NDUFB7 - NADH:ubiquinone oxidoreductase subunit B7 Gene
Also Known as B18; CI-B18; MC1DN39
Species: Homo sapiens
About NDUFB7
This gene has 2 transcripts (splice variants), 184 orthologues and is associated with 1 phenotype. Ubiquitous expression in fat (RPKM 29.3), heart (RPKM 25.7) and 25 other tissues.
Summary
The protein encoded by this gene is a subunit of the multisubunit NADH:ubiquinone oxidoreductase (complex I). Mammalian complex I is composed of 45 different subunits. It is located at the mitochondrial inner membrane. This protein has NADH dehydrogenase activity and oxidoreductase activity. It transfers electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone. [provided by RefSeq, Jul 2008]
NDUFB7 Products (1)
| mRNA | Protein | Name |
|---|---|---|
| NM_004146.6 | NP_004137.2 | NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 7 |
| Molecular Function GO Annotation | Evidence | Verweise | Source |
|---|---|---|---|
| enables NADH dehydrogenase (ubiquinone) activity |
IMP
IMP: Inferred from mutant phenotype
|
33502047 | GOA |
| enables protein binding |
IPI
IPI: Inferred from physical interaction
|
32296183 | GOA |
| Biological Process GO Annotation | Evidence | Verweise | Source |
|---|---|---|---|
| involved in mitochondrial respiratory chain complex I assembly |
IMP
IMP: Inferred from mutant phenotype
|
27626371 | GOA |
| Cellular Component GO Annotation | Evidence | Verweise | Source |
|---|---|---|---|
| located in mitochondrial inner membrane |
IDA
IDA: Inferred from direct assay
|
28844695 | GOA |
| located in mitochondrial intermembrane space |
IDA
IDA: Inferred from direct assay
|
21310150 | GOA |
| part of respiratory chain complex I |
IDA
IDA: Inferred from direct assay
|
12611891 | GOA |
NDUFB7 Protein Structure
NDUF_B7: NADH-ubiquinone oxidoreductase B18 subunit (NDUFB7) (38 - 103)
- 0
- 100
- 137 a.a.
| Protein Preferred Names | Protein Names | |
|---|---|---|
|
NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 7 |
|
NDUFB7 Protein-protein interaction Information
|
Type
|
Protein Name | Protein ID | Interactor | Interactor Species | Interactor ID | Detection Method | Verweise |
|---|---|---|---|---|---|---|---|
|
Intra
|
NDUFB7 | P17568 | RIPPLY1 | Homo sapiens | Q0D2K3 | 32296183 | |
|
Intra
|
NDUFB7 | P17568 | RIPPLY2 | Homo sapiens | Q5TAB7 | 32296183 | |
|
Intra
|
NDUFB7 | P17568 | RECK | Homo sapiens | Q6P9E2 | 32296183 | |
|
Intra
|
NDUFB7 | P17568 | NFKBID | Homo sapiens | Q8NI38 | 32296183 | |
|
Intra
|
NDUFB7 | P17568 | ZNF564 | Homo sapiens | Q8TBZ8 | 32296183 | |
|
Intra
|
NDUFB7 | P17568 | CCDC24 | Homo sapiens | Q8N4L8 | 32296183 | |
|
Intra
|
NDUFB7 | P17568 | TLE5 | Homo sapiens | Q08117-2 | 32296183 | |
|
Intra
|
NDUFB7 | P17568 | KRTAP10-10 | Homo sapiens | P60014 | 32296183 | |
|
Intra
|
NDUFB7 | P17568 | LMO2 | Homo sapiens | P25791-3 | 32296183 | |
|
Intra
|
NDUFB7 | P17568 | GPATCH2L | Homo sapiens | Q9NWQ4-1 | 32296183 | |
|
Intra
|
NDUFB7 | P17568 | CTNNA3 | Homo sapiens | Q9UI47-2 | 32296183 | |
|
Intra
|
NDUFB7 | P17568 | CLCNKA | Homo sapiens | P51800-3 | 32296183 | |
|
Intra
|
NDUFB7 | P17568 | ATG9A | Homo sapiens | Q7Z3C6-3 | 32296183 | |
|
Intra
|
NDUFB7 | P17568 | STRA6 | Homo sapiens | Q9BX79-6 | 32296183 | |
|
Intra
|
NDUFB7 | P17568 | ANKRD36B | Homo sapiens | Q8N2N9-4 | 32296183 | |
|
Intra
|
NDUFB7 | P17568 | AGBL2 | Homo sapiens | Q5U5Z8-3 | 32296183 | |
|
Intra
|
NDUFB7 | P17568 | WUGSC:H_DJ0726N20.gs.b | Homo sapiens | Q9Y6T4 | 32296183 | |
|
Intra
|
NDUFB7 | P17568 | RCOR3 | Homo sapiens | Q9P2K3-2 | 32296183 | |
|
Intra
|
NDUFB7 | P17568 | RCOR3 | Homo sapiens | Q9P2K3-2 | 32296183 | |
|
Intra
|
NDUFB7 | P17568 | MKRN3 | Homo sapiens | Q13064 | 32296183 | |
|
Intra
|
NDUFB7 | P17568 | TFAP4 | Homo sapiens | Q01664 | 32296183 | |
|
Intra
|
NDUFB7 | P17568 | NFKBIB | Homo sapiens | Q15653 | 32296183 | |
|
Intra
|
NDUFB7 | P17568 | ZNF330 | Homo sapiens | Q9Y3S2 | 32296183 | |
|
Intra
|
NDUFB7 | P17568 | CCNC | Homo sapiens | P24863 | 32296183 | |
|
Intra
|
NDUFB7 | P17568 | CDCA7L | Homo sapiens | Q96GN5 | 32296183 | |
|
Intra
|
NDUFB7 | P17568 | ZNF587 | Homo sapiens | Q96SQ5 | 32296183 | |
|
Intra
|
NDUFB7 | P17568 | FAM90A1 | Homo sapiens | Q86YD7 | 32296183 | |
|
Intra
|
NDUFB7 | P17568 | SPRED2 | Homo sapiens | Q7Z698 | 32296183 | |
|
Intra
|
NDUFB7 | P17568 | FAM161B | Homo sapiens | Q96MY7 | 32296183 | |
|
Intra
|
NDUFB7 | P17568 | CINP | Homo sapiens | Q9BW66 | 32296183 | |
|
Intra
|
NDUFB7 | P17568 | ZNF417 | Homo sapiens | Q8TAU3 | 32296183 | |
|
Intra
|
NDUFB7 | P17568 | CHIC2 | Homo sapiens | Q9UKJ5 | 32296183 | |
|
Intra
|
NDUFB7 | P17568 | ENKD1 | Homo sapiens | Q9H0I2 | 32296183 | |
|
Intra
|
NDUFB7 | P17568 | GEM | Homo sapiens | P55040 | 32296183 | |
|
Intra
|
NDUFB7 | P17568 | CDKN2D | Homo sapiens | P55273 | 32296183 | |
|
Intra
|
NDUFB7 | P17568 | MAGOHB | Homo sapiens | Q96A72 | 32296183 | |
|
Intra
|
NDUFB7 | P17568 | SCNM1 | Homo sapiens | Q9BWG6 | 32296183 | |
|
Intra
|
NDUFB7 | P17568 | AIRIM | Homo sapiens | Q9NX04 | 32296183 |
NDUFB7 Antibodies
| Art. -Nr. | Produktname | Anwendung | Reactivity |
|---|---|---|---|
| HY-P811045 | NDUFB7 Antibody | WB, IHC-P | Human, Mouse, Rat |
Related Diseases
| Diseases | Alias | |
|---|---|---|
| Mitochondrial Disorder Due To A Defect In Assembly Or Maturation Of The Respiratory Chain Complexes |
|
|
| Mitochondrial Complex Iii Deficiency |
|
|
| Mitochondrial Complex V Deficiency, Nuclear Type 3 |
|
|
| Mitochondrial Complex I Deficiency, Nuclear Type 1 |
|
|
| Leigh Syndrome |
|
|
Orthologs Information
| Species | Symbol | Source | ID |
|---|---|---|---|
| Felis catus | NDUFB7 | VGNC | VGNC:68443 |
| Canis familiaris | NDUFB7 | VGNC | VGNC:43705 |
| Bos taurus | NDUFB7 | VGNC | VGNC:31966 |
| Mus musculus | NDUFB7 | MGD | MGI:1914166 |
| Rattus norvegicus | NDUFB7 | RGD | RGD:1308550 |
| Others | NDUFB7 | NCBI |