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Art. -Nr.: HY-175421

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ArMan

ArMan is a co-activator of DC-SIGN (CD209) and TLR7. ArMan can selectively bind to DC-SIGN, promoting receptor-mediated endocytosis of the virus-like particle (VLP) platform, thereby enhancing co-binding with TLR7. ArMan can drive dendritic cell activation, shifting the immune response from humoral immunity to type 1 cellular immunity. ArMan can be used in melanoma research.

Nur für Forschungszwecke. Wir verkaufen nicht an Patienten.

Formel: C₁₉H₂₅NO₇
Molecular Weight:379.40

Speicherung:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (268 KB)

ArMan Chemical Structure

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biologische Aktivität
- Beschreibung
- IC₅₀ & Target
- In Vitro
- In Vivo
Chemical Information
Reinheit & Dokumentation
Verweise
Calculators
Help & FAQs
Classifications
Bioz

Biologische Aktivität

Beschreibung

IC₅₀ & Target^[1]

TLR7

Alle Toll-like Receptor (TLR) Isoform-spezifische Produkte anzeigen :

In Vitro

ArMan (8 nM; 30 min) displayed by VLPs exhibits enhanced colocalization with DC-SIGN and TLR7 in human monocyte-derived dendritic cells following 30 min of incubation^[1].
ArMan (8 nM; 24 h) displayed by VLPs induces robust activation of human monocyte-derived dendritic cells, with significantly increased surface expression of CD40, CD80, CD83, and CD86 after 24 h of incubation, dependent on DC-SIGN binding^[1].
ArMan (8 nM; 6 h) displayed by VLPs upregulate TLR7-associated gene expression and hallmark DC activation pathways in human monocyte-derived dendritic cells after 6 h of incubation^[1].
ArMan (8 nM; 32 h) displayed by VLPs induce significantly higher secretion of pro-inflammatory cytokines (TNF-α, IL-6, CXCL10, IL-8, IL-12p70) by human monocyte-derived dendritic cells after 32 h of incubation, dependent on DC-SIGN engagement^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

ArMan (s.c. or i.p.; days 3, 9, 15) delivered via VLPs generates robust, tumor antigen-specific Th1 CD4⁺ and CD8⁺ T cells capable of tumor infiltration, significantly inhibiting melanoma tumor growth, extending survival, and providing long-term protection against tumor recurrence in mice^[1].
ArMan (s.c. or i.p.; days 3, 9, 15) delivered via VLPs functions as a self-adjuvanting cancer vaccine component, inducing robust tumor antigen-specific CD8⁺ T cell responses and supporting anti-tumor efficacy in mice without the need for additional adjuvants^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

Molecular Weight 379.40
Formel C₁₉H₂₅NO₇
SMILES

OC[C@H]([C@H]([C@@H]1O)O)O[C@@H]([C@H]1O)OC2=CC=C(CCNC(CCC#C)=O)C=C2
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

Please store the product under the recommended conditions in the Certificate of Analysis.

Reinheit & Dokumentation

Select Batch:

Reinheit: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (268 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

Verweise

[1]. Lensch V, Gabba A, Hincapie R, et al.. Carbohydrate-Lectin Interactions Reprogram Dendritic Cells to Promote Type 1 Anti-Tumor Immunity. ACS nano. 2024 Oct 01;18(39):26770-26783. [Content Brief]

Calculators

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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MOQ

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100 mg

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Biologische Aktivität
- Beschreibung
- IC₅₀ & Target
- In Vitro
- In Vivo
Chemical Information
Reinheit & Dokumentation
Verweise

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ArMan

Alle Toll-like Receptor (TLR) Isoform-spezifische Produkte anzeigen

Biologische Aktivität

Chemical Information

Reinheit & Dokumentation

Verweise

Calculators

Help & FAQs

ArMan Related Classifications

HY-175421 Related Classifications