AB13-08
AB13-08 is a selective dopamine receptor agonist with a Ki value of 53.9 nM for human D3R. AB13-08 is applicable to the research of neurological disorders such as Parkinson's disease and schizophrenia.
For research use only. We do not sell to patients.
- Formula: C24H31N7O2
- Molecular Weight:449.55
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
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Biological Activity
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Chemical Information
- Protocols
- Purity & Documentation
- References
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Help & FAQs
All Dopamine Receptor Isoforms
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Biological Activity
Description
IC50 & Target
[1]|
Human D3 Receptor 53.9 nM (Ki) |
Human D2 Receptor 2690 nM (Ki) |
In Vitro
AB13-08 (compound 4b) (90 min) binds to human D3 receptors expressed in HEK293 cells with a Ki value of 53.9 nM, and exhibits 49.9-fold binding selectivity over human D2 receptors (with a Ki value of 2690 nM)[1].
AB13-08 acts as a full agonist on human D3 receptors expressed in HEK293T cells, with a potency of 1.10 nM, and exhibits over 2800-fold potency selectivity over human D2 receptors[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. Further protocols information, click here.
Chemical Information
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Molecular Weight 449.55
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Formula C24H31N7O2
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SMILES
NC1=NC=C(C=C1)[C@H]2CN([C@H](CO2)C)CCCCNC(C3=CC(C)=CC=C3N4N=CC=N4)=O
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Protocols
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Human pluripotent stem cell midbrain dopaminergic neuron differentiation
Human pluripotent stem cells are directed toward midbrain dopaminergic neurons by first inducing a neural floor-plate-like progenitor state, then patterning cells with ventralizing SHH signaling and midbrain/WNT-FGF cues, and finally maturing progenitors into neurons expressing dopaminergic markers such as TH, NURR1/NR4A2, PITX3, DAT/SLC6A3, VMAT2/SLC18A2, GIRK2/KCNJ6, FOXA2, LMX1A, and EN1. The main readouts are loss of pluripotency, acquisition of FOXA2+/LMX1A+ midbrain floor-plate progenitors, emergence of βIII-tubulin+/MAP2+ neurons, and production of TH+ dopaminergic neurons with molecular, dopamine-release, and electrophysiological features of midbrain dopaminergic identity.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
AB13-08 Related Classifications
HY-184588 Related Classifications
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