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Molnupiravir

(Synonyms: EIDD-2801; MK-4482)
74 Cited Publications
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Based on 74 publication(s) in Google Scholar

Molnupiravir (EIDD-2801) is an orally bioavailable proagent of the ribonucleoside analog EIDD-1931. Molnupiravir has broad spectrum antiviral activity against influenza virus and multiple coronaviruses, such as SARS-CoV-2, MERS-CoV, SARS-CoV. Molnupiravir has the potential for the research of COVID-19, and seasonal and pandemic influenza.

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  • Reinheit: 99.85%
  • CAS. Nr.: 2492423-29-5
  • Formel: C13H19N3O7
  • Molecular Weight:329.31
  • Speicherung:
    Powder   -20°C, 3 years , 4°C, 2 years ; In solvent   -80°C, 6 months , -20°C, 1 month
  • Molnupiravir Chemical Structure
    Molnupiravir Chemical Structure
  • Experimental Validation Results for Molnupiravir
  • Experimental Validation Results for Molnupiravir
  • Experimental Validation Results for Molnupiravir
  • Experimental Validation Results for Molnupiravir
  • Experimental Validation Results for Molnupiravir
CAS. Nr.: 2492423-29-5
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  • Molnupiravir Chemical Structure
    Molnupiravir Chemical Structure
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    Molnupiravir purchased from MedChemExpress. Usage Cited in: Nature. 2022 Jul;607(7917):119-127. [Abstract]

    Customer Validation
     Syrian hamsters were intranasally inoculated with 103 PFU of BA.2 (NCD1288). One day after infection, hamsters were treated with: 500 mg/kg Molnupiravir, 1,000 mg/kg nirmatrelvir or 60 mg/kg S-217622 orally twice daily for 3 days. Methylcellulose served as a control for oral treatment. Eight hamsters per group were euthanized at 4 dpi for virus titration. Viral titres in the nasal turbinates and lungs were determined by plaque assay. For comparison of the lung and nasal turbinate titres of BA.2 (NCD1288)-and D614G (HP095)-infected hamster groups, we used a Kruskal-Wallis test with Dunn's multiple comparisons and one-way ANOVA with Dunnett's multiple comparisons, respectively. Data are from one experiment.

  • 1/16

    Molnupiravir purchased from MedChemExpress. Usage Cited in: Nature. 2022 Apr;604(7904):134-140. [Abstract]

    Customer Validation
     BLISS analysis in Calu-3 cells with molnupiravir or remdesivir in combination with the DHODH inhibitors Brequinar.

  • 1/16

    Molnupiravir purchased from MedChemExpress. Usage Cited in: Nature. 2022 Apr;604(7904):134-140. [Abstract]

    Customer Validation
     Wild-type BALB/C mice were treated with Brequinar (intraperitoneal administration) and/or Molnupiravir (oral administration) daily at the indicated concentrations starting 12 h before infection. Mice (n = 5 per group over 2 independent experiments) were intranasally inoculated with 1 × 105 p.f.u. per mouse of SARS-CoV-2 (B.1.351). Lungs were analysed for viral titre 2 days after infection by plaque assay.

  • 1/16

    Molnupiravir purchased from MedChemExpress. Usage Cited in: Nature. 2022 Apr;604(7904):134-140. [Abstract]

    Customer Validation
     Wild-type BALB/C mice were treated with Brequinar (intraperitoneal administration) and/or Molnupiravir (oral administration) daily at the indicated concentrations starting 12 h before infection. Mice (n = 5 per group over 2 independent experiments) were intranasally inoculated with 1 × 105 p.f.u. per mouse of SARS-CoV-2 (B.1.351). Fixed in 4% paraformaldehyde for haematoxylin and eosin staining and quantified for interstitial inflammation.

  • 1/16

    Molnupiravir purchased from MedChemExpress. Usage Cited in: Nat Microbiol. 2022 Aug;7(8):1252-1258. [Abstract]

    Customer Validation
     Syrian hamsters were intranasally inoculated with 103 PFU of BA.1 (NC928). At 24 h post-infection, hamsters were treated with: 500 mg/kg Molnupiravir orally twice daily for 3 days or 60 mg/kg S-217622 orally twice daily for 3 days. Methylcellulose served as a control for oral treatment. Hamsters were euthanized on Days 2, 3, and 4 post-infection for virus titration. Vertical bars show the mean ± s.e.m. Points indicate data from individual hamsters (n = 4/group).

  • Molnupiravir