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Pepstatin

(Synonyms: Pepstatin A)
69 Cited Publications
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Based on 69 publication(s) in Google Scholar

Pepstatin (Pepstatin A) is a specific, orally active aspartic protease inhibitor produced by actinomycetes, with IC50s of 4.5 nM, 6.2 nM, 150 nM, 290 nM, 520 nM and 260 nM for hemoglobin-pepsin, hemoglobin-proctase, casein-pepsin, casein-proctase, casein-acid protease and hemoglobin-acid protease, respectively. Pepstatin also inhibits HIV protease.

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  • Reinheit : 99.90%
  • CAS. Nr.: 26305-03-3
  • Formel: C34H63N5O9
  • Molecular Weight:685.89
  • Speicherung:

    Sealed storage, away from moisture.

    Powder   -80°C, 2 years , -20°C, 1 year

    * In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

  • Pepstatin Chemical Structure
    Pepstatin Chemical Structure
  • Experimental Validation Results for Pepstatin
  • Experimental Validation Results for Pepstatin
  • Experimental Validation Results for Pepstatin
  • Experimental Validation Results for Pepstatin
  • Experimental Validation Results for Pepstatin
  • Experimental Validation Results for Pepstatin
CAS. Nr.: 26305-03-3
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WBCell Proliferation/Viability AssayCell Imaging/StainingIF
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  • Cell Imaging/Staining
  • Cell Proliferation/Viability Assay
  • WB
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  • Pepstatin Chemical Structure
    Pepstatin Chemical Structure
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  • 1/16

    Pepstatin purchased from MedChemExpress. Usage Cited in: Autophagy. 2025 Jul;21(7):1591-1607. [Abstract]

    Customer Validation
     Representative fluorescence image of tfLC3 under Pepstatin A + E64d condition in primary liver cells from tfLC3-KI mice.

  • 1/16

    Pepstatin purchased from MedChemExpress. Usage Cited in: Nat Commun. 2025 Nov 19;16(1):10181. [Abstract]

    Customer Validation
     WB analyses of LC3 and p62 levels in cells after indicated treatments for 8 h. The relative levels of LC3 and p62 were showed. 3-MA (3-Methyladenine, 10 mM), CQ (Chloroquine, 20 μM), PA (Pepstatin A,10 μg/mL), LP (Leupeptin, 100 μM), Rapa (Rapamycin, 10 nM).

  • 1/16

    Pepstatin purchased from MedChemExpress. Usage Cited in: Nat Commun. 2025 Nov 19;16(1):10181. [Abstract]

    Customer Validation
     Co-immunofluorescence of PRDX1 (red) and LC3 (green) in WT TM3 cells. Cells were treated with or without Chloroquine (20 μM), Pepstatin A (10 μg/mL), or Leupeptin (100 μM) for 8 hours.

  • 1/16

    Pepstatin purchased from MedChemExpress. Usage Cited in: Carbohydr Polym. 2023 Nov 1:319:121208. [Abstract]

    Customer Validation
     The viability of HCT-116 cells pretreated with 5 μM Pepstatin A was detected by CCK8.

  • 1/16

    Pepstatin purchased from MedChemExpress. Usage Cited in: Adv Sci (Weinh). 2022 Oct 10;e2203831. [Abstract]

    Customer Validation
     Wild-type and ATP13A1−/− HEK293T cells were treated with Bafilomycin A1 (200 nM), E-64d (10 µg/mL) or Pepstatin A (10 µg/mL) for 12 h before immunoblotting analysis.

  • 1/16

    Pepstatin purchased from MedChemExpress. Usage Cited in: Pharmaceuticals (Basel). 2022 Dec 3;15(12):1509. [Abstract]

    Customer Validation
     TSN (10 μM), Baf (0.5 μM), and E64D (25 μM) plus pepstatin A (50 μM; E + P ) treatment significantly inhibits the degradation ability of lysosomes (in HepG2 cells and L02 cells; medium for 6 h).

  • Pepstatin