10A1P16
10A1P16 is an ionizable phospholipid composed of a tertiary amine, a phosphate group and three hydrophobic tails. As a spleen-selective RNA delivery vector, 10A1P16 successfully transfects approximately 30% of splenic macrophages and 6% of splenic B cells in vivo. 10A1P16 can be used to prepare spleen-selective 10A1P16-MDOA lipid nanoparticles, which effectively mediate mRNA delivery and gene editing in mouse models. This delivery system retains potent spleen-targeted mRNA delivery efficacy and can be applied to ovarian cancer research.
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- CAS. Nr.: 2760467-77-2
- Formel: C38H80NO4P
- Molecular Weight:646.02
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Speicherung:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biologische Aktivität
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Chemical Information
- Reinheit & Dokumentation
- Verweise
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Help & FAQs
Biologische Aktivität
Beschreibung
In Vitro
10A1P16 iPLNPs (50 ng mRNA per well; 24 h) mediate high mRNA delivery efficacy in IGROV-1 ovarian cancer cells as part of a single zwitterion, three-tailed iPhos subgroup with a ~60% in vitro hit rate[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
In Vivo
10A1P16-MDOA iPLNs (i.v.; single dose) enable spleen-selective gene editing in Ai9 reporter mice, transfecting ~30% of splenic macrophages and 6% of splenic B cells[1].
The 10A1P16-based iPLNP formulation achieves spleen-selective RNA delivery in wild-type mice, transfecting 30% of splenic macrophages and 6% of splenic B cells[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:C57BL/6 Mice (female, 6-8 weeks old)[1]
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Dosage:0.1 mg/kg luciferase mRNA; 0.25 mg/kg luciferase mRNA
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Administration:i.v.; single dose
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Result:Mediated selective luciferase mRNA expression in the spleen.
Chemical Information
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CAS. Nr. 2760467-77-2
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Molecular Weight 646.02
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Formel C38H80NO4P
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SMILES
O=P(OCCCCCCCCCCCCCCCC)([O-])OCC[NH+](CCCCCCCCCC)CCCCCCCCCC
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
Please store the product under the recommended conditions in the Certificate of Analysis.
Reinheit & Dokumentation
Verweise
[1]. Liu S, et al. Membrane-destabilizing ionizable phospholipids for organ-selective mRNA delivery and CRISPR–Cas gene editing[J]. Nature materials, 2021, 20(5): 701-710. [Content Brief]
[2]. Song D, et al. Tuning lipid nanoparticles for RNA delivery to extrahepatic organs[J]. Advanced Materials, 2024, 36(44): 2401445. [Content Brief]
[3]. Fu L, et al. ‘Passive’nanoparticles for organ-selective systemic delivery: design, mechanism and perspective[J]. Chemical Society Reviews, 2023, 52(21): 7579-7601. [Content Brief]
Calculators
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
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