Art. -Nr.: HY-16321

Micafungin sodium

Name: Micafungin sodium
Brand: MedChemExpress
SKU: HY-16321
Price: 79.00 USD
Availability: InStock
Rating: 5 (22 reviews)

(Synonyms: FK 463 sodium)

22 Cited Publications

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Based on 22 publication(s) in Google Scholar

Micafungin sodium (FK 463 sodium) is an antifungal agent which inhibits 1, 3-beta-D-glucan synthesis.

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Reinheit : 98.91%
CAS. Nr.: 208538-73-2
Formel: C₅₆H₇₀N₉NaO₂₃S
Molecular Weight:1292.26

Speicherung:

4°C, sealed storage, away from moisture and light

* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

Micafungin sodium Chemical Structure

CAS. Nr.: 208538-73-2

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Biologische Aktivität
- Beschreibung
- In Vitro
- In Vivo
- Clinical Trial
Chemical Information
Publications (22)
Lösungsmittel & Löslichkeit
- In Vitro
Reinheit & Dokumentation
Verweise
Help & FAQs
Classifications
Bioz

Biologische Aktivität

Beschreibung

Micafungin sodium (FK 463 sodium) is an antifungal agent which inhibits 1, 3-beta-D-glucan synthesis.

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In Vitro

Micafungin (10 mg/mL) phenotypicly decreases the formation of biofilm in most of the isolates. For all the genes tested, the levels of mRNA transcription are also decreased significantly in micafungin-treated samples cf. their untreated counterparts^[1]. The combination of micafungin and KB425796-C is fungicidal and markedly reduces the number of CFU, in contrast to the fungistatic effects (no reduction in CFU) observed at all examined time points when each drug is used alone^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. .

In Vivo

Micafungin (1 mg/kg) significantly prolongs survival compared with mice administered saline. Animals given a combination of micafungin (0.1 mg/kg) and KB425796-C (32 mg/kg) show a trend towards prolonged survival in comparison with those treated with micafungin (0.1 mg/kg) alone. In the livers of micafungin-treated mice, the number of CFUs decreases, although the clearance effect is less than that found in the kidneys. Combination treatment with micafungin and KB425796-C results in a significant decrease in the number of CFUs compared with the treatment with micafungin alone at all examined doses. The clearance effect associated with KB425796-C in combination with micafungin is greater than that observed in AMPH-treated animals^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Clinical Trial

NCT Number	Sponsor	Condition	Start Date	Phase A549
NCT01329991	Plexxikon\|		2011-05	PHASE1

Chemical Information

CAS. Nr. 208538-73-2
Appearance Solid
Molecular Weight 1292.26
Formel C₅₆H₇₀N₉NaO₂₃S
Color White to off-white
SMILES

O=S(OC1=CC([C@H](O)[C@@H](O)C(NC(C2N(C(C(NC([C@]([H])(C[C@@H](O)[C@@H](O)NC(C3N(C(C([C@H](O)CC(N)=O)N4)=O)C[C@H](C)[C@@H]3O)=O)NC(C5=CC=C(C6=NOC(C7=CC=C(OCCCCC)C=C7)=C6)C=C5)=O)=O)[C@H](O)C)=O)C[C@H](O)C2)=O)C4=O)=CC=C1O)(O[Na])=O
Synonyms

FK 463 sodium
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

4°C, sealed storage, away from moisture and light

* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

Publications (22)

All Microbiological Assay

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Journal Impact Factor

Exp Mol Med

UBE2M as a bridge spanning neddylation and cell cycle regulation in colorectal adenocarcinoma. [Abstract]

2026 Mar;58(2):501-518. PMID: 41680469
Adv Sci (Weinh)

Calcineurin-Dependent Stress Adaptation Enables Caspofungin Heteroresistance Leading to Stable Resistance in Candida Glabrata. [Abstract]

2026 Jun 28:e76369. PMID: 42365577
NPJ Antimicrob Resist

Hotspot gene conversion between FKS1 and FKS2 in echinocandin resistant Candida glabrata serial isolates. [Abstract]

2025 Apr 17;3(1):31. PMID: 40247099
J Clin Microbiol

Antifungal Susceptibility Testing of Malassezia spp. with an Optimized Colorimetric Broth Microdilution Method. [Abstract]

2017 Jun;55(6):1883-1893. PMID: 28381607
Probiotics Antimicrob Proteins

Screening the γ-core Motif Peptides of Ascomycetous Antifungal Proteins for Antifungal Activity and Potential Therapeutic Applicability. [Abstract]

2026 Jan 6. PMID: 41493708
Chem Biol Interact

Micafungin protects mouse heart against doxorubicin-induced oxidative injury via suppressing MALT1-dependent k48-linked ubiquitination of Nrf2. [Abstract]

2024 Sep 1:400:111179. PMID: 39089415
Sci Rep

Biofilm formation of the black yeast-like fungus Exophiala dermatitidis and its susceptibility to antiinfective agents. [Abstract]

2017 Feb 17:7:42886. PMID: 28211475
Appl Microbiol Biotechnol

Aloin remodels the cell wall of Candida albicans to reduce its hyphal virulence against oral candidiasis. [Abstract]

2025 Jan 24;109(1):21. PMID: 39853490
Microorganisms

In Silico Identification and In Vitro Validation of Repurposed Compounds Targeting the RSV Polymerase. [Abstract]

2023 Jun 18;11(6):1608. PMID: 37375110
Microorganisms

Candida albicans Strains Adapted to Caspofungin Due to Aneuploidy Become Highly Tolerant under Continued Drug Pressure. [Abstract]

2022 Dec 21;11(1):23. PMID: 36677315
Antimicrob Agents Chemother

Rapid Evolution of Multidrug Resistance in a Candida lusitaniae Infection during Micafungin Monotherapy. [Abstract]

2023 Aug 17;67(8):e0054323. PMID: 37428075

Micafungin sodium purchased from MedChemExpress. Usage Cited in: Antimicrob Agents Chemother. 2023 Aug 17;67(8):e0054323. [Abstract]

Heatmaps of relative growth at increasing concentrations of Micafungin sodium (MICs) and bar charts of tolerance (supra-MIC growth [SMG]) for three drug classes. The MIC is marked with a yellow bar for each isolate.

Micafungin sodium purchased from MedChemExpress. Usage Cited in: Antimicrob Agents Chemother. 2023 Aug 17;67(8):e0054323. [Abstract]

Growth and mean AUC-L values in 0.016 μg/mL MCF. A single isolate (D1.2) did not reach stationary phase and is labeled on the growth curve.
J Antimicrob Chemother

Antibiofilm activity of antifungal drugs, including the novel drug olorofim, against Lomentospora prolificans. [Abstract]

2020 Aug 1;75(8):2133-2140. PMID: 32386411
mSphere

Triazole Evolution of Candida parapsilosis Results in Cross-Resistance to Other Antifungal Drugs, Influences Stress Responses, and Alters Virulence in an Antifungal Drug-Dependent Manner. [Abstract]

2020 Oct 28;5(5):e00821-20. PMID: 33115837
mSphere

Echinocandin-Induced Microevolution of Candida parapsilosis Influences Virulence and Abiotic Stress Tolerance. [Abstract]

2018 Nov 14;3(6):e00547-18. PMID: 30429225
PLoS Negl Trop Dis

Identification of anti-flaviviral drugs with mosquitocidal and anti-Zika virus activity in Aedes aegypti. [Abstract]

2019 Aug 20;13(8):e0007681. PMID: 31430351
Mycoses

Antifungal susceptibility testing of dermatophytes: Development and evaluation of an optimised broth microdilution method. [Abstract]

2021 Mar;64(3):282-291. PMID: 33084127
Infect Drug Resist

Correlation Between Drug Resistance and Virulence of Candida Isolates from Patients with Candidiasis. [Abstract]

2022 Dec 15:15:7459-7473. PMID: 36544991
J Microbiol Methods

Evaluating β-1,3-glucan synthesis inhibition using emulsion formation as an indicator. [Abstract]

2021 Nov:190:106327. PMID: 34517039
bioRxiv

2026 Jun 30:2026.06.29.735437. PMID: 42427506
University of Szeged

2026.
bioRxiv

Heterogeneity of Candida bloodstream isolates in an academic medical center and affiliated hospitals. [Abstract]

2025 Feb 6:2025.02.05.636768. PMID: 39975022
bioRxiv

2024 May 14.

Lösungsmittel & Löslichkeit

In Vitro:

DMSO : 116.67 mg/mL (90.28 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

View the Complete Stock Solution Preparation Table

Preparing Stock Solutions

View the Complete Stock Solution Preparation Table

Concentration Solvent Mass

1 mg

5 mg

10 mg

Concentration

Solvent

Mass

1 mM

0.7738 mL

3.8692 mL

7.7384 mL

5 mM

0.1548 mL

0.7738 mL

1.5477 mL

10 mM

0.0774 mL

0.3869 mL

0.7738 mL

Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.

Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

Reinheit & Dokumentation

Select Batch:

Reinheit: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (286 KB)
SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

Verweise

[1]. Bazzi W, et al. The inhibitory effect of micafungin on biofilm formation by Pseudomonas aeruginosa. Biofouling. 2013 Jul 23. [Content Brief]

[2]. Kai H, et al. Synergistic antifungal activity of KB425796-C in combination with micafungin against Aspergillus fumigat us and its efficacy in murine infection models. J Antibiot (Tokyo). 2013 Jun 12. [Content Brief]

[3]. Ikeda F, Wakai Y, Matsumoto S, et al. Efficacy of FK463, a new lipopeptide antifungal agent, in mouse models of disseminated candidiasis and aspergillosis. Antimicrob Agents Chemother. 2000;44(3):614-618. [Content Brief]

[4]. Tawara S, Ikeda F, Maki K, et al. In vitro activities of a new lipopeptide antifungal agent, FK463, against a variety of clinically important fungi. Antimicrob Agents Chemother. 2000;44(1):57-62. [Content Brief]

[5]. Mikamo H, Sato Y, Tamaya T. In vitro antifungal activity of FK463, a new water-soluble echinocandin-like lipopeptide. J Antimicrob Chemother. 2000;46(3):485-487. [Content Brief]

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg
DMSO	1 mM	0.7738 mL	3.8692 mL	7.7384 mL	19.3460 mL
	5 mM	0.1548 mL	0.7738 mL	1.5477 mL	3.8692 mL
	10 mM	0.0774 mL	0.3869 mL	0.7738 mL	1.9346 mL
	15 mM	0.0516 mL	0.2579 mL	0.5159 mL	1.2897 mL
	20 mM	0.0387 mL	0.1935 mL	0.3869 mL	0.9673 mL
	25 mM	0.0310 mL	0.1548 mL	0.3095 mL	0.7738 mL
	30 mM	0.0258 mL	0.1290 mL	0.2579 mL	0.6449 mL
	40 mM	0.0193 mL	0.0967 mL	0.1935 mL	0.4836 mL
	50 mM	0.0155 mL	0.0774 mL	0.1548 mL	0.3869 mL
	60 mM	0.0129 mL	0.0645 mL	0.1290 mL	0.3224 mL
	80 mM	0.0097 mL	0.0484 mL	0.0967 mL	0.2418 mL

Bioz

Keywords

Micafungin sodium

22 Cited Publications

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Micafungin sodium

Publications Citing Use of MedChemExpress (MCE) Micafungin sodium

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