country

Change Language

EN - English
FR - Français
DE - Deutsch
ES - Español
JA - 日本語
KO - 한국어

Product Name	Size / Unit Price	Qty

Total: USD 0.00 Checkout

SLC30A4 - solute carrier family 30 member 4 Gene

Also Known as ZNT4; znT-4

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 7782

About SLC30A4

Cytogenetic location: 15q21.1 Genomic coordinates (GRCh38): 15:45,479,606-45,522,755 (from NCBI)

This gene has 2 transcripts (splice variants), 204 orthologues and 8 paralogues. Biased expression in prostate (RPKM 22.0), testis (RPKM 4.0) and 12 other tissues.

Summary

Zinc is the second most abundant trace metal in the human body. It is an essential element, serving both a structural role, as in the formation of zinc fingers in DNA-binding proteins, and a catalytic role in metalloenzymes, such as pancreatic carboxypeptidases (e.g., MIM 114852), alkaline phosphatases (e.g., MIM 171760), various dehydrogenases, and superoxide dismutases (e.g., MIM 147450). SLC30A4, or ZNT4, belongs to the ZNT family of zinc transporters. ZNTs are involved in transporting zinc out of the cytoplasm and have similar structures, consisting of 6 transmembrane domains and a histidine-rich cytoplasmic loop (Huang and Gitschier, 1997 [PubMed 9354792]).[supplied by OMIM, Mar 2008]

SLC30A4 Products (2)

mRNA	Protein	Name
NM_001321036.2	NP_001307965.1	zinc transporter 4 isoform 2
NM_013309.6	NP_037441.2	zinc transporter 4 isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Verweise	Source
enables protein binding	IPI IPI: Inferred from physical interaction	25657003	GOA
enables zinc ion transmembrane transporter activity	IDA IDA: Inferred from direct assay	17349999	GOA

Biological Process GO Annotation	Evidence	Verweise	Source
involved in response to toxic substance	IDA IDA: Inferred from direct assay	17575980	GOA
involved in zinc ion import into lysosome	IDA IDA: Inferred from direct assay	17349999	GOA
involved in zinc ion transmembrane transport	IDA IDA: Inferred from direct assay	19521526	GOA

Cellular Component GO Annotation	Evidence	Verweise	Source
located in cytoplasm	IDA IDA: Inferred from direct assay	17349999	GOA
located in late endosome	IDA IDA: Inferred from direct assay	17349999	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

SLC30A4 Protein Structure

Cation_efflux

0
100
200
300
400
429 a.a.

Protein Preferred Names	Protein Names
zinc transporter 4	solute carrier family 30 (zinc transporter), member 4

SLC30A4 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Verweise
Intra	SLC30A4	O14863	SLC30A3	Homo sapiens	Q99726	BiFC	25657003
Intra	SLC30A4	O14863	SLC30A3	Homo sapiens	Q99726	Anti Tag CoIP	26728129
Intra	SLC30A4	O14863	CMTM5	Homo sapiens	Q96DZ9-2	Validated Y2H	32296183
Intra	SLC30A4	O14863	SLC30A10	Homo sapiens	Q6XR72	Crosslink	26728129
Intra	SLC30A4	O14863	SLC30A10	Homo sapiens	Q6XR72	Anti Tag CoIP	26728129
Intra	SLC30A4	O14863	TMEM60	Homo sapiens	Q9H2L4	Validated Y2H	32296183
Intra	SLC30A4	O14863	TNF	Homo sapiens	P01375	Validated Y2H	32296183
Intra	SLC30A4	O14863	CLN6	Homo sapiens	Q9NWW5	Validated Y2H	32296183
Intra	SLC30A4	O14863	NSG1	Homo sapiens	P42857	Validated Y2H	32296183
Intra	SLC30A4	O14863	IER3IP1	Homo sapiens	Q9Y5U9	Validated Y2H	32296183
Intra	SLC30A4	O14863	FZD7	Homo sapiens	O75084	Validated Y2H	32296183
Intra	SLC30A4	O14863	SERP2	Homo sapiens	Q8N6R1	Validated Y2H	32296183
Intra	SLC30A4	O14863	LEPROTL1	Homo sapiens	O95214	Validated Y2H	32296183
Intra	SLC30A4	O14863	YIPF6	Homo sapiens	Q96EC8	Validated Y2H	32296183
Intra	SLC30A4	O14863	SLC30A2	Homo sapiens	Q9BRI3	BiFC	25657003
Intra	SLC30A4	O14863	TMEM100	Homo sapiens	Q9NV29	Validated Y2H	32296183
Intra	SLC30A4	O14863	BTN2A2	Homo sapiens	Q8WVV5	Validated Y2H	32296183
Cross	SLC30A4	O14863	Tfrc	Rattus norvegicus	Q99376	Anti Tag CoIP	26728129

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases	Alias
Acrodermatitis Enteropathica, Zinc-Deficiency Type	Acrodermatitis Enteropathica AEZ Enteropathica Brandt Syndrome Ae Acrodermatitis Enteropathica Zinc Deficiency Type Danbolt-Cross Syndrome Acrodermatitis Enteropathica, Zinc Deficiency Type Inherited Zinc Deficiency Acrodermatitis Enteropathica, Zinc Deficiency Danbolt-Closs Syndrome Primary Zinc Malabsorption Syndrome
Acrodermatitis
Ehlers-Danlos Syndrome, Spondylodysplastic Type, 3	Spondylocheirodysplasia, Ehlers-Danlos Syndrome-Like Scd-Eds EDSSPD3 Ehlers-Danlos Syndrome Spondylodysplastic Type 3 Ehlers-Danlos Syndrome, Spondylocheirodysplastic Type Slc39a13-Related Spondylodysplastic Ehlers-Danlos Syndrome Slc39a13-Related Speds Slc39a13-Related Spondylodysplastic Eds Spondylocheirodysplastic Ehlers-Danlos Syndrome Speds-Slc39a13 Ehlers-Danlos Syndrome-Like Spondylocheirodysplasia Ehlers-Danlos Syndrome, Spondylodysplastic, Type 3
Mucinous Stomach Adenocarcinoma	Mucinous Adenocarcinoma Of The Stomach Mucinous Gastric Adenocarcinoma

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Art. -Nr.	Produktname	Wirkung	Reinheit	Rare Diseases
HY-RS13182	SLC30A4 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	SLC30A4	VGNC	VGNC:49968
Felis catus	SLC30A4	VGNC	VGNC:65310
Mus musculus	SLC30A4	MGD	MGI:1345282
Rattus norvegicus	SLC30A4	RGD	RGD:619750
Canis familiaris	SLC30A4	VGNC	VGNC:46349
Macaca mulatta	SLC30A4	VGNC	VGNC:77454
Others	SLC30A4	NCBI