FKB04
Based on 1 Customer Validation
FKB04 is a telomeric repeat binding factor 2 (TRF2) inhibitor that exerts its antitumor activity by disrupting the telomere maintenance mechanism in liver cancer cells, leading to T-loop defects, telomere shortening, and cellular senescence. Additionally, FKB04 can inhibit tumor growth in a human liver cancer xenograft mouse model (with Huh-7 cells implanted in BALB/c mice). FKB04 can be used in liver cancer research.
Nur für Forschungszwecke. Wir verkaufen nicht an Patienten.
- Reinheit: 99.98%
- CAS. Nr.: 108979-07-3
- Formel: C17H15BrO4
- Molecular Weight:363.20
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Speicherung:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biologische Aktivität
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Chemical Information
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Lösungsmittel & Löslichkeit
- Reinheit & Dokumentation
- Verweise
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Help & FAQs
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Cell Cycle/DNA Damage Compound Library
HY-L004
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Anti-Cancer Compound Library
HY-L025
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Anti-Aging Compound Library
HY-L034
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Anti-Liver Cancer Compound Library
HY-L101
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Bioactive Compound Library Max
HY-L181
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MCE Bioactive Compound Library
HY-L001V
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Bioactive Compound Library
HY-L001
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High-Throughput Bioactive Compound Library
HY-L205
Biologische Aktivität
Telomere repeat binding factor 2 (TRF2)[1]
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| A549 | IC50 |
12.3 μM
Compound: 10f
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Inhibition of TNFalpha induced NF-kappaB activation in human A549 cells by luciferase reporter gene assay
Inhibition of TNFalpha induced NF-kappaB activation in human A549 cells by luciferase reporter gene assay
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[PMID: 19883086] |
| NIH3T3 | IC50 |
2.2 μM
Compound: 2g
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Inhibition of cobalt chloride-induced HIF-1 activation expressed in mouse NIH3T3 cells after 8 hrs by luciferase reporter gene assay
Inhibition of cobalt chloride-induced HIF-1 activation expressed in mouse NIH3T3 cells after 8 hrs by luciferase reporter gene assay
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[PMID: 21112783] |
Chemical Information
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CAS. Nr. 108979-07-3
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Appearance Solid
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Molecular Weight 363.20
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Formel C17H15BrO4
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Color Light yellow to yellow
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SMILES
BrC1=CC(/C=C/C(C2=C(C=C(C=C2O)OC)OC)=O)=CC=C1
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Lösungsmittel & Löslichkeit
DMSO : 100 mg/mL (275.33 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
Reinheit & Dokumentation
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Data Sheet (270 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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Handling Instructions (2659 KB)
Verweise
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 2.7533 mL | 13.7665 mL | 27.5330 mL | 68.8326 mL |
| 5 mM | 0.5507 mL | 2.7533 mL | 5.5066 mL | 13.7665 mL | |
| 10 mM | 0.2753 mL | 1.3767 mL | 2.7533 mL | 6.8833 mL | |
| 15 mM | 0.1836 mL | 0.9178 mL | 1.8355 mL | 4.5888 mL | |
| 20 mM | 0.1377 mL | 0.6883 mL | 1.3767 mL | 3.4416 mL | |
| 25 mM | 0.1101 mL | 0.5507 mL | 1.1013 mL | 2.7533 mL | |
| 30 mM | 0.0918 mL | 0.4589 mL | 0.9178 mL | 2.2944 mL | |
| 40 mM | 0.0688 mL | 0.3442 mL | 0.6883 mL | 1.7208 mL | |
| 50 mM | 0.0551 mL | 0.2753 mL | 0.5507 mL | 1.3767 mL | |
| 60 mM | 0.0459 mL | 0.2294 mL | 0.4589 mL | 1.1472 mL | |
| 80 mM | 0.0344 mL | 0.1721 mL | 0.3442 mL | 0.8604 mL | |
| 100 mM | 0.0275 mL | 0.1377 mL | 0.2753 mL | 0.6883 mL |
FKB04 Related Classifications
HY-169120 Related Classifications
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