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Cat. No.: HY-185833

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ADC Control Human IgG1-JSSW-001

ADC Control Human IgG1-JSSW-001 is the isotype control for ADC SYS6010 (HY-185832). SYS6010 is an antibody-drug conjugate (ADC) targeting epidermal growth factor receptor (EGFR), which is formed by conjugating the anti-EGFR humanized IgG1 monoclonal antibody Becotatug (HY-P990049) with the topoisomerase I inhibitor JS-1 (HY-178217) via a cleavable tetrapeptide linker. SYS6010 can be used in the research of advanced solid tumors such as non-small cell lung cancer.

For research use only. We do not sell to patients.

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

ADC Control Human IgG1-JSSW-001 Chemical Structure

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- In Vitro
Chemical Information
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Biological Activity

Description

All EGFR Isoforms :

All Topoisomerase Isoforms :

In Vitro

Isotype control ADCs match only the antibody backbone and lack antigen-binding capability; they are used to rule out non-specific toxicity and off-target effects associated with the antibody backbone, linker, or toxin.

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

SMILES

[ADC Control Human IgG1-JSSW-001]
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Lu, S., et al. (2025). Abstract CT008: First-in-human study of SYS6010, a novel EGFR targeting antibody drug conjugate (ADC) for patients with advanced solid tumors. Cancer Research, 85(8_Supplement_2), CT008-CT008.

[2]. Lu, S., et al. M., ... & Yang, Y. (2025). Abstract CT008: First-in-human study of SYS6010, a novel EGFR targeting antibody drug conjugate (ADC) for patients with advanced solid tumors. Cancer Research, 85(8_Supplement_2), CT008-CT008.

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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Biological Activity
- Description
- In Vitro
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References

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ADC Control Human IgG1-JSSW-001

All EGFR Isoforms

All Topoisomerase Isoforms

Biological Activity

Chemical Information

Purity & Documentation

References

Calculators

Help & FAQs

ADC Control Human IgG1-JSSW-001 Related Classifications

HY-185833 Related Classifications