SYS6010
SYS6010 is an antibody-drug conjugate (ADC) targeting epidermal growth factor receptor (EGFR), which is formed by conjugating the anti-EGFR humanized IgG1 monoclonal antibody Becotatug (HY-P990049) with the topoisomerase I inhibitor JS-1 (HY-178217) via a cleavable tetrapeptide linker. SYS6010 can be used in the research of advanced solid tumors such as non-small cell lung cancer.
For research use only. We do not sell to patients.
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
SYS6010 undergoes endocytosis, and its linker is cleaved by proteases to release the payload, thereby exerting anticancer effects after binding to EGFR on the surface of tumor cells[1][2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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SMILES
[SYS6010]
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
SYS6010 Related Classifications
HY-185832 Related Classifications
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- SYS6010
- SYS 6010
- SYS-6010
- Antibody-Drug Conjugates (ADCs)
- EGFR
- Topoisomerase
- EGFR wild-type nonsquamous non-small cell lung cancer
- advanced solid tumors
- EGFR-mutant nonsquamous non-small cell lung cancer
- anti-EGFR humanized IgG1 monoclonal antibody
- antibody drug conjugate
- advanced esophageal squamous cell carcinoma
- topoisomerase I inhibitor
- epidermal growth factor receptor
- non-small cell lung cancer
- Inhibitor
- inhibitor
- inhibit