D-Alanine-d4
Based on 1 Customer Validation
D-Alanine-d4 is the deuterium labeled D-Alanine. D-Alanine is a weak GlyR (inhibitory glycine receptor) and PMBA agonist, with an EC50 of 9 mM for GlyR.
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- Reinheit: 99.97%
- CAS. Nr.: 1202063-27-1
- Formel: C3H3D4NO2
- Molecular Weight:93.12
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Speicherung:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
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Biologische Aktivität
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Chemical Information
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Lösungsmittel & Löslichkeit
- Reinheit & Dokumentation
- Verweise
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Help & FAQs
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Biologische Aktivität
Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
1. This compound can be used as a tracer
2. This compound can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS.
Chemical Information
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CAS. Nr. 1202063-27-1
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Unlabeled Cas 338-69-2
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Appearance Solid
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Molecular Weight 93.12
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Formel C3H3D4NO2
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Color White to off-white
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SMILES
N[C@@](C([2H])([2H])[2H])([2H])C(O)=O
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Synonyms
(R)-Alanine-d4; Ba 2776-d4; D-α-Alanine-d4
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Lösungsmittel & Löslichkeit
H2O : ≥ 125 mg/mL (1342.35 mM)
* "≥" means soluble, but saturation unknown.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
Reinheit & Dokumentation
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Data Sheet (275 KB)
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SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
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Handling Instructions (2659 KB)
Verweise
[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216. [Content Brief]
[2]. Schmieden V, et al. Pharmacology of the inhibitory glycine receptor: agonist and antagonist actions of amino acids and piperidine carboxylic acid compounds. Mol Pharmacol. 1995 Nov;48(5):919-27. [Content Brief]
[3]. Saitoh T, et al. A novel antagonist, phenylbenzene omega-phosphono-alpha-amino acid, for strychnine-sensitive glycine receptors in the rat spinal cord. Br J Pharmacol. 1994 Sep;113(1):165-70. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| H2O | 1 mM | 10.7388 mL | 53.6942 mL | 107.3883 mL | 268.4708 mL |
| 5 mM | 2.1478 mL | 10.7388 mL | 21.4777 mL | 53.6942 mL | |
| 10 mM | 1.0739 mL | 5.3694 mL | 10.7388 mL | 26.8471 mL | |
| 15 mM | 0.7159 mL | 3.5796 mL | 7.1592 mL | 17.8981 mL | |
| 20 mM | 0.5369 mL | 2.6847 mL | 5.3694 mL | 13.4235 mL | |
| 25 mM | 0.4296 mL | 2.1478 mL | 4.2955 mL | 10.7388 mL | |
| 30 mM | 0.3580 mL | 1.7898 mL | 3.5796 mL | 8.9490 mL | |
| 40 mM | 0.2685 mL | 1.3424 mL | 2.6847 mL | 6.7118 mL | |
| 50 mM | 0.2148 mL | 1.0739 mL | 2.1478 mL | 5.3694 mL | |
| 60 mM | 0.1790 mL | 0.8949 mL | 1.7898 mL | 4.4745 mL | |
| 80 mM | 0.1342 mL | 0.6712 mL | 1.3424 mL | 3.3559 mL | |
| 100 mM | 0.1074 mL | 0.5369 mL | 1.0739 mL | 2.6847 mL |
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
D-Alanine-d4 Related Classifications
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