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Art. -Nr.: HY-184588

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AB13-08

AB13-08 is a selective dopamine receptor agonist with a K_i value of 53.9 nM for human D₃R. AB13-08 is applicable to the research of neurological disorders such as Parkinson's disease and schizophrenia.

Nur für Forschungszwecke. Wir verkaufen nicht an Patienten.

Formel: C₂₄H₃₁N₇O₂
Molecular Weight:449.55

Speicherung:

Please store the product under the recommended conditions in the Certificate of Analysis.

AB13-08 Chemical Structure

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Preis

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biologische Aktivität
- Beschreibung
- IC₅₀ & Target
- In Vitro
Chemical Information
Reinheit & Dokumentation
Verweise
Calculators
Help & FAQs
Classifications
Bioz

Biologische Aktivität

Beschreibung

IC₅₀ & Target^[1]

Human D₃ Receptor

53.9 nM (Ki)

Human D₂ Receptor

2690 nM (Ki)

Alle Dopamine Receptor Isoform-spezifische Produkte anzeigen :

In Vitro

AB13-08 (compound 4b) (90 min) binds to human D₃ receptors expressed in HEK293 cells with a K_i value of 53.9 nM, and exhibits 49.9-fold binding selectivity over human D₂ receptors (with a K_i value of 2690 nM)^[1].
AB13-08 acts as a full agonist on human D₃ receptors expressed in HEK293T cells, with a potency of 1.10 nM, and exhibits over 2800-fold potency selectivity over human D₂ receptors^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

Molecular Weight 449.55
Formel C₂₄H₃₁N₇O₂
SMILES

NC1=NC=C(C=C1)[C@H]2CN([C@H](CO2)C)CCCCNC(C3=CC(C)=CC=C3N4N=CC=N4)=O
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

Please store the product under the recommended conditions in the Certificate of Analysis.

Reinheit & Dokumentation

Handling Instructions (2659 KB)

Verweise

[1]. Arroyo-Urea S, et al. A Ligand-Triggered Receptor Conformation Enables the Design of Selective Agonists for the Dopamine 3 Receptor (D₃R) Using a Bitopic Strategy. JACS Au. 2026.

Calculators

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

Keywords

MOQ

Minimum order quantity

100 mg

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Biologische Aktivität
- Beschreibung
- IC₅₀ & Target
- In Vitro
Chemical Information
Reinheit & Dokumentation
Verweise

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AB13-08

Alle Dopamine Receptor Isoform-spezifische Produkte anzeigen