BIO5192 (Standard)
BIO5192 (Standard) is the analytical standard of BIO5192 (HY-107589). This product is intended for research and analytical applications. BIO5192 is a selective and potent integrin α4β1 (VLA-4) inhibitor (Kd<10 pM). BIO5192 selectively binds to α4β1 (IC50=1.8 nM) over a range of other integrins. BIO5192 results in a 30-fold increase in mobilization of murine hematopoietic stem and progenitors (HSPCs) over basal levels.
Nur für Forschungszwecke. Wir verkaufen nicht an Patienten.
- CAS. Nr.: 327613-57-0
- Formel: C38H46Cl2N6O8S
- Molecular Weight:817.78
-
Speicherung:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
Biologische Aktivität
-
Chemical Information
- Protokoll
- Reinheit & Dokumentation
- Verweise
-
Help & FAQs
-
HY-12290
Arg-Gly-Asp-SerIntegrin Inhibitor -
HY-107589
BIO5192Integrin α4β1 Inhibitor -
HY-P0023
Cyclo(-RGDfK)αvβ3 Integrin Inhibitor -
HY-P0278
RGDTripeptide -
HY-100226
A-205804E-selectin/ICAM-1 Inhibitor -
HY-18644
CWHM-12αV Integrins Inhibitor -
HY-16141
CilengitideIntegrin Inhibitor -
HY-14951
FirategrastIntegrin Antagonist -
HY-19307
SB-273005αvβ3/αvβ5 Receptor Antagonist -
HY-14126
BIO-1211α4β1 (VLA-4) Inhibitor -
HY-15770
TR-14035α4β7/α4β1 Antagonist -
HY-107588
TC-I 15α2β1 Inhibitor
Biologische Aktivität
Beschreibung
Chemical Information
-
CAS. Nr. 327613-57-0
-
Molecular Weight 817.78
-
Formel C38H46Cl2N6O8S
-
SMILES
O=[S](N(CCC1)[C@@H]1C(N[C@H](C(O)=O)CCNC([C@H](CC(C)C)N(C)C(CC(C=C2)=CC=C2NC(NC(C=CC=C3)=C3C)=O)=O)=O)=O)(C4=CC(Cl)=CC(Cl)=C4)=O
-
Versand
Room temperature in continental US; may vary elsewhere.
-
Speicherung
Please store the product under the recommended conditions in the Certificate of Analysis.
Protokoll
-
Cell Cytotoxicity Assay
Cytotoxicity assays are usually based on the assessment of cell membrane damage, which can also be indirectly detected by measuring cell viability. Detection methods include MTT assay, CKK-8 assay, LDH assay and ATP assay, etc.
Reinheit & Dokumentation
Verweise
[1]. Ramirez P, et al. BIO5192, a small molecule inhibitor of VLA-4, mobilizes hematopoietic stem and progenitor cells. Blood. 2009;114(7):1340‐1343. [Content Brief]
[2]. Leone DR, et al. An assessment of the mechanistic differences between two integrin alpha 4 beta 1 inhibitors, the monoclonal antibody TA-2 and the small molecule BIO5192, in rat experimental autoimmune encephalomyelitis. J Pharmacol Exp Ther. 2003;305(3):1150‐1162. [Content Brief]
Calculators
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
BIO5192 (Standard) Related Classifications
HY-107589R Related Classifications
Powered by Bioz