Art. -Nr.: HY-Y0304

Dibutyl phthalate

11 Cited Publications

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Dibutyl phthalate is a commonly used plasticizer commonly found in some food packaging materials, personal care products, and the coating of oral medications. May cause toxicity and adverse neurobehavioral effects.

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Reinheit: 99.85%
CAS. Nr.: 84-74-2
Formel: C₁₆H₂₂O₄
Molecular Weight:278.34

Speicherung:

Pure form -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month

Dibutyl phthalate Chemical Structure

CAS. Nr.: 84-74-2

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Biologische Aktivität
- Beschreibung
- Cellular Effect
- In Vitro
- In Vivo
Chemical Information
Publications (11)
Lösungsmittel & Löslichkeit
- In Vitro
- In Vivo
Reinheit & Dokumentation
Verweise
Help & FAQs
Classifications
Bioz

Biologische Aktivität

Beschreibung

Dibutyl phthalate is a commonly used plasticizer commonly found in some food packaging materials, personal care products, and the coating of oral medications^[1]. May cause toxicity and adverse neurobehavioral effects^[2]^[3].

Cellular Effect

Cell Line	Type	Value	Description	References
B16-F10	IC₅₀	0.23 mM Compound: 1	Inhibition of cathepsin B in mouse B16F10 cells Inhibition of cathepsin B in mouse B16F10 cells	[PMID: 18289850]

In Vitro

Dibutyl phthalate (0.001 μg/mL-1000 μg/mL) is detrimental to follicle growth and viability and results in significant dysregulation of cell cycle and apoptosis gene expression in a dose-specific manner. But MBP does not play a role in Dibutyl phthalate toxicity in follicles exposed in vitro^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Dibutyl phthalate (200, 400, or 600 mg/kg/day) induces decrease mice weight, impairment of spermatogenesis, reduces serum follicle stimulating hormone and testosterone level, alters testicular LDH, increases LPO, and decreases the levels of enzymatic antioxidants with histopathological anomalies^[2].

Dibutyl phthalate (6.25, 12.5, 25, 50, 100 and 200 mg/kg) could cause some neurobehavioral adverse effects in mice^[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS. Nr. 84-74-2
Appearance Liquid (Density: 1.043 g/cm³ )
Molecular Weight 278.34
Formel C₁₆H₂₂O₄
Color Colorless to light yellow
SMILES

O=C(C1=CC=CC=C1C(OCCCC)=O)OCCCC
Structure Classification
- Others
Initial Source
- Plants
- other families
Versand

Room temperature in continental US; may vary elsewhere.

Speicherung

Pure form	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Publications (11)

All In Vivo Efficacy StudyIHCBio/Physico-chemical Assay

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Journal Impact Factor

Nat Commun

Gut symbiont-derived sphingosine modulates vector competence in Aedes mosquitoes. [Abstract]

2024 Sep 19;15(1):8221. PMID: 39300135
J Adv Res

Natural, safety immunomodulatory derivatives of lactobacillus biofilms promote diabetic wound healing by metabolically regulating macrophage phenotype and alleviating local inflammation. [Abstract]

2025 Apr 3:S2090-1232(25)00220-6. PMID: 40187726
Environ Pollut

Dibutyl phthalate exposure-induced AhR activation drives ferroptosis and HMGB1/TLR4-mediated inflammatory liver injury via NRF2-HO-1 signaling. [Abstract]

2026 Jun 1:398:128010. PMID: 41887355
Environ Pollut

Novel insights into DBP-induced zebrafish liver inflammatory damage: Ferroptosis activating the HMGB1-TLR4-NF-κB signaling pathway. [Abstract]

2025 May 7:126395. PMID: 40345373
J Agric Food Chem

Analysis of the Antagonistic Effect of Dibutyl Phthalate on Magnaporthe oryzae through Bioassay and Omics Data. [Abstract]

2025 Jul 30;73(30):18804-18821. PMID: 40674033
Ecotoxicol Environ Saf

The role of Lactobacillus in dibutyl phthalate-induced gut and liver injury: Probiotic intervention and multi-omics evidence. [Abstract]

2026 Apr 1:314:120051. PMID: 41895142

Dibutyl phthalate purchased from MedChemExpress. Usage Cited in: Ecotoxicol Environ Saf. 2026 Apr 1:314:120051. [Abstract]

Mice in the Dibutyl phthalate (DBP, 50-200 mg/kg, 28 days)-treated group displayed lethargy, disheveled coats, and sluggish responses. Adverse reactions intensified with increasing DBP doses, though no mouse deaths occurred during the trial.

Dibutyl phthalate purchased from MedChemExpress. Usage Cited in: Ecotoxicol Environ Saf. 2026 Apr 1:314:120051. [Abstract]

With increasing Dibutyl phthalate (DBP, 50-200 mg/kg, 28 days) doses, mouse body weight gradually decreased while liver weight and organ coefficient progressively increased.

Dibutyl phthalate purchased from MedChemExpress. Usage Cited in: Ecotoxicol Environ Saf. 2026 Apr 1:314:120051. [Abstract]

Histopathological analysis revealed that Dibutyl phthalate (DBP, 50-200 mg/kg, 28 days) exposure caused severe liver damage characterized by disrupted hepatic cord arrangement, hepatocyte swelling, and the appearance of lipid droplets.

Dibutyl phthalate purchased from MedChemExpress. Usage Cited in: Ecotoxicol Environ Saf. 2026 Apr 1:314:120051. [Abstract]

Dibutyl phthalate (DBP) exposure induced differential expression in 454 genes, with 240 up-regulated and 214 down-regulated genes identified.

Dibutyl phthalate purchased from MedChemExpress. Usage Cited in: Ecotoxicol Environ Saf. 2026 Apr 1:314:120051. [Abstract]

Dibutyl phthalate (DBP, 50-200 mg/kg, 28 days) exposure induced severe damage to the intestinal physical barrier. Histological examination showed shortened and disordered ileal villi.
Ecotoxicol Environ Saf

Subacute dibutyl phthalate exposure impairs hepatic T cells and facilitates hepatitis B progression in mouse liver. [Abstract]

2025 May 28:299:118398. PMID: 40440982
iScience

Mechanistic evidence for dibutyl phthalate as an environmental trigger for inflammatory bowel disease. [Abstract]

2026 Jan 5;29(2):114619. PMID: 41630903
Food Chem Toxicol

Integrative network toxicology reveals lipoprotein lipase as a key mediator of dibutyl phthalate-associated head and neck squamous cell carcinoma. [Abstract]

2026 Jul:213:116091. PMID: 41935815
Food Chem Toxicol

Integrated network toxicology and transcriptomics analysis reveals the pathogenic mechanisms in DBP/MBP-induced MASLD/MASH. [Abstract]

2026 Jun:212:116039. PMID: 41771476
Sci Total Environ

Dibutyl phthalate induces liver fibrosis via p38MAPK/NF-κB/NLRP3-mediated pyroptosis. [Abstract]

2023 Nov 1:897:165500. PMID: 37442457

Lösungsmittel & Löslichkeit

In Vitro:

DMSO : 100 mg/mL (359.27 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Ethanol : ≥ 50 mg/mL (179.64 mM)

* "≥" means soluble, but saturation unknown.

View the Complete Stock Solution Preparation Table

Preparing Stock Solutions

View the Complete Stock Solution Preparation Table

Concentration Solvent Mass

1 mg

5 mg

10 mg

Concentration

Solvent

Mass

1 mM

3.5927 mL

17.9636 mL

35.9273 mL

5 mM

0.7185 mL

3.5927 mL

7.1855 mL

10 mM

0.3593 mL

1.7964 mL

3.5927 mL

Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.

Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

Stock Solution Working Solution

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline