3′-Oxolutein
3′-Oxolutein, a metabolite of dietary lutein, is an anti-inflammatory agent and antioxidant, 3′-Oxolutein mitigates the effects of glutamate-induced ROS production and proinflammatory cytokine secretions in SH-SY5Y cells. 3'-Oxolutein reduces glutamate-induced iron content and increases thiol levels. 3′-Oxolutein can be used for the study of inflammation.
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- CAS. Nr.: 23984-55-6
- Formel: C40H54O2
- Molecular Weight:566.86
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Speicherung:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biologische Aktivität
Beschreibung
In Vitro
3'-Oxolutein (10 ng/μL, 10-30 min) significantly reduces glutamate-induced ROS production in SH-SY5Y cells[1].
3'-Oxolutein (10 ng/μL, 24-72 h) increases small molecule antioxidants level at 48 h but fails to modify TAC levels in glutamate-treated SH-SY5Y cells[1].
3'-Oxolutein (10 ng/μL, 24-72 h) alone does not alter SOD activity and cannot inhibit the decrease in SOD in glutamate-treated SH-SY5Y cells[1].
3'-Oxolutein (10 ng/μL, 24-72 h) reduces glutamate-induced iron content in SH-SY5Y cells[1].
3'-Oxolutein (10 ng/μL, 24-72 h) reduces glutamate-induced relative mRNA expressions of ALOX5, ALOX15, and ACSL4 genes in SH-SY5Y cells[1].
3'-Oxolutein (10 ng/μL, 24-72 h) does not induce alteration in IL-6 secretion in SH-SY5Y cells but reduces glutamate-induced IL-8 secretions and diminishes TNFα levels[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:SH-SY5Y cells
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Concentration:10 ng/μL
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Incubation Time:24, 48, 72 h
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Result:Reduced relative mRNA expressions of ALOX5, ALOX15, and ACSL4 genes in OG1 and OG5 treatments compared to glutamate-treated SH-SY5Y cells.
Chemical Information
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CAS. Nr. 23984-55-6
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Molecular Weight 566.86
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Formel C40H54O2
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SMILES
CC1(C)C(/C=C/C(C)=C/C=C/C(C)=C/C=C/C=C(C)/C=C/C=C(C)/C=C/[C@@H]2C(C)(CC(C=C2C)=O)C)=C(C)C[C@@H](O)C1
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Synonyms
3'-Dehydrolutein; Philosamiaxanthin
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Structure Classification
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Initial Source
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
Please store the product under the recommended conditions in the Certificate of Analysis.
Reinheit & Dokumentation
Verweise
Calculators
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
3′-Oxolutein Related Classifications
HY-W743769 Related Classifications
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