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Art. -Nr.: HY-116640

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Amorphigenin

Amorphigenin is a trothotenone compound. Amorphigenin inhibits osteoclast differentiation by suppressing the expression of c-Fos and NFATc1 in activated T cells. Amorphigenin degrades melanosome proteins by activating the AMPK-dependent autophagy pathway, but not in dependence of the mTOR pathway. Amorphigenin significantly protects bone mass and reduces bone erosion in a mouse model of inflammatory bone loss. Amorphigenin can be used to study inflammatory bone diseases, postmenopausal osteoporosis, and skin pigmentation disorders.

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CAS. Nr.: 4208-09-7
Formel: C₂₃H₂₂O₇
Molecular Weight:410.42

Speicherung:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (270 KB)

Amorphigenin Chemical Structure

CAS. Nr.: 4208-09-7

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biologische Aktivität
- Beschreibung
- IC₅₀ & Target
- Cellular Effect
Chemical Information
Reinheit & Dokumentation
Verweise
Calculators
Help & FAQs
Classifications
Bioz

Biologische Aktivität

Beschreibung

IC₅₀ & Target^[1]

c-Fos

Alle AP-1 Isoform-spezifische Produkte anzeigen :

Alle AMPK Isoform-spezifische Produkte anzeigen :

Cellular Effect

Cell Line	Type	Value	Description	References
A549	ED₅₀	0.05 μg/mL Compound: 5	Cytotoxicity against human A549 cells Cytotoxicity against human A549 cells	[PMID: 8326318]
HCT-8	ED₅₀	0.03 μg/mL Compound: 5	Cytotoxicity against human HCT8 cells Cytotoxicity against human HCT8 cells	[PMID: 8326318]
KB	ED₅₀	0.04 μg/mL Compound: 5	Cytotoxicity against human KB cells Cytotoxicity against human KB cells	[PMID: 8326318]
LNCaP	ED₅₀	0.3 μM Compound: 7	Cytotoxicity against human LNCAP cells Cytotoxicity against human LNCAP cells	[PMID: 32459967]
LNCaP	ED₅₀	7.9 μg/mL Compound: 7	Cytotoxicity against human LNCAP cells Cytotoxicity against human LNCAP cells	[PMID: 17125241]
Lu1	ED₅₀	4.8 μg/mL Compound: 7	Cytotoxicity against human Lu1 cells Cytotoxicity against human Lu1 cells	[PMID: 17125241]
MCF7	ED₅₀	>20 μg/mL Compound: 7	Cytotoxicity against human MCF7 cells Cytotoxicity against human MCF7 cells	[PMID: 17125241]
P388	ED₅₀	0.04 μg/mL Compound: 5	Cytotoxicity against mouse P388 cells Cytotoxicity against mouse P388 cells	[PMID: 8326318]
RPMI-7951	ED₅₀	0.05 μg/mL Compound: 5	Cytotoxicity against human RPMI7951 cells Cytotoxicity against human RPMI7951 cells	[PMID: 8326318]
TE-671	ED₅₀	<0.01 μg/mL Compound: 5	Cytotoxicity against human TE671 cells Cytotoxicity against human TE671 cells	[PMID: 8326318]

Chemical Information

CAS. Nr. 4208-09-7
Molecular Weight 410.42
Formel C₂₃H₂₂O₇
SMILES

O=C1[C@@]2([C@]([H])(OC3=C1C=CC4=C3C[C@@H](O4)C(CO)=C)COC5=C2C=C(C(OC)=C5)OC)[H]
Structure Classification
- Flavonoids
- Other Flavonoids
Initial Source
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

Please store the product under the recommended conditions in the Certificate of Analysis.

Reinheit & Dokumentation

Select Batch:

Reinheit: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (270 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

Verweise

[1]. Lee KW, et al. Root Extract Induces Autophagy-Mediated Melanosome Degradation in mTOR-Independent- and AMPK-Dependent Manner. Curr Issues Mol Biol. 2022 Jun 29;44(7):2856-2867. [Content Brief]

[2]. Kim BG, et al. Amorphigenin inhibits Osteoclast differentiation by suppressing c-Fos and nuclear factor of activated T cells. Anat Cell Biol. 2010 Dec;43(4):310-6. [Content Brief]

Calculators

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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MOQ

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100 mg

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Biologische Aktivität
- Beschreibung
- IC₅₀ & Target
Chemical Information
Reinheit & Dokumentation
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Amorphigenin

Alle AP-1 Isoform-spezifische Produkte anzeigen

Alle AMPK Isoform-spezifische Produkte anzeigen

Biologische Aktivität

Chemical Information

Reinheit & Dokumentation

Verweise

Calculators

Help & FAQs

Amorphigenin Related Classifications

HY-116640 Related Classifications