Afatinib (Standard)
Based on 1 Customer Validation
Afatinib (Standard) is the analytical standard of Afatinib. This product is intended for research and analytical applications. Afatinib (BIBW 2992) is an orally active, potent and irreversible dual specificity inhibitor of ErbB family (EGFR and HER2), with IC50 values of 0.5 nM, 0.4 nM, 10 nM and 14 nM for EGFRwt, EGFRL858R, EGFRL858R/T790M and HER2, respectively. Afatinib can be used for the research of esophageal squamous cell carcinoma (ESCC), non-small cell lung cancer (NSCLC) and gastric cancer.
For research use only. We do not sell to patients.
- Purity : 97.64%
- CAS No.: 850140-72-6
- Formula: C24H25ClFN5O3
- Molecular Weight:485.94
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Product Information
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Chemical Information
- Purity & Documentation
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Help & FAQs
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HY-10261
AfatinibEGFR/HER2 Inhibitor -
HY-10261A
Afatinib dimaleateEGFR/HER2 Inhibitor -
HY-50896
ErlotinibEGFR Tyrosine Kinase Inhibitor -
HY-10260
VandetanibVEGFR2/3 Inhibitor -
HY-10261B
(E/Z)-AfatinibEGFR Inhibitor -
HY-50896R
Erlotinib (Standard)Reference Standard -
HY-10261AR
Afatinib dimaleate (Standard)EGFR/HER2 Inhibitor -
HY-13068
Golvatinib -
HY-11004
AZ 628Apoptosis Inducer -
HY-18750
ZorifertinibEGFR Inhibitor -
HY-101429
RG13022Tyrosine Kinase Inhibitor -
HY-13427
Allitinib tosylateIrreversible EGFR/ErbB2 Inhibitor
Product Information
Information
Application
The compound is the grade of analytical standard, which is the reference standard supplied assay. It is commonly used in qualitative, quantitative and methodological research experiments in HPLC, GC and MS.
Chemical Information
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CAS No. 850140-72-6
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Appearance Solid
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Molecular Weight 485.94
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Formula C24H25ClFN5O3
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Color White to off-white
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SMILES
O=C(NC1=C(C=C2C(C(NC3=CC(Cl)=C(C=C3)F)=NC=N2)=C1)O[C@H]4CCOC4)/C=C/CN(C)C
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Synonyms
BIBW 2992 (Standard)
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
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SDS (557 KB)
- English - EN (557 KB)
- Français - FR (557 KB)
- Deutsch - DE (557 KB)
- Norwegian - NO (557 KB)
- Español - ES (557 KB)
- Swedish - SV (557 KB)
- Italian - IT (557 KB)
- Korean - KR (557 KB)
- Portuguese - PT (557 KB)
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Handling Instructions (2659 KB)
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Afatinib (Standard) Related Classifications
HY-10261R Related Classifications
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Keywords
- Afatinib (Standard)
- 850140-72-6
- BIBW 2992 (Standard)
- Reference Standards
- EGFR
- Autophagy
- Apoptosis
- c-Met/HGFR
- Akt
- p38 MAPK
- Epidermal growth factor receptor
- ErbB-1
- HER1
- PKB
- Protein kinase B
- NSCLC
- H1666
- H3255
- NCI-H1975
- NIH-3T3 cells
- A431
- ESCC
- HER2
- AKT
- HKESC-1
- HKESC-2
- SLMT-1
- EC-1
- anticancer
- orally active
- lung cancer
- Inhibitor
- inhibitor
- inhibit