URI1 - URI1 prefoldin like chaperone Gene

Also Known as RMP; URI; NNX3; C19orf2; PPP1R19

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 8725

About URI1

Cytogenetic location: 19q12 Genomic coordinates (GRCh38): 19:29,923,657-30,016,612 (from NCBI)

This gene has 13 transcripts (splice variants) and 213 orthologues. Ubiquitous expression in thyroid (RPKM 23.9), testis (RPKM 18.7) and 25 other tissues.

Summary

This gene encodes member of the prefoldin family of molecular chaperones. The encoded protein functions as a scaffolding protein and plays roles in ubiquitination and transcription, in part though interactions with the RNA polymerase II subunit RPB5. This gene may play a role in multiple malignancies including ovarian Cancer and hepatocellular carcinoma. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene, and a pseudogene of this gene is located on the long arm of chromosome 22. [provided by RefSeq, Nov 2011]

URI1 Products (2)

mRNA	Protein	Name
NM_001252641.2	NP_001239570.1	unconventional prefoldin RPB5 interactor 1 isoform c
NM_003796.3	NP_003787.2	unconventional prefoldin RPB5 interactor 1 isoform a

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Verweise	Source
enables RNA polymerase II complex binding	IDA IDA: Inferred from direct assay	9819440	GOA
enables chromatin binding	IDA IDA: Inferred from direct assay	21730289	GOA
enables phosphoprotein binding	IPI IPI: Inferred from physical interaction	20864032	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	12737519	GOA
enables transcription corepressor activity	IDA IDA: Inferred from direct assay	12737519	GOA
enables transcription corepressor activity	IMP IMP: Inferred from mutant phenotype	9819440	GOA

Biological Process GO Annotation	Evidence	Verweise	Source
involved in cellular response to growth factor stimulus	IDA IDA: Inferred from direct assay	17936702	GOA
involved in cellular response to steroid hormone stimulus	IDA IDA: Inferred from direct assay	21730289	GOA
involved in negative regulation of intrinsic apoptotic signaling pathway	IMP IMP: Inferred from mutant phenotype	17936702	GOA
involved in negative regulation of phosphatase activity	IMP IMP: Inferred from mutant phenotype	17936702	GOA
involved in negative regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	12737519	GOA
involved in regulation of cell growth	IDA IDA: Inferred from direct assay	21730289	GOA
involved in regulation of transcription by RNA polymerase II	IMP IMP: Inferred from mutant phenotype	9819440	GOA
involved in response to virus	IMP IMP: Inferred from mutant phenotype	9819440	GOA

Cellular Component GO Annotation	Evidence	Verweise	Source
part of RPAP3/R2TP/prefoldin-like complex	IPI IPI: Inferred from physical interaction	31738558	GOA
located in cytoplasm	IDA IDA: Inferred from direct assay	15367675	GOA
located in nucleus	IDA IDA: Inferred from direct assay	15367675	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

URI1 Protein Structure

Prefoldin

0
100
200
300
400
459 a.a.

Protein Preferred Names	Protein Names
unconventional prefoldin RPB5 interactor 1	RNA polymerase II subunit 5-mediating protein

URI1 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Verweise
Intra	URI1	O94763	GTF2F2	Homo sapiens	P13984	Pull Down	12737519
Cross	URI1	O94763	Esr1	Mus musculus	P19785	Anti Bait CoIP	25453901
Intra	URI1	O94763	PPP1CC	Homo sapiens	P36873	Anti Bait CoIP	27505673
Intra	URI1	O94763	PPP1CC	Homo sapiens	P36873	Anti Bait CoIP	21397856
Intra	URI1	O94763	RPAP3	Homo sapiens	Q9H6T3	Lumier	25036637
Intra	URI1	O94763	PFDN2	Homo sapiens	Q9UHV9	Anti Bait CoIP	15923622
Intra	URI1	O94763	POLR2E	Homo sapiens	P19388	Anti Bait CoIP	15923622
Intra	URI1	O94763	GTF2F1	Homo sapiens	P35269	Pull Down	12737519
Intra	URI1	O94763	OGT	Homo sapiens	O15294	Pull Down	27505673
Intra	URI1	O94763	OGT	Homo sapiens	O15294	Anti Bait CoIP	27505673
Cross	URI1	O94763	Ahr	Mus musculus	P30561	Anti Bait CoIP	25453901

Cross: Cross-species interaction Intra: Intraspecies interaction

URI1 Antibodies

Art. -Nr.	Produktname	Anwendung	Reactivity
HY-P81462	URI1 Antibody (YA1207)	IHC-P	Human
HY-P81462A	URI1 Antibody (YA1207)(PBS only)	IHC-P	Human
HY-P87969	URI1 Antibody	WB, IHC-P	Human, Mouse

Related Diseases

Diseases	Alias
Ovarian Cancer	Ovarian Carcinoma Ovarian Neoplasm Malignant Tumour Of Ovary Cancer Of The Ovary Epithelial Ovarian Cancer Neoplasm Of Ovary Ovarian Neoplasms Ovarian Cancers Malignant Neoplasm Of Ovary Primary Malignant Neoplasm Of Ovary Ovarian Cancer, Somatic Malignant Ovarian Tumor Ovary Neoplasm Primary Ovarian Cancer Tumor Of The Ovary Malignant Neoplasm Of The Ovary Malignant Tumor Of The Ovary Ovarian Malignant Tumor OC Ovarian Carcinomas Cancer, Ovarian Cancer Of Ovary Ovary Cancer Ca Ovary
Hypermobility Of Coccyx	Coccygeal Hypermobility Syndrome Hypermobility Of The Coccyx
Klippel-Feil Syndrome 3
Prostate Cancer	Prostate Carcinoma Prostate Cancer, Familial Prostate Neoplasm Prostate Cancer, Somatic Prostate Cancer, Susceptibility To Prostatic Cancer Prostatic Neoplasms Hereditary Prostate Cancer Prostatic Neoplasm Cancer Of Prostate Carcinoma Of Prostate Familial Prostate Cancer Familial Prostate Carcinoma Malignant Tumor Of Prostate Malignant Neoplasm Of Prostate Prostate Cancer, Familial, Susceptibility To Malignant Tumor Of The Prostate Ngp - New Growth Of Prostate Tumor Of The Prostate Prostate Cancer, Hereditary Cancer Of The Prostate Malignant Neoplasm Of The Prostate Prostatic Carcinoma PC Prca Cancer, Prostate Malignant Prostatic Tumour Malignant Tumour Of Prostate Primary Prostate Cancer Primary Malignant Neoplasm Of Prostate Prostate Gland Cancer
Neurodegeneration With Brain Iron Accumulation 4	NBIA4 Mpan Mitochondrial Protein-Associated Neurodegeneration Nbia Due To C19orf12 Mutation Neurodegeneration With Brain Iron Accumulation Due To C19orf12 Mutation Neurodegeneration With Brain Iron Accumulation Type 4 Mitochondrial Membrane Protein Associated Neurodegeneration Neurodegeneration, With Brain Iron Accumulation, Type 4
Hepatocellular Carcinoma	Liver Cancer Primary Liver Cancer HCC Hepatoma Malignant Neoplasm Of Liver Liver Neoplasms Cancer, Hepatocellular Liver Cell Carcinoma Lcc Hepatoblastoma, Somatic Hepatic Cancer Primary Malignant Neoplasm Of Liver Rare Tumor Of Liver And Intrahepatic Biliary Tract Hepatocellular Carcinoma, Somatic Hepatocellular Carcinoma, Childhood Type, Somatic Hepatocellular Cancer, Somatic Ca Liver - Primary Hepatic Neoplasm Malignant Hepato-Biliary Neoplasm Malignant Neoplasm Of Liver, Not Specified As Primary Or Secondary Malignant Neoplasm Of Liver, Primary Malignant Tumor Of Liver Neoplasm Of Liver Non-Resectable Primary Hepatic Malignant Neoplasm Resectable Malignant Neoplasm Of Liver Resectable Malignant Neoplasm Of The Liver Primary Liver Carcinoma Primary Malignant Liver Neoplasm Primary Cancer Of Liver Primary Tumor Of The Liver Rare Tumor Of Liver And Ibt Hepatocellular Cancer Neoplasm Of The Liver Carcinoma, Hepatocellular Hepatomas Liver Neoplasm Liver Carcinoma Liver And Intrahepatic Biliary Tract Carcinoma Malignant Hepatobiliary Neoplasm Adult Primary Hepatocellular Carcinoma Hepatoblastoma Carcinoma Of Liver Malignant Liver Tumour Malignant Hepatic Tumour

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Approval
Pre-clinical Phase

Approval

Bioactive Molecules (2)

Art. -Nr.	Produktname	Wirkung	Reinheit	Rare Diseases
HY-A0161A	Chlophedianol hydrochloride		99.67%	Unkown
HY-A0161	Chlophedianol		/	Unkown

Pre-clinical Phase

Bioactive Molecules (2)

Art. -Nr.	Produktname	Wirkung	Reinheit	Rare Diseases
HY-A0161S	Chlophedianol-13C6		/	Unkown
HY-RS15507	URI1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	URI1	VGNC	VGNC:36698
Mus musculus	URI1	MGD	MGI:1342294
Macaca mulatta	URI1	VGNC	VGNC:78918
Canis familiaris	URI1	VGNC	VGNC:48166
Felis catus	URI1	VGNC	VGNC:66853
Rattus norvegicus	URI1	RGD	RGD:1310358
Others	URI1	NCBI