Art. -Nr.: HY-118060

Dipeptide 2

(Synonyms: N-Valyltryptophan; Val-Trp)

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Dipeptide 2 (N-Valyltryptophan) is an orally active, competitive angiotensin-converting enzyme (ACE) inhibitory peptide with an IC₅₀ of 10.50 μM. Dipeptide 2 reduces intracellular Calcium ions. Dipeptide 2 significantly increases the content of NO, inhibits the production of ET-1, and induces the phosphorylation of eNOS. Dipeptide 2 decreases the systolic and diastolic blood pressure of spontaneously hypertensive rats.

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Reinheit: 98.12%
CAS. Nr.: 24587-37-9
Formel: C₁₆H₂₁N₃O₃
Molecular Weight:303.36

Speicherung:

Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month

Dipeptide 2 Chemical Structure

CAS. Nr.: 24587-37-9

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Biologische Aktivität
- Beschreibung
- IC₅₀ & Target
- Cellular Effect
- In Vitro
- In Vivo
Chemical Information
Lösungsmittel & Löslichkeit
- In Vitro
Reinheit & Dokumentation
Verweise
Help & FAQs
Classifications
Bioz

Biologische Aktivität

Beschreibung

IC₅₀ & Target^[1]

eNOS

Alle Calcium Channel Isoform-spezifische Produkte anzeigen :

Alle NO Synthase Isoform-spezifische Produkte anzeigen :

Cellular Effect

Cell Line	Type	Value	Description	References
MDCK	EC₅₀	0.04 mM Compound: 79	Activation of human PEPT1 expressed in MDCK cells Activation of human PEPT1 expressed in MDCK cells	[PMID: 16759105]
MDCK	IC₅₀	0.1 mM Compound: 79	Binding affinity to human PEPT1 assessed as inhibition of [14C]Gly-Sar uptake in MDCK cells Binding affinity to human PEPT1 assessed as inhibition of [14C]Gly-Sar uptake in MDCK cells	[PMID: 16759105]

In Vitro

Dipeptide 2 potently inhibits purified ACE with an IC₅₀ of 10.50 ± 0.97 μM^[2].
Dipeptide 2 (12.5-50 μM; 24 h) is non-toxic to HUVECs^[2].
Dipeptide 2 (12.5-50 μM; 4 h) reduces intracellular calcium concentration in Ang I-induced HUVECs, promoting vascular smooth muscle relaxation^[2].
Dipeptide 2 (12.5-50 μM; 4 h) promotes NO production in Ang I-induced HUVECs, with a 12.9% increase at 50 μM^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Western Blot Analysis^[2]

Cell Line:

Ang I-induced human umbilical vein endothelial cells (HUVECs)
Concentration:

12.5-50 μM
Incubation Time:

4 h
Result:

Significantly inhibited ET-1 protein expression and stimulated eNOS phosphorylation compared to the Ang I-only group.
Caused a 60.4% reduction in ET-1 and a 92.9% increase in p-eNOS protein expression in the 50 μM group.

In Vivo

Dipeptide 2 (10-40 mg/kg; p.o.; once daily; for 12 consecutive days) exerts significant in vivo hypotensive activity in spontaneously hypertensive rats^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

SHRs (male, 8 weeks old, 220 ± 20 g, spontaneously hypertensive model)^[2]
Dosage:

10 mg/kg; 40 mg/kg
Administration:

p.o.; once daily; 12 days
Result:

Significantly suppressed diastolic blood pressure (DBP) in SHRs between days 8 and 12, with DBP reductions ranging from 3 to 27 mmHg.
Produced a maximum DBP reduction of 27 mmHg on day 12 at 40 mg/kg.
Reduced systolic blood pressure (SBP) by 32 mmHg on day 12.

Chemical Information

CAS. Nr. 24587-37-9
Appearance Solid
Molecular Weight 303.36
Formel C₁₆H₂₁N₃O₃
Color White to off-white
Synonyms

N-Valyltryptophan; Val-Trp
Sequence

Val-Trp
Sequence Shortening

VW
Versand

Room temperature in continental US; may vary elsewhere.

Speicherung

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Lösungsmittel & Löslichkeit

In Vitro:

DMSO : 12.5 mg/mL (41.21 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

View the Complete Stock Solution Preparation Table

Preparing Stock Solutions

View the Complete Stock Solution Preparation Table

Concentration Solvent Mass

1 mg

5 mg

10 mg

Concentration

Solvent

Mass

1 mM

3.2964 mL

16.4821 mL

32.9641 mL

5 mM

0.6593 mL

3.2964 mL

6.5928 mL

10 mM

0.3296 mL

1.6482 mL

3.2964 mL

Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.

Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

Reinheit & Dokumentation

Select Batch:

Reinheit: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (279 KB)
SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

Verweise

[1]. Xu Y, et al. An angiotensin-converting enzyme inhibitory peptide (Val-Trp) from cauliflower by-products exerts an antihypertensive effect via the eNOS/NO/cGMP pathway. Food Funct. 2025;16(10):4048-4060. Published 2025 May 19. [Content Brief]

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Complete Stock Solution Preparation Table

Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg
DMSO	1 mM	3.2964 mL	16.4821 mL	32.9641 mL	82.4103 mL
	5 mM	0.6593 mL	3.2964 mL	6.5928 mL	16.4821 mL
	10 mM	0.3296 mL	1.6482 mL	3.2964 mL	8.2410 mL
	15 mM	0.2198 mL	1.0988 mL	2.1976 mL	5.4940 mL
	20 mM	0.1648 mL	0.8241 mL	1.6482 mL	4.1205 mL
	25 mM	0.1319 mL	0.6593 mL	1.3186 mL	3.2964 mL
	30 mM	0.1099 mL	0.5494 mL	1.0988 mL	2.7470 mL
	40 mM	0.0824 mL	0.4121 mL	0.8241 mL	2.0603 mL

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Dipeptide 2

Immunology/Inflammation Compound Library

Membrane Transporter/Ion Channel Compound Library

Metabolism/Protease Compound Library

Neuronal Signaling Compound Library

Anti-Aging Compound Library

Anti-Cardiovascular Disease Compound Library

Orally Active Compound Library

Angiogenesis-Related Compound Library

Peptide Library

Human Metabolite Library

Antihypertensive Compound Library

Metabolic Enzyme Compound Library

Protease Inhibitor Library

Membrane Protein-targeted Compound Library

Membrane Receptor-targeted Compound Library

Ion Channel Compound Library

Multi-Target Compound Library

Bioactive Compound Library Max

MCE Bioactive Compound Library

Peptide Compound Library

Bioactive Compound Library

High-Throughput Bioactive Compound Library

Mass Spectrometry Human Metabolite Library

Cosmetic Ingredient Compound Library

Alle Calcium Channel Isoform-spezifische Produkte anzeigen

Alle NO Synthase Isoform-spezifische Produkte anzeigen

Biologische Aktivität

Chemical Information

Lösungsmittel & Löslichkeit

Reinheit & Dokumentation

Verweise

Help & FAQs

Complete Stock Solution Preparation Table

Dipeptide 2

Immunology/Inflammation Compound Library

Membrane Transporter/Ion Channel Compound Library

Metabolism/Protease Compound Library

Neuronal Signaling Compound Library

Anti-Aging Compound Library

Anti-Cardiovascular Disease Compound Library

Orally Active Compound Library

Angiogenesis-Related Compound Library

Peptide Library

Human Metabolite Library

Antihypertensive Compound Library

Metabolic Enzyme Compound Library

Protease Inhibitor Library

Membrane Protein-targeted Compound Library

Membrane Receptor-targeted Compound Library

Ion Channel Compound Library

Multi-Target Compound Library

Bioactive Compound Library Max

MCE Bioactive Compound Library

Peptide Compound Library

Bioactive Compound Library

High-Throughput Bioactive Compound Library

Mass Spectrometry Human Metabolite Library

Cosmetic Ingredient Compound Library

Alle Calcium Channel Isoform-spezifische Produkte anzeigen

Alle NO Synthase Isoform-spezifische Produkte anzeigen

Biologische Aktivität

Chemical Information

Lösungsmittel & Löslichkeit

Reinheit & Dokumentation

Verweise

Help & FAQs

Complete Stock Solution Preparation Table

Dipeptide 2 Related Classifications

HY-118060 Related Classifications