NIOCH 14 can significantly lower proportions of infected mice, and virus production levels in the lungs. NIOCH 14 can be used for researching anti-smallpox. NIOCH 14 shows anti-orthopoxvirus activity.
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Trifluridine-13C,15N2
0 ImagesCat. No.: HY-A0061SCAS No.: 2086328-10-9Synonyms: Trifluorothymidine-13C,15N2; 5-Trifluorothymidine-13C,15N2; TFT-13C,15N2Trifluridine-13C,15N2 is the 13C and 15N labeled Trifluridine. Trifluridine (Trifluorothymidine;5-Trifluorothymidine;TFT) is an irreversible thymidylate synthase inhibitor, and thereby suppresses DNA synthesis. Trifluridine is an antiviral agent for herpes simplex virus (HSV) infection. Trifluorothymidine also has anti-orthopoxvirus activity.
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Anti-E8L Antibody (NL_A151)
0 ImagesCat. No.: HY-P992077Anti-E8L Antibody (NL_A151) is a recombinant monoclonal antibody specific for the E8L protein of monkeypox virus.
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Ancitabine
0 ImagesCat. No.: HY-N0093ACAS No.: 31698-14-3Synonyms: Cyclocytidine; Cyclo-CMPAncitabine (Cyclocytidine) is a cytarabine derivative that inhibits viral replication. Ancitabine blocks vaccinia virus DNA replication, the progression of viral protein synthesis from early to late stages, and one-step growth of vaccinia virus. Ancitabine is applicable to research related to vaccinia virus infection, leukemia, human cytomegalovirus infection and colorectal cancer.
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Antiviral agent 74
0 ImagesCat. No.: HY-179638CAS No.: 3059641-72-1Antiviral agent 74 is an antiviral agent consisting of Cidofovir (HY-17438) prodrug and lipid chain. Antiviral agent 74 can inhibit the activity of viral DNA polymerase by transforming into Cidofovir.Antiviral agent 74 demonstrates potent antiviral activity against vacciniavirus (VACV) (EC50 = 0.156 μM) comparable to Brincidofovir (HY-14532). Antiviral agent 74 shows superior potency against monkeypox virus (MPXV) with an EC50 vales of 0.202 μM. Antiviral agent 74 can be used for the research of virus infection.
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Ribavirin (GMP)
0 ImagesCat. No.: HY-B0434GCAS No.: 36791-04-5Synonyms: Ribasphere (GMP); ICN-1229 (GMP)Ribavirin (GMP) is Ribavirin (HY-B0434) produced by using GMP guidelines. GMP small molecules work appropriately as an auxiliary reagent for cell therapy manufacture. Ribavirin (ICN-1229) is an antiviral agent against a broad spectrum of viruses including HCV, HIVl, and RSV. Ribavirin also has anti-orthopoxvirus and anti-variola activities.
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Thymidine-d2
0 ImagesCat. No.: HY-N1150S6CAS No.: 132376-92-2Synonyms: DThyd-d2; NSC 21548-d2
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Caprochlorone
0 ImagesCat. No.: HY-147013CAS No.: 13878-10-9Caprochlorone has antiviral activity against orthopoxvirus. Caprochlorone can inhibit cell penetration by virus, also delays release of newly formed virus from the cell. Caprochlorone decreases the titers of influenza virus in infected-mice lungs.
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Cytarabine-13C,15N2
0 ImagesCat. No.: HY-13605S1Synonyms: Cytosine β-D-arabinofuranoside-13C,15N2; Cytosine arabinoside-13C,15N2; Ara-C-13C,15N2Cytarabine-13C,15N2 (Cytosine β-D-arabinofuranoside-13C,15N2) is the 13C- and 15N-labeled Cytarabine (HY-13605). Cytarabine, a nucleoside analog, causes S phase cell cycle arrest and inhibits DNA polymerase. Cytarabine inhibits DNA synthesis with an IC50 of 16 nM. Cytarabine has antiviral effects against HSV. Cytarabine shows anti-orthopoxvirus activity.
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ZW-2038
0 ImagesCat. No.: HY-180883ZW-2038 is a potent and selective antiviral compound against vaccinia virus (VACV), monkeypox virus (MPXV), and cowpox virus (CPXV). ZW-2038 suppresses VACV DNA replication and downstream post-replicative gene expression, albeit without inhibiting MPXV resolvase (Mpr). ZW-2038 demonstrates potent antiviral activity in complex human and animal tissue models. ZW-2038 can be used for orthopoxviruses infection research.
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Mitoxantrone-d8 dihydrochloride
0 ImagesCat. No.: HY-13502ASSynonyms: Mitozantrone-d8dihydrochloride; NSC 301739-d8 dihydrochlorideMitoxantrone-d8 dihydrochloride is deuterated labeled Mitoxantrone dihydrochloride (HY-13502A). Mitoxantrone dihydrochloride is a potent topoisomerase II inhibitor. Mitoxantrone dihydrochloride also inhibits protein kinase C (PKC) activity with an IC50 of 8.5 μM. Mitoxantrone dihydrochloride induces apoptosis of B-CLL (B-chronic lymphocytic leukaemia) cells. Mitoxantrone dihydrochloride shows antitumor activity. Mitoxantrone dihydrochloride also has anti-orthopoxvirus activity with EC50s of 0.25 μM and and 0.8 μM for cowpox and monkeypox, respectively.
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Thymidine-13C-1
0 ImagesCat. No.: HY-N1150S3CAS No.: 240407-53-8Synonyms: DThyd-13C-1; NSC 21548-13C-1-
Anti-H3L Antibody (NAL_A185)
0 ImagesCat. No.: HY-P992081Anti-H3L Antibody (NAL_A185) is a neutralizing antibody targeting the H3L envelope protein of vaccinia virus (CV) belonging to the genus Orthopoxvirus. By binding to the H3L protein of intracellular mature virions, Anti-H3L Antibody (NAL_A185) blocks the binding of the virus to host cells, thereby neutralizing viral infectivity. Anti-H3L Antibody (NAL_A185) not only protects BALB/c mice from intranasal challenge with the lethal vaccinia virus WR strain, reducing weight loss and mortality, but also exhibits complement-dependent neutralizing activity against monkeypox virus. Among these properties, NAL_A185 is an immune target induced by the smallpox vaccine Dryvax; it elicits a robust recall antibody response and induces high-titer neutralizing antibodies in mice. Anti-H3L Antibody (NAL_A185) can be used for studies related to vaccinia virus infection, monkeypox and monkeypox disease.
