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Art. -Nr.: HY-182404

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Anticancer agent 316

Anticancer agent 316 (Compound 1) is an anticancer agent. Anticancer agent 316 exerts anticancer activity against colorectal cancers expressing GPR120. Anticancer agent 316 can be used in the research of colorectal cancer.

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CAS. Nr.: 337495-81-5
Formel: C₃₁H₂₈N₂O₂S
Molecular Weight:492.63

Speicherung:

Please store the product under the recommended conditions in the Certificate of Analysis.

Anticancer agent 316 Chemical Structure

CAS. Nr.: 337495-81-5

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Biologische Aktivität
- Beschreibung
- IC₅₀ & Target
- Cellular Effect
- In Vitro
Chemical Information
Reinheit & Dokumentation
Verweise
Calculators
Help & FAQs
Classifications
Bioz

Biologische Aktivität

Beschreibung

IC₅₀ & Target^[1]

GPR120

Alle Free Fatty Acid Receptor Isoform-spezifische Produkte anzeigen :

Cellular Effect

Cell Line	Type	Value	Description	References
SW480	IC₅₀	23.21 μM Compound: 1	Anticancer activity against human SW480 cells expressing GPR120 assessed as inhibition of cell viability measured after 24 hrs by alamar blue assay Anticancer activity against human SW480 cells expressing GPR120 assessed as inhibition of cell viability measured after 24 hrs by alamar blue assay	[PMID: 33161126]

In Vitro

Anticancer agent 316 (0.39-100 µM; 24-72 h) potently inhibits the growth of colorectal cancer cell line SW480, with a 24-hour IC₅₀ of 23.21-26.69 µM^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Cytotoxicity Assay^[1]

Cell Line:

SW480 human colorectal cancer (CRC) cells expressing GPR120
Concentration:

1 µM (72 h); 10 µM (72 h); 100 µM (72 h); 0.39-100 µM (24 h, 48 h, 72 h)
Incubation Time:

24 h; 48 h; 72 h
Result:

Showed ~90% inhibitory effects on SW480 cell growth at 100 µM for 72 hours.
Exhibited an IC₅₀ of 23.21-26.69 µM after 24-hour treatment.
Increased IC₅₀ to ~50-60 µM after 48 hours.

Chemical Information

CAS. Nr. 337495-81-5
Molecular Weight 492.63
Formel C₃₁H₂₈N₂O₂S
SMILES

O=C1C2=C(C3=C(CC24CCCC4)C=CC=C3)N=C(N1C5=CC=C(C)C=C5)SCC(C6=CC=CC=C6)=O
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

Please store the product under the recommended conditions in the Certificate of Analysis.

Reinheit & Dokumentation

Handling Instructions (2659 KB)

Verweise

[1]. Pal A, et al. In silico and in vitro screening for potential anticancer candidates targeting GPR120. Bioorg Med Chem Lett. 2021 Jan 1;31:127672. [Content Brief]

Calculators

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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Biologische Aktivität
- Beschreibung
- IC₅₀ & Target
- In Vitro
Chemical Information
Reinheit & Dokumentation
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Anticancer agent 316

Alle Free Fatty Acid Receptor Isoform-spezifische Produkte anzeigen

Biologische Aktivität

Chemical Information

Reinheit & Dokumentation

Verweise

Calculators

Help & FAQs

Anticancer agent 316 Related Classifications

HY-182404 Related Classifications