Transmembrane Glycoprotein
Transmembrane Glycoprotein
Transmembrane glycoproteins are important components of cell membranes and are characterized by oligosaccharide chains covalently linked to polypeptide chains. Glycosylation sites are mainly located in their extracellular regions, achieved by N-linked glycosylation (linked to asparagine residues) or O-linked glycosylation (linked to serine or threonine residues). Sugar chains not only provide structural stability to proteins but also confer functional specificity. Many transmembrane glycoproteins are receptors, such as G protein-coupled receptors (GPCRs) and receptor tyrosine kinases (RTKs). Most （clusters of differentiation）CD molecules are also transmembrane glycoproteins expressed on the surface of antigen-presenting cells[1][2].
References:
- [1]. L Franco, et al. The transmembrane glycoprotein CD38 is a catalytically active transporter responsible for generation and influx of the second messenger cyclic ADP-ribose across membranes. FASEB J. 1998 Nov;12(14):1507-20. [Content Brief]
- [2]. Kumi Oshima, et al. SHPS-1, a multifunctional transmembrane glycoprotein. FEBS Lett. 2002 May 22;519(1-3):1-7. [Content Brief]
All Product Categories
-
Transmembrane Glycoprotein Inhibitors
(233)
View all products
-
Transmembrane Glycoprotein Agonists
(8)
View all products
-
Transmembrane Glycoprotein Antagonists
(7)
View all products
-
Transmembrane Glycoprotein Activators
(10)
View all products
-
Transmembrane Glycoprotein Modulators
(5)
View all products
-
Transmembrane Glycoprotein Ligands
(16)
View all products
-
Transmembrane Glycoprotein Related Products (379)
Related Products (379)
-
HA-CD44 interaction inhibitor 3
0 ImagesCat. No.: HY-170955HA-CD44 interaction inhibitor 3 (compound 5d) is a Hyaluronic acid (HY-B0633A) (HA)-CD44 interaction inhibitor with antiproliferative activities. HA-CD44 interaction inhibitor 3 inhibits MDA-MB-231 (CD44++) cells and MCF-7 cells (CD44--) with EC50s of 4.24 μM and 14.74 μM, respectively. HA-CD44 interaction inhibitor 3 shows the potential for cancer research.
-
MEN1112
0 ImagesCat. No.: HY-P991665Synonyms: OBT357NF; OBT357MEN1112 (OBT357NF; OBT357) is a defucosylated humanized monoclonal antibody targeting Bst1/CD157, with an EC50 of 0.4 nM. MEN1112 binds to Bst1/CD157 on acute myeloid leukemia cells, triggers slow antigen internalization, induces antibody-dependent cell-mediated cytotoxicity, and mediates the lysis of acute myeloid leukemia cells and blasts. MEN1112 is applicable for research related to acute myeloid leukemia.
-
GPR17 agonist 2
0 ImagesCat. No.: HY-181738GPR17 agonist 2 (compound 10) is a human GPR17 agonist and selective P2Y receptor non-activator.GPR17 agonist 2 modulates intracellular cAMP levels through functional activation of its target receptor.GPR17 agonist 2 can be used for the research of multiple sclerosis, cerebral ischemia, traumatic brain injury, spinal cord injury.
-
Anti-TSPAN33 Antibody
0 ImagesCat. No.: HY-P992309
-
Anti-Mouse CD4 Antibody (YTS 177)
0 ImagesCat. No.: HY-P991824Anti-Mouse CD4 Antibody (YTS 177) reacts with the mouse CD4. Anti-Mouse CD4 Antibody (YTS 177) shows non-depleting but binding does induce rapid internalization of CD4 on both CD4+ Foxp3- T cells and Foxp3+ regulatory T cells. Recommend Isotype Controls: Rat IgG2a kappa, Isotype Control (HY-P990679).
-
VHPKQHR
0 ImagesCat. No.: HY-P11887CAS No.: 1174559-81-9VHPKQHR is a peptide-based delivery enhancer that binds to VCAM-1. VHPKQHR enables intracellular internalization of relevant nanomaterials and facilitates the targeted delivery of miRNA inhibitors to inflamed endothelial cells and endothelial cells activated by disturbed flow. When conjugated with magnetic mesoporous silica nanoparticles, VHPKQHR achieves targeted accumulation at atherosclerotic plaque sites. When displayed on the surface of polyelectrolyte complex micelles, VHPKQHR enhances the relevant effects of anti-miR-92a in Apoe-/- mice. When conjugated with ultrasmall superparamagnetic iron oxide nanoparticles, VHPKQHR forms a contrast agent for T1-weighted magnetic resonance imaging. VHPKQHR can be used in research related to atherosclerosis, stenosis and rheumatoid arthritis.
-
AM-928
0 ImagesCat. No.: HY-P992179AM-928 is a human monoclonal antibody targeting EpCAM/TROP1/CD326. AM-928 possesses potential anti-tumor activity.
-
BND-35
0 ImagesCat. No.: HY-P991307BND-35 is a human monoclonal antibody (mAb) targeting LILRB4/ILT3/CD85k. BND-35 blocks the interaction of ILT3 with APOE and fibronectin, enhances the pro-inflammatory activity of various myeloid cells, and reverses ILT3-mediated immunosuppression of T cells by various suppressive myeloid cells. BND-35 has anti-tumor activity in the hILT3 transgenic mouse tumor model.
-
HPN601
0 ImagesCat. No.: HY-P992370HPN601 is a monoclonal antibody targeting CD326/EPCAM, as well as a protease-activated EpCAM-targeted T cell engager. HPN601 binds to EPCAM, CD3e and albumin, and induces T cell-mediated tumor cell killing. HPN601 significantly reduces the release levels of IFN-γ, IL-2, IL-6, and IL-10. HPN601 can be used for relevant research on cancers such as breast cancer and gastric cancer.
-
CD36 Peptide P (93-110), Cys conjugated
0 ImagesCat. No.: HY-P10184CAS No.: 143257-75-4CD36 Peptide P (93-110), Cys conjugated is a Cys labelled CD36 Peptide, and can block binding of CD36 to immobilized thrombospondin and partially inhibited collagen-induced platelet aggregation.
-
KRN-330
0 ImagesCat. No.: HY-P990611
-
PLG-101
0 ImagesCat. No.: HY-P991895PLG-101 is a human anti-CD8 antibody. PLG-101 can be used in research on acute myocardial infarction .
-
Anti-Mouse ICOSL/CD275 (LALA-PG) Antibody (HK5.3)
0 ImagesCat. No.: HY-P990234Anti-Mouse ICOSL/CD275 (LALA-PG) Antibody (HK5.3) is a mouse-derived IgG2a κ type antibody inhibitor, targeting to mouse ICOSL/CD275. Anti-Mouse ICOSL/CD275 (LALA-PG) Antibody (HK5.3) is a chimeric antibody of the original HK5.3 antibody (HY-P990123). Anti-Mouse ICOSL/CD275 (LALA-PG) Antibody (HK5.3) contains the LALA-PG mutation region. Anti-Mouse ICOSL/CD275 (LALA-PG) Antibody (HK5.3) can neutralize ICOSL. Anti-Mouse ICOSL/CD275 (LALA-PG) Antibody (HK5.3) can be used for researches of inflammation and infection.
-
TPST2-IN-1
0 ImagesCat. No.: HY-179288TPST2-IN-1 is a potent and selective TPST2 inhibitor with an IC50 of 946 nM and a Ka of 19.4 μM. TPST2-IN-1 increases the phosphorylation of Stat1 and upregulates the IFNγ-responsive gene CXCL10 by inhibiting TPST2 activity.TPST2-IN-1 exhibits anti-tumor activity and enhances T cell-mediated antitumor immunity characterized by increased infiltration of effector CD8+ T cells. TPST2-IN-1 can be used for the research of cancer, such as colon cancer.
-
Anti-Mouse CD90 Antibody (HK2.1)
0 ImagesCat. No.: HY-P991808Anti-Mouse CD90 Antibody (HK2.1) reacts with the mouse CD90. Anti-Mouse CD90 Antibody (HK2.1) has been implicated in activation of T-cells. Recommend Isotype Controls: Rat IgG2c.
-
Anti-CD326 Antibody (17-1A)
0 ImagesCat. No.: HY-P992210
-
Anti-CHRDL-1 Antibody
0 ImagesCat. No.: HY-P992218
-
Thymopoietin i/ii (29-41) (bovine)
0 ImagesCat. No.: HY-P3967CAS No.: 56795-64-3Thymopoietin i/ii (29-41) (bovine) is a peptide corresponding to positions 29-41 of bovine thymopoietin II. Thymopoietin i/ii (29-41) (bovine) is a neuromuscular blocker.
-
NGM-707
0 ImagesCat. No.: HY-P991093NGM-707 is a humanized monoclonal antibody that blocks ILT2 and ILT4 receptors. NGM-707 has the potential for the study of advanced and metastatic solid tumors.
-
KHK2840
0 ImagesCat. No.: HY-P991918Synonyms: IgG2-AASKHK2840 is a potent CD40 agonist with a Kd value of 0.485 nM for hCD40. KHK2840 delivers agonistic signals in tumor-bearing hCD40 transgenic mice and human peripheral blood B cells. KHK2840 upregulates CD80, CD86, CD95 and IL-12p70 expression. KHK2840 enhances antitumor efficacy of anti-PD-1 antibody and Paclitaxel (HY-B0015). KHK2840 can be used for the research of cancer, such as colon cancer and melanoma.
