Difenoconazole
Based on 3 publication(s) in Google Scholar
Difenoconazole is a sterol demethylation inhibitor, as a fungicide. Difenoconazole binds the heme portion of the fungal cytochrome P450 51, interferes the mycelial growth and inhibits the spore germination of pathogens, suppressing fungal growth.
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- Reinheit: 99.94%
- CAS. Nr.: 119446-68-3
- Formel: C19H17Cl2N3O3
- Molecular Weight:406.26
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Speicherung:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
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Biologische Aktivität
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Chemical Information
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Lösungsmittel & Löslichkeit
- Reinheit & Dokumentation
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Publications Citing Use of MedChemExpress (MCE) Difenoconazole
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Biologische Aktivität
Difenoconazole inhibits the growth of Fusarium graminearum with an EC50 of 1.69-19.6 mg/L[2].
Difenoconazole inhibits growth of Alternaria solani, Fulvia fulva,Botrytis cinerea, and Rhizoctonia solani with EC50s of 0.131, 0.069, 0.297, and 0.252 mg/L, respectively[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Zebrafish[1]
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Dosage:0.25, 0.5, 1, 1.5 and 2 mg/L
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Administration:Exposure for 96 h
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Result:Caused significant body color blackening and decrease in the heart rate of zebrafish larvae over 24 h at 0.5 mg/L.
Inhibited the growth weight of adult zebrafish measured after 14 days' exposure at 0.25 mg/L.
Chemical Information
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CAS. Nr. 119446-68-3
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Appearance Solid
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Molecular Weight 406.26
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Formel C19H17Cl2N3O3
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Color White to off-white
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SMILES
CC1OC(CN2N=CN=C2)(C3=CC=C(OC4=CC=C(Cl)C=C4)C=C3Cl)OC1
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Publications (3)
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Journal Impact Factor
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Most Recent
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Food Res Int
Analysis of pesticide residues in açaí-based food products: an approach using polymeric ionic liquid-based solid-phase microextraction coupled to gas chromatography-mass spectrometry. [Abstract]2025 Dec;222(Pt 2):117720. PMID: 41271335 -
Virulence
2025 Dec;16(1):2472877. PMID: 40033930 -
Fish Physiol Biochem
Curcumin protects against difenoconazole-induced kidney injury in carp by inhibiting ferroptosis through the Nrf2/GPX4 axis. [Abstract]2026 Mar 5;52(2):40. PMID: 41784886
Lösungsmittel & Löslichkeit
DMSO : 100 mg/mL (246.15 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
Select the appropriate dissolution method based on your experimental animal and administration route.
- For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
- To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
- The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline
Solubility: ≥ 2.5 mg/mL (6.15 mM); Clear solution
This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.
Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in Saline)
Solubility: ≥ 2.5 mg/mL (6.15 mM); Clear solution
This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.
Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.
Please enter the basic information of animal experiments:
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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Please enter your animal formula composition:
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%DMSO +
Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
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%+
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+%Tween-80 + +
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%Saline +
The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).
Working solution concentration: 0.22 mg/mL
Method for preparing stock solution: mg drug dissolved in μL DMSO. Stock solution concentration: mg/mL.
1. Take μL DMSO stock solution;
2. Add μL .
μL , mix evenly;
3. Then add μL Tween 80, mix evenly;
4. Then add μL
Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
Reinheit & Dokumentation
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Data Sheet (276 KB)
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SDS (596 KB)
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Handling Instructions (2659 KB)
Verweise
[1]. Mu X, et al. Evaluation of acute and developmental effects of difenoconazole via multiple stage zebrafish assays. Environ Pollut. 2013 Apr;175:147-57. [Content Brief]
[2]. Dong F, et al. Chiral triazole fungicide difenoconazole: absolute stereochemistry, stereoselective bioactivity, aquatic toxicity, and environmental behavior in vegetables and soil. Environ Sci Technol. 2013 Apr 2;47(7):3386-94. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
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| DMSO | 1 mM | 2.4615 mL | 12.3074 mL | 24.6148 mL | 61.5369 mL |
| 5 mM | 0.4923 mL | 2.4615 mL | 4.9230 mL | 12.3074 mL | |
| 10 mM | 0.2461 mL | 1.2307 mL | 2.4615 mL | 6.1537 mL | |
| 15 mM | 0.1641 mL | 0.8205 mL | 1.6410 mL | 4.1025 mL | |
| 20 mM | 0.1231 mL | 0.6154 mL | 1.2307 mL | 3.0768 mL | |
| 25 mM | 0.0985 mL | 0.4923 mL | 0.9846 mL | 2.4615 mL | |
| 30 mM | 0.0820 mL | 0.4102 mL | 0.8205 mL | 2.0512 mL | |
| 40 mM | 0.0615 mL | 0.3077 mL | 0.6154 mL | 1.5384 mL | |
| 50 mM | 0.0492 mL | 0.2461 mL | 0.4923 mL | 1.2307 mL | |
| 60 mM | 0.0410 mL | 0.2051 mL | 0.4102 mL | 1.0256 mL | |
| 80 mM | 0.0308 mL | 0.1538 mL | 0.3077 mL | 0.7692 mL | |
| 100 mM | 0.0246 mL | 0.1231 mL | 0.2461 mL | 0.6154 mL |
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