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Art. -Nr.: HY-182729

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FFA2 agonist-2

FFA2 agonist-2 is a potent agonist of the FFA2 (GPR43) receptor, with a pEC₅₀ of 7.9 for human FFA2, and a pEC₅₀ of 7.3 for murine FFA2. FFA2 agonist-2 acts as an orthosteric agonist and shows no obvious cross‑activity against FFA1, FFA3 and FFA4. FFA2 agonist-2 can be used for FFA2 receptor research in type 2 diabetes and metabolic disorders.

Nur für Forschungszwecke. Wir verkaufen nicht an Patienten.

CAS. Nr.: 1229363-11-4
Formel: C₂₃H₂₀Cl₂N₂O₃S
Molecular Weight:475.39

Speicherung:

Please store the product under the recommended conditions in the Certificate of Analysis.

FFA2 agonist-2 Chemical Structure

CAS. Nr.: 1229363-11-4

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biologische Aktivität
- Beschreibung
- IC₅₀ & Target
- In Vitro
- Parmacokinetics
- In Vivo
Chemical Information
Reinheit & Dokumentation
Verweise
Calculators
Help & FAQs
Classifications
Bioz

Biologische Aktivität

Beschreibung

IC₅₀ & Target

^[1]

FFAR2

7.9 (pEC₅₀, 人源)

FFAR2

7.3 (pEC₅₀, 鼠源)

Alle Free Fatty Acid Receptor Isoform-spezifische Produkte anzeigen :

In Vitro

FFA2 agonist-2 (compound 8) acts as a potent agonist at both hFFA2 and mFFA2 receptors in CHO cells, with a pEC₅₀ of 7.9 (hFFA2) and 7.3 (mFFA2), and binds to hFFA2 with a pK_i of 6.7^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Parmacokinetics

Species	Dose	Route	CL_unbound	T_1/2	F
Rat^[1]	1 mg/kg	i.v.	2800 mL/min/kg	590 min	/
Rat^[1]	3 mg/kg	p.o.	/	/	47 %

In Vivo

FFA2 agonist-2 (compound 8) (50 mg/kg; p.o.; single dose) does not produce a statistically significant reduction in peak blood glucose levels in a mouse OGTT model^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Related Protocols :

Research Protocol for Metabolic Diseases

Chemical Information

CAS. Nr. 1229363-11-4
Molecular Weight 475.39
Formel C₂₃H₂₀Cl₂N₂O₃S
SMILES

OC(C[C@@H](CC1=CC=CC=C1)C(N(C2CC2)C3=NC(C4=C(C=CC(Cl)=C4)Cl)=CS3)=O)=O
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

Please store the product under the recommended conditions in the Certificate of Analysis.

Reinheit & Dokumentation

Handling Instructions (2659 KB)

Verweise

[1]. Hoveyda HR, et al. N-Thiazolylamide-based free fatty-acid 2 receptor agonists: Discovery, lead optimization and demonstration of off-target effect in a diabetes model. Bioorg Med Chem. 2018;26(18):5169-5180. [Content Brief]

Calculators

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

Keywords

MOQ

Minimum order quantity

100 mg

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