Art. -Nr.: HY-B1180

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Vinburnine

(Synonyms: (-)-Eburnamonine; (-)-Vincamone)

3 Cited Publications

Kundenbewertung

Based on 3 publication(s) in Google Scholar

Vincamone is a vinca alkaloid and a metabolite of vincamine, is a vasodilator.

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Reinheit: 98.30%
CAS. Nr.: 4880-88-0
Formel: C₁₉H₂₂N₂O
Molecular Weight:294.40

Speicherung:

Powder -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month

Vinburnine Chemical Structure

CAS. Nr.: 4880-88-0

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Use of MCE Products

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Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biologische Aktivität
- Beschreibung
- Cellular Effect
- In Vitro
- In Vivo
Chemical Information
Publications (3)
Lösungsmittel & Löslichkeit
- In Vitro
- In Vivo
Reinheit & Dokumentation
Verweise
Help & FAQs
Classifications
Bioz

Biologische Aktivität

Beschreibung

Vincamone is a vinca alkaloid and a metabolite of vincamine, is a vasodilator.

Alle mAChR Isoform-spezifische Produkte anzeigen :

Cellular Effect

Cell Line	Type	Value	Description	References
KMS-12-BM	IC₅₀	>100 μM Compound: 2	Cytotoxicity against human KMS-12-BM cells after 96 hrs by MTS assay Cytotoxicity against human KMS-12-BM cells after 96 hrs by MTS assay	[PMID: 24055047]
LNCaP	IC₅₀	>100 μM Compound: 2	Cytotoxicity against human LNCAP cells after 96 hrs by MTS assay Cytotoxicity against human LNCAP cells after 96 hrs by MTS assay	[PMID: 24055047]
MDA-MB-231	IC₅₀	41.8 μM Compound: 2	Cytotoxicity against human MDA-MB-231 cells after 96 hrs by MTS assay Cytotoxicity against human MDA-MB-231 cells after 96 hrs by MTS assay	[PMID: 24055047]
RPMI-8226	IC₅₀	>100 μM Compound: 2	Cytotoxicity against human RPMI8226 cells after 96 hrs by MTS assay Cytotoxicity against human RPMI8226 cells after 96 hrs by MTS assay	[PMID: 24055047]
U-266	IC₅₀	>100 μM Compound: 2	Cytotoxicity against human U266 cells after 96 hrs by MTS assay Cytotoxicity against human U266 cells after 96 hrs by MTS assay	[PMID: 24055047]

In Vitro

Vinburnine is the allosteric modulator of muscarinic receptors M1-M4, decelerates the binding of ^[H]N-methylscopolamine to muscarinic M1-M4 receptors in CHO cell with EC₅₀s of 29.5, 4.1, 9.5, and 15.0 μM, respectively^[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Vinburnine (5-50 mg/kg, ip, single dose) exhibits anti-amnesia effect in Scopolamine (HY-N0296)-induced mouse amnesia model^[2].
Vinburnine promotes erythrocyte glycolysis, increases erythrocyte ATP and 2,3-diphosphoglycerol content, improves erythrocyte deformability and tissue oxygen delivery^[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

Scopolamine (HY-N0296)-induced mouse amnesia model^[2]
Dosage:

5-50 mg/kg
Administration:

ip, single dose
Result:

Improved memory impairment.

Chemical Information

CAS. Nr. 4880-88-0
Appearance Solid
Molecular Weight 294.40
Formel C₁₉H₂₂N₂O
Color White to off-white
SMILES

O=C1C[C@@]2(CC)[C@@]3([H])C(N1C4=CC=CC=C54)=C5CCN3CCC2
Synonyms

(-)-Eburnamonine; (-)-Vincamone
Structure Classification
- Alkaloids
- Indole Alkaloids
Initial Source
Versand

Room temperature in continental US; may vary elsewhere.

Speicherung

Powder	-20°C	3 years
In solvent	-80°C	6 months
	-20°C	1 month

Publications (3)

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Journal Impact Factor

Adv Sci (Weinh)

Vinburnine Sensitizes Radiotherapy Efficacy in Nasopharyngeal Carcinoma by Triggering Pyroptosis and Immune Responses via Activation of EDAR-NFκB Pathway. [Abstract]

2025 Sep 25:e06139. PMID: 40995667
J Exp Clin Cancer Res

Vinburnine potentiates anti-PD1 immunotherapy in melanoma through IL-24 secretion via P38/MAPK/ATF3 signaling. [Abstract]

2025 Aug 27;44(1):255. PMID: 40866941
University of Granada

2025.

Lösungsmittel & Löslichkeit

In Vitro:

DMSO : 8.33 mg/mL (28.30 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

View the Complete Stock Solution Preparation Table

Preparing Stock Solutions

View the Complete Stock Solution Preparation Table

Concentration Solvent Mass

1 mg

5 mg

10 mg

Concentration

Solvent

Mass

1 mM

3.3968 mL

16.9838 mL

33.9676 mL

5 mM

0.6794 mL

3.3968 mL

6.7935 mL

10 mM

0.3397 mL

1.6984 mL

3.3968 mL

Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.

Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

Stock Solution Working Solution

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline

Solubility: ≥ 0.83 mg/mL (2.82 mM); Clear solution

This protocol yields a clear solution of ≥ 0.83 mg/mL (saturation unknown).

Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (8.3 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.

Protocol 2

Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in Saline)

Solubility: ≥ 0.83 mg/mL (2.82 mM); Clear solution

This protocol yields a clear solution of ≥ 0.83 mg/mL (saturation unknown).

Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (8.3 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.

Protocol 3

Add each solvent one by one: 10% DMSO 90% Corn Oil

Solubility: ≥ 0.83 mg/mL (2.82 mM); Clear solution

This protocol yields a clear solution of ≥ 0.83 mg/mL (saturation unknown). If the continuous dosing period exceeds half a month, please choose this protocol carefully.

Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (8.3 mg/mL) to 900 μL Corn oil, and mix evenly.

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage Dosage
mg/kg
Animal Weight (Per Animal) Animal Weight (Per Animal)
g
Dosing Volume (Per Animal) Dosing Volume (Per Animal)
μL
Number of Animals Number of Animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Please enter your animal formula composition:

%
DMSO +

Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
%
+
+
%
Tween-80 + +
%
Saline +

The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).

Working solution concentration: 0.22 mg/mL

Reinheit & Dokumentation

Select Batch:

Reinheit: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (281 KB)
SDS (419 KB)
- English - EN (419 KB)
- Français - FR (419 KB)
- Deutsch - DE (419 KB)
- Norwegian - NO (419 KB)
- Español - ES (419 KB)
- Swedish - SV (419 KB)
- Italian - IT (419 KB)
- Korean - KR (419 KB)
- Portuguese - PT (419 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

Verweise

[1]. Maksay G, Bíró T, Kiss B. Vinburnine decelerates [3H]N-methylscopolamine binding to recombinant human muscarinic M1-M4 acetylcholine receptors. Eur J Pharmacol. 2004;483(2-3):229-232. [Content Brief]

[2]. Drago F, et al., Effects of vinburnine on experimental models of learning and memory impairments. Pharmacol Biochem Behav. 1990 Sep;37(1):53-7. [Content Brief]

[3]. Vas A, et al., Eburnamine derivatives and the brain. Med Res Rev. 2005 Nov;25(6):737-57. [Content Brief]

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Complete Stock Solution Preparation Table

Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg
DMSO	1 mM	3.3968 mL	16.9838 mL	33.9676 mL	84.9191 mL
	5 mM	0.6794 mL	3.3968 mL	6.7935 mL	16.9838 mL
	10 mM	0.3397 mL	1.6984 mL	3.3968 mL	8.4919 mL
	15 mM	0.2265 mL	1.1323 mL	2.2645 mL	5.6613 mL
	20 mM	0.1698 mL	0.8492 mL	1.6984 mL	4.2460 mL
	25 mM	0.1359 mL	0.6794 mL	1.3587 mL	3.3968 mL

Keywords

Vinburnine

3 Cited Publications

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Publications Citing Use of MedChemExpress (MCE) Vinburnine

Alle mAChR Isoform-spezifische Produkte anzeigen

Biologische Aktivität

Chemical Information

Publications (3)

Lösungsmittel & Löslichkeit

Reinheit & Dokumentation

Verweise

Help & FAQs

Complete Stock Solution Preparation Table

Vinburnine Related Classifications

HY-B1180 Related Classifications