EEF2K - eukaryotic elongation factor 2 kinase Gene

Also Known as eEF-2K; CaMKIII; HSU93850

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 29904

About EEF2K

Cytogenetic location: 16p12.2 Genomic coordinates (GRCh38): 16:22,206,278-22,288,738 (from NCBI)

This gene has 4 transcripts (splice variants), 1 gene allele, 207 orthologues and 4 paralogues. Ubiquitous expression in skin (RPKM 21.4), fat (RPKM 10.0) and 24 other tissues.

Summary

This gene encodes a highly conserved protein kinase in the calmodulin-mediated signaling pathway that links activation of cell surface receptors to cell division. This kinase is involved in the regulation of protein synthesis. It phosphorylates eukaryotic elongation factor 2 (EEF2) and thus inhibits the EEF2 function. The activity of this kinase is increased in many cancers and may be a valid target for anti-cancer treatment. [provided by RefSeq, Jul 2008]

EEF2K Products (1)

mRNA Protein Name
NM_013302.5 NP_037434.2 eukaryotic elongation factor 2 kinase

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence Verweise Source
enables calmodulin binding IDA
IDA: Inferred from direct assay
9144159 GOA
enables elongation factor-2 kinase activity IDA
IDA: Inferred from direct assay
9144159 GOA
Biological Process GO Annotation Evidence Verweise Source
involved in protein autophosphorylation IDA
IDA: Inferred from direct assay
9144159 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

EEF2K Protein Structure

Alpha_kinase

Alpha_kinase: Alpha-kinase family (138 - 318)

Sel1

Sel1: Sel1 repeat (528 - 562)

Sel1

Sel1: Sel1 repeat (590 - 609)

Sel1

Sel1: Sel1 repeat (613 - 645)

Sel1

Sel1: Sel1 repeat (667 - 699)

  • 0
  • 200
  • 400
  • 600
  • 725 a.a.
Protein Preferred Names Protein Names

eukaryotic elongation factor 2 kinase

  • alternative protein EEF2K

EEF2K Antibodies

Art. -Nr. Produktname Anwendung Reactivity
HY-P86858 EEF2K Antibody (YA6551) WB, ICC/IF, FC Human, Mouse, Rat

Related Diseases

Diseases Alias
Lung Cancer

  • Lung Carcinoma

  • Non-Small Cell Lung Carcinoma

  • Lung Cancer, Susceptibility To

  • Lung Cancer, Protection Against

  • Adenocarcinoma Of Lung, Somatic

  • Adenocarcinoma Of Lung, Response To Tyrosine Kinase Inhibitor In

  • Nonsmall Cell Lung Cancer

  • Lung Neoplasm

  • Carcinoma Of Lung

  • Lung Non-Small Cell Carcinoma

  • Non-Small Cell Lung Cancer

  • Nsclc

  • Lung Neoplasms

  • Malignant Neoplasm Of Lung

  • Alveolar Cell Carcinoma

  • Nonsmall Cell Lung Cancer, Somatic

  • Nonsmall Cell Lung Cancer, Response To Tyrosine Kinase Inhibitor In

  • Nonsmall Cell Lung Cancer, Susceptibility To

  • Lung Cancer, Somatic

  • Lung Cancer, Resistance To

  • Cancer Of Lung

  • Cancer Of Bronchus

  • Cancer Of The Lung

  • Lung Malignancies

  • Lung Malignant Tumors

  • Malignant Lung Tumor

  • Malignant Tumor Of Lung

  • Pulmonary Cancer

  • Pulmonary Carcinoma

  • Pulmonary Neoplasms

  • Respiratory Carcinoma

  • LNCR

  • Adenocarcinoma Of Lung

  • Neoplasm Of Lung

  • Cancer Lung

  • Carcinoma Non-Small Cell Lung

  • Carcinoma, Non-Small-Cell Lung

  • Lung Cancers

  • Lung Carcinomas

  • Cancer, Lung

  • Cancer, Lung, Non-Small Cell

  • Primary Malignant Neoplasm Of Lung

  • Bronchioloalveolar Adenocarcinoma
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (13)
Art. -Nr. Produktname
Wirkung
Reinheit
Rare Diseases
HY-110096 A-484954 Inhibitor 99.57% Unkown
HY-100576 NH125 Inhibitor 99.63% Unkown
HY-146324 PROTAC eEF2K degrader-1 Activator 98.64% Unkown
HY-112393 TX-1918 Inhibitor / Unkown
HY-121828 TX-1123 Inhibitor / Unkown
HY-123024 Cefatrizine / Unkown
HY-176149 Fluoxetine-Conjugated Platinum(IV) prodrug-1 / Unkown
HY-177720 eEF2K degrader-2 / Unkown
HY-181506 TYMJ-01 / Unkown
HY-184950 eEF2K ligand-1 Ligand / Unkown
HY-RS04181 EEF2K Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS20013 Eef2k Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS26516 Eef2k Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Macaca mulatta EEF2K VGNC VGNC:72098
Felis catus EEF2K VGNC VGNC:61734
Rattus norvegicus EEF2K RGD RGD:2538
Mus musculus EEF2K MGD MGI:1195261
Bos taurus EEF2K VGNC VGNC:28336
Canis familiaris EEF2K VGNC VGNC:40210
Others EEF2K NCBI