FR260330
FR260330 is a selective, orally active inhibitor for inducible nitric oxide synthase (iNOS) through suppression of iNOS dimerization. FR260330 inhibits the NO accumulation in rat splenocytes and human DLD-110 cells, with IC50 of 27 and 10 nM. FR260330 ameliorates the Lipopolysaccharides (HY-D1056)-induced inflammatory diseases in rats model.
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- CAS. Nr.: 442198-67-6
- Formel: C29H28ClF3N6O4
- Molecular Weight:617.02
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Speicherung:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biologische Aktivität
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iNOS |
Chemical Information
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CAS. Nr. 442198-67-6
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Molecular Weight 617.02
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Formel C29H28ClF3N6O4
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SMILES
O=C(N1CCC(OC2=NC=NC(C(F)(F)F)=C2)CC1)CNC([C@@H](NC(/C=C/C3=CC=C(Cl)C=C3)=O)CC4=CC=CC=N4)=O
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
Please store the product under the recommended conditions in the Certificate of Analysis.
Reinheit & Dokumentation
Verweise
Calculators
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
FR260330 Related Classifications
HY-122063 Related Classifications
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