Art. -Nr.: HY-N2070

Acevaltrate

4 Cited Publications

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Based on 4 publication(s) in Google Scholar

Acevaltrate inhibits the Na⁺/K⁺-ATPase activity in the rat kidney and brain hemispheres with IC₅₀s of 22.8 μM and 42.3 μM, respectively.

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Reinheit: 99.71%
CAS. Nr.: 25161-41-5
Formel: C₂₄H₃₂O₁₀
Molecular Weight:480.50

Speicherung:

4°C, protect from light

* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Acevaltrate Chemical Structure

CAS. Nr.: 25161-41-5

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Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biologische Aktivität
- Beschreibung
- IC₅₀ & Target
- Cellular Effect
- In Vitro
Chemical Information
Publications (4)
Lösungsmittel & Löslichkeit
- In Vitro
- In Vivo
Reinheit & Dokumentation
Verweise
Help & FAQs
Classifications
Bioz

Biologische Aktivität

Beschreibung

Acevaltrate inhibits the Na⁺/K⁺-ATPase activity in the rat kidney and brain hemispheres with IC₅₀s of 22.8 μM and 42.3 μM, respectively^[1].

IC₅₀ & Target

IC50: 22.8±1.1 μM (Na⁺/K⁺-ATPase, in rat kidney), 42.3±1.0 μM (Na⁺/K⁺-ATPase, in rat brain hemispheres)^[1]

Cellular Effect

Cell Line	Type	Value	Description	References
A549	IC₅₀	2.9 μM Compound: 22	Cytotoxicity against human A549 cells after 24 hrs by MTT assay Cytotoxicity against human A549 cells after 24 hrs by MTT assay	[PMID: 19245261]
Bel-7402	IC₅₀	1.7 μM Compound: 22	Cytotoxicity against human Bel7402 cells after 24 hrs by MTT assay Cytotoxicity against human Bel7402 cells after 24 hrs by MTT assay	[PMID: 19245261]
HCT-8	IC₅₀	1 μM Compound: 22	Cytotoxicity against human HCT8 cells after 24 hrs by MTT assay Cytotoxicity against human HCT8 cells after 24 hrs by MTT assay	[PMID: 19245261]
PC-3M	IC₅₀	1.4 μM Compound: 22	Cytotoxicity against human PC3M cells after 24 hrs by MTT assay Cytotoxicity against human PC3M cells after 24 hrs by MTT assay	[PMID: 19245261]

In Vitro

Acevaltrate differentiallys inhibit the activity of rat P-type ATPases in vitro. 60.7±7.3% inhibition of the rat H⁺/K⁺-ATPase is achieved at 100 μM^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS. Nr. 25161-41-5
Appearance Solid
Molecular Weight 480.50
Formel C₂₄H₃₂O₁₀
Color White to off-white
SMILES

O=C(CC(C)(C)OC(C)=O)O[C@@H]1[C@]2(CO2)[C@]([C@@H]3OC(CC(C)C)=O)([H])C(C(COC(C)=O)=CO3)=C1
Structure Classification
- Terpenoids
- Iridoids
Initial Source
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

4°C, protect from light

* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Publications (4)

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Journal Impact Factor

Acta Pharmacol Sin

Bardoxolone displays potent activity against triple negative breast cancer by inhibiting the TRIP13/STAT3 circuit. [Abstract]

2025 Jun;46(6):1733-1741. PMID: 39939802
Acta Pharmacol Sin

Suppression of the USP10/CCND1 axis induces glioblastoma cell apoptosis. [Abstract]

2021 Aug;42(8):1338-1346. PMID: 33184448
Molecules

Identification of Marrubiin as a Cathepsin C Inhibitor for Treating Rheumatoid Arthritis. [Abstract]

2025 Oct 23;30(21):4170. PMID: 41226133
Patent

US20240216411A1.

Lösungsmittel & Löslichkeit

In Vitro:

DMSO : 100 mg/mL (208.12 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

View the Complete Stock Solution Preparation Table

Preparing Stock Solutions

View the Complete Stock Solution Preparation Table

Concentration Solvent Mass

1 mg

5 mg

10 mg

Concentration

Solvent

Mass

1 mM

2.0812 mL

10.4058 mL

20.8117 mL

5 mM

0.4162 mL

2.0812 mL

4.1623 mL

10 mM

0.2081 mL

1.0406 mL

2.0812 mL

Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.

Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

Stock Solution Working Solution

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: 10% DMSO 90% Corn Oil

Solubility: ≥ 2.08 mg/mL (4.33 mM); Clear solution

This protocol yields a clear solution of ≥ 2.08 mg/mL (saturation unknown). If the continuous dosing period exceeds half a month, please choose this protocol carefully.

Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (20.8 mg/mL) to 900 μL Corn oil, and mix evenly.

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage Dosage
mg/kg
Animal Weight (Per Animal) Animal Weight (Per Animal)
g
Dosing Volume (Per Animal) Dosing Volume (Per Animal)
μL
Number of Animals Number of Animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Please enter your animal formula composition:

%
DMSO +

Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
%
+
+
%
Tween-80 + +
%
Saline +

The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).

Working solution concentration: 0.22 mg/mL

Reinheit & Dokumentation

Select Batch:

Reinheit: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (275 KB)
SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

Verweise

[1]. Bettero GM, et al. In vitro effect of valepotriates isolated from Valeriana glechomifolia on rat P-type ATPases. Planta Med. 2011 Oct;77(15):1702-6. [Content Brief]

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg
DMSO	1 mM	2.0812 mL	10.4058 mL	20.8117 mL	52.0291 mL
	5 mM	0.4162 mL	2.0812 mL	4.1623 mL	10.4058 mL
	10 mM	0.2081 mL	1.0406 mL	2.0812 mL	5.2029 mL
	15 mM	0.1387 mL	0.6937 mL	1.3874 mL	3.4686 mL
	20 mM	0.1041 mL	0.5203 mL	1.0406 mL	2.6015 mL
	25 mM	0.0832 mL	0.4162 mL	0.8325 mL	2.0812 mL
	30 mM	0.0694 mL	0.3469 mL	0.6937 mL	1.7343 mL
	40 mM	0.0520 mL	0.2601 mL	0.5203 mL	1.3007 mL
	50 mM	0.0416 mL	0.2081 mL	0.4162 mL	1.0406 mL
	60 mM	0.0347 mL	0.1734 mL	0.3469 mL	0.8672 mL
	80 mM	0.0260 mL	0.1301 mL	0.2601 mL	0.6504 mL
	100 mM	0.0208 mL	0.1041 mL	0.2081 mL	0.5203 mL

Keywords

Acevaltrate

4 Cited Publications

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Acevaltrate

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Traditional Chinese Medicine Active Compound Library

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Targeted Diversity Library

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Natural Product and Natural Product-Like Compound Library

Membrane Transporter/Ion Channel Compound Library

Natural Product Library

Publications Citing Use of MedChemExpress (MCE) Acevaltrate

Biologische Aktivität

Chemical Information

Publications (4)

Lösungsmittel & Löslichkeit

Reinheit & Dokumentation

Verweise

Help & FAQs

Complete Stock Solution Preparation Table

Acevaltrate

Covalent Screening Library

Terpenoids Library

Traditional Chinese Medicine Active Compound Library

Food-Sourced Compound Library

Targeted Diversity Library

Plant-Sourced Natural Product Library

Human Metabolite Library

Membrane Protein-targeted Compound Library

Cysteine Targeted Covalent Library

Bioactive Compound Library Max

MCE Bioactive Compound Library

Covalent Screening Library Plus

Natural Product Library Plus

Bioactive Compound Library

Miao Ethnicity Medicine Compound Library

RO5 Drug-like Natural Product Library

High-Throughput Bioactive Compound Library

High-Throughput Natural Product Library

Mass Spectrometry Human Metabolite Library

Mongolian Medicine Compound Library

Mass Spectrometry Natural Product Library

Natural Product and Natural Product-Like Compound Library

Membrane Transporter/Ion Channel Compound Library

Natural Product Library

Publications Citing Use of MedChemExpress (MCE) Acevaltrate

Biologische Aktivität

Chemical Information

Publications (4)

Lösungsmittel & Löslichkeit

Reinheit & Dokumentation

Verweise

Help & FAQs

Complete Stock Solution Preparation Table

Acevaltrate Related Classifications

HY-N2070 Related Classifications