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Art. -Nr.: HY-164894

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ABBV-3373

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Based on 1 Customer Validation

ABBV-3373 is an anti-TNF antibody-drug conjugate (ADC). ABBV-3373 consists of a humanized TNF antibody Adalimumab (HY-P9908) conjugated to a glucocorticoid receptor agonist (HY-148436). ABBV-3373 can be used for the research of rheumatoid arthritis.

Nur für Forschungszwecke. Wir verkaufen nicht an Patienten.

Reinheit: 98.78%

Speicherung:

-80°C, protect from light

ABBV-3373 Chemical Structure

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Biologische Aktivität
- Beschreibung
- In Vivo
- Clinical Trial
Chemical Information
Reinheit & Dokumentation
Verweise
Calculators
Help & FAQs
Classifications
Bioz

Biologische Aktivität

Beschreibung

Alle TNF Receptor Isoform-spezifische Produkte anzeigen :

In Vivo

The ABBV-3373 surrogate (10 mg/kg; i.p.; single administration) achieves a 98% inhibition rate of the area under the paw swelling curve in a mouse collagen-induced arthritis model, with the therapeutic effect lasting for more than 30 days^[1].
The ABBV-3373 surrogate (3-10 mg/kg; single administration) inhibits FITC-induced ear swelling by 55-88% in the Mus musculus contact hypersensitivity model, with minimal effects on systemic glucocorticoid biomarkers^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

DBA/1 (collagen-induced arthritis model)^[1]
Dosage:

10 mg/kg (DAR4 ADC)
Administration:

i.p.; single dose
Result:

Achieved 98% inhibition of paw swelling AUC.
Maintained paw swelling reduction for > 30 days post-dose.

Animal Model:

unspecified^[1]
Dosage:

10 mg/kg; 3 mg/kg
Administration:

single dose (prior to sensitization)
Result:

Inhibited ear swelling by 88%, plasma corticosterone by 15%, and plasma P1NP by 19% (at 10 mg/kg).
Inhibited ear swelling by 55%, plasma corticosterone by 6%, and caused a -16% change (increase) in plasma P1NP (at 3 mg/kg).

Clinical Trial

NCT Number	Sponsor	Condition	Start Date	Phase A549
NCT01329991	Plexxikon\|		2011-05	PHASE1

Chemical Information

Appearance Liquid
Color Colorless to light yellow
SMILES

[ABBV-3373]
Versand

Shipping with dry ice.
Speicherung

-80°C, protect from light

Reinheit & Dokumentation

Select Batch:

Reinheit: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (270 KB)
SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

Verweise

[1]. Hobson AD, et al. Discovery of ABBV-3373, an Anti-TNF Glucocorticoid Receptor Modulator Immunology Antibody Drug Conjugate. J Med Chem. 2022;65(23):15893-15934. [Content Brief]

Calculators

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

MOQ

Minimum order quantity

100 mg

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Biologische Aktivität
- Beschreibung
- In Vivo
- Clinical Trial
Chemical Information
Reinheit & Dokumentation
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ABBV-3373

Alle TNF Receptor Isoform-spezifische Produkte anzeigen

Biologische Aktivität

Chemical Information

Reinheit & Dokumentation

Verweise

Calculators

Help & FAQs

ABBV-3373 Related Classifications

HY-164894 Related Classifications