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Art. -Nr.: HY-N3883

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Euxanthone

Name: Euxanthone
Brand: MedChemExpress
SKU: HY-N3883
Price: 250.00 USD
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Euxanthone, a xanthone derivative, attenuates Aβ1-42-induced oxidative stress and apoptosis by triggering autophagy. Euxanthone exhibits anti-neoplastic and neuroprotective activities.

Nur für Forschungszwecke. Wir verkaufen nicht an Patienten.

Reinheit: 99.96%
CAS. Nr.: 529-61-3
Formel: C₁₃H₈O₄
Molecular Weight:228.20

Speicherung:

-20°C, protect from light

* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Euxanthone Chemical Structure

CAS. Nr.: 529-61-3

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biologische Aktivität
- Beschreibung
- Cellular Effect
- In Vitro
- In Vivo
Chemical Information
Reinheit & Dokumentation
Verweise
Calculators
Help & FAQs
Classifications
Bioz

Biologische Aktivität

Beschreibung

Euxanthone, a xanthone derivative, attenuates Aβ1-42-induced oxidative stress and apoptosis by triggering autophagy. Euxanthone exhibits anti-neoplastic and neuroprotective activities^[1]^[2]^[3].

Cellular Effect

Cell Line	Type	Value	Description	References
A549	IC₅₀	>200 μM Compound: 8	Cytotoxicity against Taxol-resistant human A549 cells measured after 48 hrs by MTT assay Cytotoxicity against Taxol-resistant human A549 cells measured after 48 hrs by MTT assay	[PMID: 28065566]
A549	IC₅₀	14.5 mg/mL Compound: 13	Cytotoxicity against human A549 cells after 3 days by SRB assay Cytotoxicity against human A549 cells after 3 days by SRB assay	[PMID: 15568778]
HeLa S3	IC₅₀	>10 μM Compound: 19	Cytotoxicity in human HeLaS3 cells incubated for 72 hrs by MTT assay Cytotoxicity in human HeLaS3 cells incubated for 72 hrs by MTT assay	[PMID: 30978023]
HepG2	IC₅₀	>10 μM Compound: 19	Cytotoxicity in human HepG2 cells incubated for 72 hrs by MTT assay Cytotoxicity in human HepG2 cells incubated for 72 hrs by MTT assay	[PMID: 30978023]
HT-29	IC₅₀	>10 μM Compound: 19	Cytotoxicity in human HT-29 cells incubated for 72 hrs by MTT assay Cytotoxicity in human HT-29 cells incubated for 72 hrs by MTT assay	[PMID: 30978023]
KB	IC₅₀	>10 μM Compound: 19	Cytotoxicity in human KB cells incubated for 72 hrs by MTT assay Cytotoxicity in human KB cells incubated for 72 hrs by MTT assay	[PMID: 30978023]
MCF7	IC₅₀	>10 μM Compound: 19	Cytotoxicity in human MCF7 cells incubated for 72 hrs by MTT assay Cytotoxicity in human MCF7 cells incubated for 72 hrs by MTT assay	[PMID: 30978023]
MCF7	IC₅₀	19.5 mg/mL Compound: 13	Cytotoxicity against human MCF7 cells after 3 days by SRB assay Cytotoxicity against human MCF7 cells after 3 days by SRB assay	[PMID: 15568778]
NCI/ADR-RES	IC₅₀	>200 μM Compound: 8	Cytotoxicity against human MCF7/ADR cells measured after 48 hrs by MTT assay Cytotoxicity against human MCF7/ADR cells measured after 48 hrs by MTT assay	[PMID: 28065566]
OVCAR-3	IC₅₀	>10 μM Compound: 27	Antiproliferative activity against human OVCAR3 cells assessed as reduction in cell viability after 48 hrs by CCK8 assay Antiproliferative activity against human OVCAR3 cells assessed as reduction in cell viability after 48 hrs by CCK8 assay	[PMID: 30830783]
SK-OV-3	IC₅₀	>10 μM Compound: 27	Antiproliferative activity against human SKOV3 cells assessed as reduction in cell viability after 48 hrs by CCK8 assay Antiproliferative activity against human SKOV3 cells assessed as reduction in cell viability after 48 hrs by CCK8 assay	[PMID: 30830783]
SMMC-7721	IC₅₀	60.35 μM Compound: 8	Cytotoxicity against Taxol-resistant human SMMC7721 cells measured after 48 hrs by MTT assay Cytotoxicity against Taxol-resistant human SMMC7721 cells measured after 48 hrs by MTT assay	[PMID: 28065566]

In Vitro

Euxanthone (10-20 μM; 24 h) compromises the capability of OS cells to migrate in a dose-dependent fashion, and significantly suppresses cell invasion. Euxanthone presents a significant decrease in adhesion to fibronectin^[1].
Euxanthone (10-20 μM; 24 h) modulates the COX-2 expression through the miR-21/PDCD4/c-jun signaling pathway. The repression of COX-2 by Euxanthone mediated its anti-metastatic activities^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Migration Assay ^[1]

Cell Line:

Osteosarcoma (OS) cells
Concentration:

10 μM, 20 μM
Incubation Time:

24 h
Result:

Inhibited cell migration at 24 hr.

Western Blot Analysis^[1]

Cell Line:

Osteosarcoma (OS) cells
Concentration:

10 μM, 20 μM
Incubation Time:

24 h
Result:

Repressed both the mRNA and protein level of COX-2 in OS cells in a dose-dependent fashion.

In Vivo

Euxanthone (40-80 mg/kg) could significantly decrease the number of metastatic nodules in lung tissue in a pulmonary metastasis model^[1].
Euxanthone (30-60 mg/kg; p.o.;once a day; for 7 days) treatment normalized Bnip3, Beclin1, Pink1, Parkin, p53, Bax, caspase-3, and LC3 II/I in bearing bilateral common carotid artery occlusion (BCCAO). Euxanthone modulates mitophagy and apoptosis induces by mitochondrial stress mediated by mitochondrial fragmentation^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

Forty male ICR mice (20 g) induced cerebral ischemia and reperfusion^[2]
Dosage:

30 mg/kg, 60 mg/kg
Administration:

p.o.;once a day; for 7 days
Result:

Markedly attenuated BCCAO triggered mitochondrial stress and related breakdown.

Chemical Information

CAS. Nr. 529-61-3
Appearance Solid
Molecular Weight 228.20
Formel C₁₃H₈O₄
Color Light yellow to yellow
SMILES

O=C1C2=C(OC3=C1C=C(O)C=C3)C=CC=C2O
Structure Classification
- Flavonoids
- Other Flavonoids
Initial Source
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

-20°C, protect from light

* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Reinheit & Dokumentation

Select Batch:

Reinheit: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (274 KB)
SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

Verweise

[1]. Xiaodong Chen, et al. Euxanthone Impairs the Metastatic Potential of Osteosarcoma by Reducing COX-2 Expression. Anat Rec (Hoboken). 2019 Aug;302(8):1399-1408. [Content Brief]

[2]. Wei Sun, et al. Euxanthone improves cognitive impairment by attenuating mitochondrial fragmentation and suppressing oxidative stress. Cent Eur J Immunol. 2021;46(4):446-455. [Content Brief]

[3]. aicheng Yuan, et al. Euxanthone Attenuates Aβ1-42-Induced Oxidative Stress and Apoptosis by Triggering Autophagy. J Mol Neurosci. 2018 Dec;66(4):512-523. [Content Brief]

Calculators

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

Keywords

MOQ

Minimum order quantity

100 mg

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