Ribavirin  (Synonyms: Ribasphere; ICN-1229)

Ribavirin (GMP) is Ribavirin (HY-B0434) produced by using GMP guidelines. GMP small molecules work appropriately as an auxiliary reagent for cell therapy manufacture. Ribavirin (ICN-1229) is an antiviral agent against a broad spectrum of viruses including HCV, HIVl, and RSV. Ribavirin also has anti-orthopoxvirus and anti-variola activities.

Treatment of LPS-stimulated microglia with 5, 10 and 20 μM Ribavirin GMP (ICN-1229) induces reduction of NO₂ levels for 43% (p<0.05), 53% (p<0.05) and 59% (p<0.05), respectively. Ribavirin GMP (ICN-1229) (10 mM) insignificantly decreases the cell surface area in non-stimulated culture, but significantly reduces cell surface area (by 32%, p<0.05) in LPS-stimulated microglia^[3].
Ribavirin GMP (ICN-1229) is active against DENV, with an EC₅₀ of 3 μM in A549 cells, and combination of CM-10-18 with Ribavirin GMP (ICN-1229) demonstrates a clear enhancement in the reduction of virus replication^[4].
Ribavirin (20 μM, 7 d) inhibits hepatitis C virus (HCV) replication in Functional hepatocyte-like cells which developed from hiPSC^[6].
Ribavirin (1, 10, 25 μg/ml, 72 h) attenuates ZIKV-induced cell apoptosis in hNPCs via modulation of apoptosis-regulatory genes and promotes survival signaling via the PI3K/AKT pathway^[7].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

ALT, AST activities and bilirubin levels are significantly loared by administration of JAT in combination with interferon and Ribavirin GMP (ICN-1229) (p<0.01). JAT, interferon or Ribavirin GMP alone with CCl₄, livers appear to exhibit some liver protection against CCl₄ as evident by the presence of normal hepatic cords, absence of necrosis and lesser fatty infiltration. Groups treated with JAT, Peg-interferon and Ribavirin GMP (ICN-1229) separately or in combination shows reduction in the expression of TGF- β and Bax. In the group treated by triple combination of interferon, Ribavirin GMP (ICN-1229), and JAT, the expression level of p53 is markedly reduced^[1].
Ribavirin GMP (ICN-1229) capsules (400 mg of Ribavirin GMP)-treated Wistar rats show a significant decrease in activin-A and significant increase in follistatin at the serum and liver levels. Ribavirin GMP (ICN-1229) has strong antiviral activity only when Ribavirin GMP is combined with either IFN-α or Peg-IFN-α^[2].
Ribavirin GMP (40 mg/kg, p.o.) significantly improves the antiviral efficacy of CM-10-18 in mice. Ribavirin GMP (ICN-1229) inhibits DENV virus infection in cultured cells, but it is ineffective in reducing viremia in monotherapy^[4].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

244.20

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36791-04-5

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Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Robert O Baker, et al. Potential antiviral therapeutics for smallpox, monkeypox and other orthopoxvirus infections. Antiviral Res. 2003 Jan;57(1-2):13-23.  [Content Brief]

  [2]. Abdel-Hamid NM, et al. Synergistic Effects of Jerusalem Artichoke in Combination with Pegylated Interferon Alfa-2a and Ribavirin Against Hepatic Fibrosis in Rats. Asian Pac J Cancer Prev. 2016;17(4):1979-85.  [Content Brief]

  [3]. Refaat B, et al. The effects of pegylated interferon-α and ribavirin on liver and serum concentrations of activin-A and follistatin in normal Wistar rat: a preliminary report. BMC Res Notes. 2015 Jun 26;8:265  [Content Brief]

  [4]. Savic D, et al. Ribavirin shows immunomodulatory effects on activated microglia. Immunopharmacol Immunotoxicol. 2014 Dec;36(6):433-41  [Content Brief]

  [5]. Chang J, et al. Combination of α-glucosidase inhibitor and ribavirin for the treatment of dengue virus infection in vitro and in vivo. Antiviral Res. 2011 Jan;89(1):26-34  [Content Brief]

  [6]. Sa-Ngiamsuntorn K, et al. A robust model of natural hepatitis C infection using hepatocyte-like cells derived from human induced pluripotent stem cells as a long-term host. Virol J. 2016 Apr 5;13:59.  [Content Brief]

  [7]. Kim JA, Seong RK, Kumar M, Shin OS. Favipiravir and Ribavirin Inhibit Replication of Asian and African Strains of Zika Virus in Different Cell Models. Viruses. 2018 Feb 9;10(2):72.  [Content Brief]