8-Hydroxyguanine
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8-Hydroxyguanine is a DNA damage product under oxidative stress, which is formed when hydroxyl radicals attack guanine in DNA. 8-Hydroxyguanine induces mutagenesis and leads to a transversion from G to T. 8-Hydroxyguanine is a marker of DNA oxidative damage.
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- Reinheit: 90.05%
- CAS. Nr.: 5614-64-2
- Formel: C5H5N5O2
- Molecular Weight:167.13
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Speicherung:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
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Biologische Aktivität
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Chemical Information
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Lösungsmittel & Löslichkeit
- Reinheit & Dokumentation
- Verweise
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Help & FAQs
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Biologische Aktivität
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Human Endogenous Metabolite |
The most common product of ROS-induced base damage is 8-Hydroxyguanine. Failure to promptly remove 8-Hydroxyguanine often causes mutations during DNA replication. 8-Hydroxyguanine is cleared from cells by the 8-oxoG DNA glycosylase 1 (OGG1)-mediated oxidative damage base excision repair pathway so as to prevent cells from suffering dysfunction due to oxidative stress[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS. Nr. 5614-64-2
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Appearance Solid
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Molecular Weight 167.13
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Formel C5H5N5O2
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Color Light brown to khaki
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SMILES
O=C1NC(N)=NC2=C1NC(N2)=O
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Synonyms
8-Oxoguanine; 8-oxo-Gua
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Structure Classification
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Lösungsmittel & Löslichkeit
1M NaOH : 25 mg/mL (149.58 mM; ultrasonic and adjust pH to 12 with 1M NaOH)
H2O : 4.72 mg/mL (28.24 mM; ultrasonic and warming and adjust pH to 11 with NaOH and heat to 60°C)
Ethanol : < 1 mg/mL (insoluble)
DMSO : < 1 mg/mL (insoluble or slightly soluble)
* 8-Hydroxyguanine is usually formulated as a suspension.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
Reinheit & Dokumentation
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Data Sheet (272 KB)
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SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
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Handling Instructions (2659 KB)
Verweise
[1]. Spencer JP, et al., DNA strand breakage and base modification induced by hydrogen peroxide treatment of human respiratory tract epithelial cells. FEBS Lett. 1995 Oct 30;374(2):233-6. [Content Brief]
[2]. Zhang W, et al. Effect of 8-Hydroxyguanine DNA Glycosylase 1 on the Function of Immune Cells. Antioxidants (Basel). 2023 Jun 19;12(6):1300. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| H2O / 1M NaOH | 1 mM | 5.9834 mL | 29.9168 mL | 59.8337 mL | 149.5842 mL |
| 5 mM | 1.1967 mL | 5.9834 mL | 11.9667 mL | 29.9168 mL | |
| 10 mM | 0.5983 mL | 2.9917 mL | 5.9834 mL | 14.9584 mL | |
| 15 mM | 0.3989 mL | 1.9945 mL | 3.9889 mL | 9.9723 mL | |
| 20 mM | 0.2992 mL | 1.4958 mL | 2.9917 mL | 7.4792 mL | |
| 25 mM | 0.2393 mL | 1.1967 mL | 2.3933 mL | 5.9834 mL | |
| 1M NaOH | 30 mM | 0.1994 mL | 0.9972 mL | 1.9945 mL | 4.9861 mL |
| 40 mM | 0.1496 mL | 0.7479 mL | 1.4958 mL | 3.7396 mL | |
| 50 mM | 0.1197 mL | 0.5983 mL | 1.1967 mL | 2.9917 mL | |
| 60 mM | 0.0997 mL | 0.4986 mL | 0.9972 mL | 2.4931 mL | |
| 80 mM | 0.0748 mL | 0.3740 mL | 0.7479 mL | 1.8698 mL | |
| 100 mM | 0.0598 mL | 0.2992 mL | 0.5983 mL | 1.4958 mL |
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
8-Hydroxyguanine Related Classifications
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