AChE-IN-122
AChE-IN-122 is an acetylcholinesterase (AChE) and monoamine oxidase B (MAO-B) inhibitor with IC50 values of 0.084 μM and 0.65 μM, respectively, and an IC50 of 0.667 μM against butyrylcholinesterase (BuChE). AChE-IN-122 can be used for research on Alzheimer's disease.
For research use only. We do not sell to patients.
- Formula: C25H18ClN5O2S
- Molecular Weight:487.96
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Protocols
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Description
IC50 & Target
[1]|
AChE 0.084 μM (IC50) |
BuChE 0.667 μM (IC50) |
MAO-B 0.65 μM (IC50) |
In Vitro
Chemical Information
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Molecular Weight 487.96
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Formula C25H18ClN5O2S
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SMILES
O=C1N(C2=CC=CC=C2)C(SCC(C3=C(C)N(C4=CC=CC=C4)N=N3)=O)=NC5=CC(Cl)=CC=C51
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Protocols
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Cell Cytotoxicity Assay
Cytotoxicity assays are usually based on the assessment of cell membrane damage, which can also be indirectly detected by measuring cell viability. Detection methods include MTT assay, CKK-8 assay, LDH assay and ATP assay, etc.
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Alzheimer’s Disease Modeling
Alzheimer’s Disease (AD) is a neurodegenerative disorder characterized by a progressive decline in cognitive functions and loss of specific types of neurons and synapses. Alzheimer's symptoms can be simulated in mice by injecting drugs (such as Aβ) or genetically modified.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
AChE-IN-122 Related Classifications
HY-189417 Related Classifications
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