CEACAM5 - CEA cell adhesion molecule 5 Gene
Also Known as CEA; CD66e
Species: Homo sapiens
About CEACAM5
This gene has 9 transcripts (splice variants), 562 orthologues and 24 paralogues. Biased expression in colon (RPKM 540.8), appendix (RPKM 102.3) and 2 other tissues.
Summary
This gene encodes a cell surface glycoprotein that represents the founding member of the carcinoembryonic antigen (CEA) family of proteins. The encoded protein is used as a clinical biomarker for gastrointestinal cancers and may promote tumor development through its role as a cell adhesion molecule. Additionally, the encoded protein may regulate differentiation, Apoptosis, and cell polarity. This gene is present in a CEA family gene cluster on chromosome 19. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2015]
CEACAM5 Products (3)
| mRNA | Protein | Name |
|---|---|---|
| NM_001291484.3 | NP_001278413.1 | carcinoembryonic antigen-related cell adhesion molecule 5 isoform 1 preproprotein |
| NM_001308398.2 | NP_001295327.1 | carcinoembryonic antigen-related cell adhesion molecule 5 isoform 2 preproprotein |
| NM_004363.6 | NP_004354.3 | carcinoembryonic antigen-related cell adhesion molecule 5 isoform 1 preproprotein |
| Molecular Function GO Annotation | Evidence | Verweise | Source |
|---|---|---|---|
| enables GPI anchor binding |
IMP
IMP: Inferred from mutant phenotype
|
10931872 | GOA |
| enables identical protein binding |
IDA
IDA: Inferred from direct assay
|
26483485 | GOA |
| enables identical protein binding |
IPI
IPI: Inferred from physical interaction
|
10864933 | GOA |
| enables protein binding |
IPI
IPI: Inferred from physical interaction
|
27489282 | GOA |
| enables protein homodimerization activity |
IDA
IDA: Inferred from direct assay
|
18086185 | GOA |
| Biological Process GO Annotation | Evidence | Verweise | Source |
|---|---|---|---|
| involved in heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules |
IMP
IMP: Inferred from mutant phenotype
|
2803308 | GOA |
| involved in homophilic cell adhesion via plasma membrane adhesion molecules |
IMP
IMP: Inferred from mutant phenotype
|
2803308 | GOA |
| involved in homotypic cell-cell adhesion |
IDA
IDA: Inferred from direct assay
|
10864933 | GOA |
| involved in negative regulation of anoikis |
IDA
IDA: Inferred from direct assay
|
10910050 | GOA |
| involved in negative regulation of apoptotic process |
IDA
IDA: Inferred from direct assay
|
11448920 | GOA |
| involved in negative regulation of myotube differentiation |
IDA
IDA: Inferred from direct assay
|
8408226 | GOA |
| Cellular Component GO Annotation | Evidence | Verweise | Source |
|---|---|---|---|
| located in apical plasma membrane |
IDA
IDA: Inferred from direct assay
|
10436421 | GOA |
| located in basolateral plasma membrane |
IDA
IDA: Inferred from direct assay
|
15052268 | GOA |
| located in cell surface |
IDA
IDA: Inferred from direct assay
|
2317824 | GOA |
| located in membrane |
IDA
IDA: Inferred from direct assay
|
2317824 | GOA |
| located in plasma membrane |
IDA
IDA: Inferred from direct assay
|
10864933 | GOA |
CEACAM5 Protein Structure
V-set: Immunoglobulin V-set domain (39 - 140)
Ig_3: Immunoglobulin domain (146 - 219)
Ig_2: Immunoglobulin domain (239 - 318)
I-set: Immunoglobulin I-set domain (331 - 401)
Ig_2: Immunoglobulin domain (418 - 494)
Ig_3: Immunoglobulin domain (502 - 575)
Ig_2: Immunoglobulin domain (596 - 669)
- 0
- 200
- 400
- 600
- 702 a.a.
| Protein Preferred Names | Protein Names | |
|---|---|---|
|
carcinoembryonic antigen-related cell adhesion molecule 5 |
|
CEACAM5 Protein-protein interaction Information
|
Type
|
Protein Name | Protein ID | Interactor | Interactor Species | Interactor ID | Detection Method | Verweise |
|---|---|---|---|---|---|---|---|
|
Intra
|
CEACAM5 | P06731 | S | Human betacoronavirus | K0BRG7 | 27489282 | |
|
Intra
|
CEACAM5 | P06731 | CEACAM5 | Homo sapiens | P06731 | 18086185 | |
|
Intra
|
CEACAM5 | P06731 | llama single domain | Lama glama | 152143602 | 19531051 | |
|
Intra
|
CEACAM5 | P06731 | CEACAM5 | Homo sapiens | P06731 | 26483485 | |
|
Intra
|
CEACAM5 | P06731 | CEACAM5 | Homo sapiens | P06731 | 18086185 | |
|
Intra
|
CEACAM5 | P06731 | CEACAM5 | Homo sapiens | P06731 | 18086185 | |
|
Intra
|
CEACAM5 | P06731 | CEACAM1 | Homo sapiens | P13688 | 21982860 | |
|
Intra
|
CEACAM5 | P06731 | CEACAM5 | Homo sapiens | P06731 | 18086185 | |
|
Intra
|
CEACAM5 | P06731 | CEACAM5 | Homo sapiens | P06731 | 18086185 | |
|
Intra
|
CEACAM5 | P06731 | afaE3 | Escherichia coli | Q57254 | 18086185 | |
|
Intra
|
CEACAM5 | P06731 | c3 | Lama glama | 152143600 | 19531051 |
Recombinant CEACAM5 Proteins
| Art. -Nr. | Produktname | Accession | Reinheit |
|---|---|---|---|
| HY-P70675 | CEACAM5 Protein, Human (HEK293, His) | P06731-1 (K35-A685) | ≥ 95%, as determined by reducing SDS-PAGE. |
| HY-P72362 | CEACAM5 Protein, Human (Biotinylated, HEK293, His-Avi) | P06731-1 (K35-A685) | ≥ 95%, as determined by reducing SDS-PAGE. |
| HY-P72693 | CEACAM5 Protein, Human (HEK293, Fc) | P06731-1 (K35-A685) | ≥ 95%, as determined by reducing SDS-PAGE. |
| HY-P75355 | CEACAM5 Protein, Human (Biotinylated, HEK293, C-His) | NP_004354.2 (K35-A685) | ≥ 95%, as determined by reducing SDS-PAGE. |
| HY-P75356 | CEACAM5 Protein, Human (HEK293, His, solution) | NP_004354.2 (K35-A685, K364E) | ≥ 95%, as determined by reducing SDS-PAGE. |
CEACAM5 Antibodies
| Art. -Nr. | Produktname | Anwendung | Reactivity |
|---|---|---|---|
| HY-P81080 | CEA Antibody (YA917) | WB, IHC-P, ICC/IF | Human |
| HY-P83977 | CEA Antibody (YA3674) | IHC-P, ELISA | Human |
| HY-P83977A | CEA Antibody (YA3674)(PBS only) | IHC-P, ELISA | Human |
| HY-P85091 | CEA Antibody (YA4783) | WB, IHC-P, IHC-F, IF-Tissue | Human |
| HY-P85091A | CEA Antibody (YA4783)(PBS only) | WB, IHC-P, IHC-F, IF-Tissue | Human |
Related Diseases
| Diseases | Alias | |
|---|---|---|
| Bile Duct Cancer |
|
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| Lung Cancer |
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| Rectum Cancer |
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| Papillary Adenocarcinoma |
|
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| Gastrointestinal Carcinoma |
|
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| Rectosigmoid Cancer |
|
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| Esophageal Disease |
|
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| Cystadenocarcinoma |
|
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| Benign Teratoma |
|
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| Transverse Colon Cancer |
|
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| Sweat Gland Cancer |
|
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| Cecum Carcinoma |
|
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| Descending Colon Cancer |
|
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| Bile Duct Cystadenocarcinoma |
|
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| Cervical Adenocarcinoma |
|
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| Pancreatic Mucinous Cystadenoma |
|
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| Cystadenoma |
|
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| Pancreatic Cystadenocarcinoma |
|
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| Pseudomyxoma Peritonei |
|
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| Gallbladder Cancer |
|
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| Mucoepidermoid Esophageal Carcinoma |
|
|
| Colorectal Cancer |
|
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| Sigmoid Neoplasm |
|
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| Signet Ring Cell Adenocarcinoma |
|
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| Colon Adenocarcinoma |
|
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| Ureter Adenocarcinoma |
|
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| Ascending Colon Cancer |
|
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| Hepatic Flexure Cancer |
|
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| Microinvasive Gastric Cancer |
|
|
| Immature Teratoma Of Ovary |
|
|
| Large Cell Carcinoma |
|
|
| Vaccinia |
|
|
| Appendiceal Neoplasm |
|
|
| Endodermal Sinus Tumor |
|
|
| Gallbladder Papillary Carcinoma |
|
|
| Gallbladder Adenocarcinoma |
|
|
| Uterine Cervix Leukoplakia |
|
|
| Adamantinoid Basal Cell Epithelioma |
|
|
| Bile Duct Cysts |
|
|
| Tubular Adenocarcinoma |
|
|
| Lipoma Of Colon |
|
|
| Large Intestine Lipoma |
|
|
| Xanthogranulomatous Cholecystitis |
|
|
| Eccrine Sweat Gland Cancer |
|
|
| Cystic Teratoma |
|
|
| Ovarian Fetiform Teratoma |
|
|
| Malignant Acrospiroma |
|
|
| Cholangitis |
|
|
| Eccrine Papillary Adenoma |
|
|
| Mucinous Ovarian Cystadenoma |
|
|
| Malignant Syringoma |
|
|
| Krukenberg Carcinoma |
|
|
| Benign Mesothelioma |
|
|
| Rectosigmoid Junction Neoplasm |
|
|
| Mucinous Cystadenocarcinoma Of Pancreas |
|
|
| Cutaneous Mucoepidermoid Carcinoma |
|
|
| Mucinous Adenocarcinoma |
|
|
| Adenosquamous Carcinoma |
|
|
| Appendix Cancer |
|
|
| Appendix Disease |
|
|
| Eccrine Sweat Gland Neoplasm |
|
|
| Adenocarcinoma |
|
|
| Pancreatic Cancer |
|
|
| Klatskin'S Tumor |
|
|
| Thyroid Carcinoma, Familial Medullary |
|
|
| Duodenal Obstruction |
|
|
| Gastric Adenocarcinoma |
|
|
| Eccrine Mixed Tumor Of Skin |
|
|
| Gastric Fundus Cancer |
|
|
| Lung Pleomorphic Carcinoma |
|
|
| Sebaceous Breast Carcinoma |
|
|
| Chest Wall Lipoma |
|
|
| Small Intestine Cancer |
|
|
| Common Bile Duct Disease |
|
|
| Pancreatic Serous Cystadenoma |
|
|
| Ampulla Of Vater Cancer |
|
|
| Ovarian Cystadenocarcinoma |
|
|
| Liver Lipoma |
|
|
| Vulva Adenocarcinoma |
|
|
| Vulval Paget'S Disease |
|
|
| Malignant Epithelial Mesothelioma |
|
|
| Sex Cord-Gonadal Stromal Tumor |
|
|
| Gastric Cancer |
|
|
| Clear Cell Hidradenoma |
|
|
| Ovarian Mucinous Cystadenocarcinoma |
|
|
| Nodular Hidradenoma |
|
|
| Trachea Carcinoma |
|
|
| Eccrine Acrospiroma |
|
|
| Splenic Flexure Cancer |
|
|
| Thyroid Gland Cancer |
|
|
| Leukoplakia Of Penis |
|
|
| Rectal Benign Neoplasm |
|
|
| Seminal Vesicle Cystadenoma |
|
|
| Bronchus Cancer |
|
|
| Anal Canal Carcinoma |
|
|
| Bronchiolo-Alveolar Adenocarcinoma |
|
|
| Myoma |
|
|
| Acute Gonococcal Endometritis |
|
|
| Fox-Fordyce Disease |
|
|
| Biliary Tract Benign Neoplasm |
|
|
| Thyroid Gland Medullary Carcinoma |
|
|
| Hepatoid Adenocarcinoma |
|
|
| Thymus Adenocarcinoma |
|
|
| Middle East Respiratory Syndrome |
|
|
| Liver Sarcoma |
|
|
| Colonic Lymphangioma |
|
|
| Aggressive Digital Papillary Adenocarcinoma |
|
|
| Urethral Villous Adenoma |
|
|
| Acute Cholangitis |
|
|
| Hidrocystoma |
|
|
| Rectum Signet Ring Adenocarcinoma |
|
|
| Teratoma |
|
|
| Breast Cystic Hypersecretory Carcinoma |
|
|
| Eccrine Porocarcinoma |
|
|
| Prostate Signet Ring Cell Adenocarcinoma |
|
|
| Cecal Disease |
|
|
| Mesothelioma, Malignant |
|
|
| Parovarian Cyst |
|
|
| Urethral Benign Neoplasm |
|
|
| Sweat Gland Benign Neoplasm |
|
|
| Villous Adenoma |
|
|
| Cholecystolithiasis |
|
|
| Vagina Leiomyoma |
|
|
| Small Cell Cancer Of The Lung |
|
|
| Paget Disease, Extramammary |
|
|
| Mucinous Cystadenocarcinoma |
|
|
| Signet Ring Basal Cell Carcinoma |
|
|
| Ovarian Benign Neoplasm |
|
|
| Apocrine Sweat Gland Neoplasm |
|
|
| Gastrointestinal Tuberculosis |
|
|
| Biliary Papillomatosis |
|
|
| Sweat Gland Disease |
|
|
| Obstructive Jaundice |
|
|
| Vulvar Apocrine Adenocarcinoma |
|
|
| Borst-Jadassohn Intraepidermal Carcinoma |
|
|
| Tuberculous Peritonitis |
|
|
| Female Urethral Cancer |
|
|
| Hidradenoma |
|
|
| Gastric Diffuse Adenocarcinoma |
|
|
| Internal Hemorrhoid |
|
|
| Salivary Gland Carcinoma |
|
|
| Hemorrhoid |
|
|
| Adult Teratoma |
|
|
| Abdominal Tuberculosis |
|
|
| Larynx Sarcoma |
|
|
| Malignant Biphasic Mesothelioma |
|
|
| Squamous Cell Carcinoma |
|
|
| Chondroid Chordoma |
|
|
| Ovarian Cystic Teratoma |
|
|
| Mucocele Of Appendix |
|
|
| Pancreatic Foamy Gland Adenocarcinoma |
|
|
| Gastric Small Cell Carcinoma |
|
|
| Appendix Adenocarcinoma |
|
|
| Urinary Bladder Villous Adenoma |
|
|
| Adenoid Basal Cell Carcinoma |
|
|
| Mature Teratoma Of The Ovary |
|
|
| Syringoma |
|
|
| Dermoid Cyst Of Ovary |
|
|
| Vulva Cancer |
|
|
| Laryngeal Mucoepidermoid Carcinoma |
|
|
| Pancreatic Signet Ring Cell Adenocarcinoma |
|
|
| Rectum Adenocarcinoma |
|
|
| Vaginal Benign Neoplasm |
|
|
| Adenocarcinoma In Situ |
|
|
| Ovarian Cystadenoma |
|
|
| Renal Pelvis Adenocarcinoma |
|
|
| Linitis Plastica |
|
|
| Pericardial Tuberculosis |
|
|
| Breast Cancer |
|
|
| Apocrine Adenoma |
|
|
| Papillary Thymic Adenocarcinoma |
|
|
| Clear Cell Acanthoma |
|
|
| Syringocystadenoma Papilliferum |
|
|
| Choledocholithiasis |
|
|
| Ovarian Mucinous Adenocarcinoma |
|
|
| Lymphangitis |
|
|
| Microcystic Adenoma |
|
|
| Malignant Spiradenoma |
|
|
| Intrahepatic Cholangiocarcinoma |
|
|
| Secretory Meningioma |
|
|
| Hepatic Tuberculosis |
|
|
| Liver Leiomyoma |
|
|
| Esophageal Tuberculosis |
|
|
| Rectal Disease |
|
|
| Spiradenoma |
|
|
| Ovary Adenocarcinoma |
|
|
| Gallbladder Carcinoma In Situ |
|
|
| Anus Disease |
|
|
| Myoblastoma |
|
|
| Eccrine Adenocarcinoma |
|
|
| Extrapulmonary Tuberculosis |
|
|
| Liver Leiomyosarcoma |
|
|
| Pericardium Cancer |
|
|
| Papillary Adenoma |
|
|
| Cholangiocarcinoma |
|
|
| Pancreatic Serous Cystadenocarcinoma |
|
|
| Mediastinal Cancer |
|
|
| Ovarian Mucinous Neoplasm |
|
|
| Mature Teratoma |
|
|
| Liver Lymphoma |
|
|
| Bladder Adenocarcinoma |
|
|
| Gastric Body Carcinoma |
|
|
| Endocervical Carcinoma |
|
|
| Vaginal Glandular Tumor |
|
|
| Middle Ear Cholesterol Granuloma |
|
|
| Pleural Tuberculosis |
|
|
| Ovarian Germ Cell Cancer |
|
|
| Malignant Teratoma |
|
|
| Duodenum Disease |
|
|
| Nonbacterial Thrombotic Endocarditis |
|
|
| Clear Cell Basal Cell Carcinoma |
|
|
| Cholangiolocellular Carcinoma |
|
|
| Pleomorphic Carcinoma |
|
|
| Mucinous Adenofibroma |
|
|
| Ovarian Germ Cell Teratoma |
|
|
| Lung Disease |
|
|
| Pancreatoblastoma |
|
|
| Subserous Uterine Fibroid |
|
|
| Lymphohistiocytoid Mesothelioma |
|
|
| Duodenum Adenocarcinoma |
|
|
| Anal Paget'S Disease |
|
|
| Duodenum Cancer |
|
|
| Intestinal Benign Neoplasm |
|
|
| Peritoneum Cancer |
|
|
| Adenoid Squamous Cell Carcinoma |
|
|
| Multiple Endocrine Neoplasia, Type Iib |
|
|
| Endometrial Cancer |
|
|
| Lung Cancer Susceptibility 3 |
|
|
| Ovarian Serous Cystadenocarcinoma |
|
|
| Pericardial Mesothelioma |
|
|
| Fallopian Tube Serous Adenocarcinoma |
|
|
| Squamous Cell Bile Duct Carcinoma |
|
|
| Colorectal Adenocarcinoma |
|
|
| Lung Squamous Cell Carcinoma |
|
|
| Duodenum Adenoma |
|
|
| Ovarian Gonadoblastoma |
|
|
| Jejunal Cancer |
|
|
| Keratinizing Squamous Cell Carcinoma |
|
|
| Mucinous Intrahepatic Cholangiocarcinoma |
|
|
| Cervical Squamous Cell Carcinoma |
|
|
| Bile Duct Cystadenoma |
|
|
| Apocrine Adenocarcinoma |
|
|
| Granulomatous Endometritis |
|
|
| Peritoneal Mesothelioma |
|
|
| Autoimmune Pancreatitis |
|
|
| Bile Duct Mucoepidermoid Carcinoma |
|
|
| Ovarian Cancer |
|
|
| Vaginal Discharge |
|
|
| Intestinal Obstruction |
|
|
| Papillary Serous Adenocarcinoma |
|
|
| Esophagus Lymphoma |
|
|
| Colonic Benign Neoplasm |
|
|
| Cervical Serous Adenocarcinoma |
|
|
| Gallbladder Disease |
|
|
| Intrahepatic Bile Duct Adenoma |
|
|
| Gastrointestinal System Benign Neoplasm |
|
|
| Vulvar Eccrine Porocarcinoma |
|
|
| Mixed Cell Type Cancer |
|
|
| Cavernous Hemangioma |
|
|
| Lymphangioma |
|
|
| Cardiovascular Organ Benign Neoplasm |
|
|
| Esophageal Adenosquamous Carcinoma |
|
|
| Pancreas Lymphoma |
|
|
| Splenic Abscess |
|
|
| Bile Duct Disease |
|
|
| Ureter Squamous Cell Carcinoma |
|
|
| Adenosquamous Bile Duct Carcinoma |
|
|
| Hepatocellular Carcinoma |
|
|
| Retinal Melanoma |
|
|
| Thymus Small Cell Carcinoma |
|
|
| Anus Cancer |
|
|
| Small Cell Carcinoma |
|
|
| Intussusception |
|
|
| Biliary Tract Disease |
|
|
| Mammary Paget'S Disease |
|
|
| Neurofibroma Of The Esophagus |
|
|
| Endocervical Adenocarcinoma |
|
|
| Ovarian Cyst |
|
|
| Vaginal Tubulovillous Adenoma |
|
|
| Gallbladder Small Cell Carcinoma |
|
|
| Ovarian Large-Cell Neuroendocrine Carcinoma |
|
|
| Bile Duct Adenocarcinoma |
|
|
| Maxillary Sinus Benign Neoplasm |
|
|
| Splenic Tuberculosis |
|
|
| Aortic Malignant Tumor |
|
|
| Pleural Disease |
|
|
| Benign Peritoneal Mesothelioma |
|
|
| Vulvar Disease |
|
|
| Colon Leiomyosarcoma |
|
|
| Reproductive Organ Benign Neoplasm |
|
|
| Fallopian Tube Disease |
|
|
| Sublingual Gland Adenoid Cystic Carcinoma |
|
|
| Squamous Papillomatosis |
|
|
| Colorectal Adenoma |
|
|
| Polycystic Liver Disease 1 With Or Without Kidney Cysts |
|
|
| Ovarian Mixed Germ Cell Neoplasm |
|
|
| Thoracic Benign Neoplasm |
|
|
| Pulmonary Artery Leiomyosarcoma |
|
|
| Thyroid Gland Disease |
|
|
| Thyroid Dyshormonogenesis 2a |
|
|
| Vein Disease |
|
|
| Vulva Basal Cell Carcinoma |
|
|
| Cardiomyopathy, Familial Hypertrophic, 6 |
|
|
| Gummatous Syphilis |
|
|
| Rhabdomyosarcoma |
|
|
| Cervix Carcinoma |
|
|
| Malignant Ovarian Surface Epithelial-Stromal Neoplasm |
|
|
| External Ear Carcinoma |
|
|
| Esophageal Cancer |
|
|
| Lynch Syndrome |
|
|
| Breast Adenocarcinoma |
|
|
| Nasal Cavity Olfactory Neuroblastoma |
|
|
| Gastrointestinal Stromal Tumor |
|
|
| Cholangitis, Primary Sclerosing |
|
|
| Bilirubin Metabolic Disorder |
|
|
| Wilms Tumor 1 |
|
|