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GLPG1205

10 Cited Publications
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Based on 10 publication(s) in Google Scholar

GLPG1205 is potent, selective and orally active GPR84 (a G-protein-coupled receptor) antagonist with a favorable PK/PD profile. GLPG1205 has anti-inflammatory activity and is used for the treatment of pulmonary fibrosis. GLPG1205 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

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  • Reinheit: 99.94%
  • CAS. Nr.: 1445847-37-9
  • Formel: C22H22N2O4
  • Molecular Weight:378.42
  • Speicherung:
    Powder   -20°C, 3 years , 4°C, 2 years ; In solvent   -80°C, 2 years , -20°C, 1 year
  • GLPG1205 Chemical Structure
    GLPG1205 Chemical Structure
  • Experimental Validation Results for GLPG1205
  • Experimental Validation Results for GLPG1205
  • Experimental Validation Results for GLPG1205
  • Experimental Validation Results for GLPG1205
  • Experimental Validation Results for GLPG1205
CAS. Nr.: 1445847-37-9
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Cell Proliferation/Viability AssayBio/Physico-chemical AssayIn Vivo Efficacy StudyHistological Imaging/StainingWB
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  • GLPG1205 Chemical Structure
    GLPG1205 Chemical Structure
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    GLPG1205 purchased from MedChemExpress. Usage Cited in: Cancer Immunol Res. 2026 Jan 20. [Abstract]

    Customer Validation
     Representative histogram and average proliferation from five independent biological replicates. Naïve CD8+ T cells were labeled with CFSE, activated, and treated for 72 hours. The results showed that the addition of GPR84 antagonist GLPG1205 (72 h) during activation resulted in a significant, dose-dependent increase in proliferation at 3 μmol/L (39.3%) and 10 μmol/L (71.7%).

  • 1/16

    GLPG1205 purchased from MedChemExpress. Usage Cited in: Cancer Immunol Res. 2026 Jan 20. [Abstract]

    Customer Validation
     Average tumor volumes and associated spider plots of B16-F10 tumor-bearing mice. Mice were administered a sham treatment or adoptively transferred activated pmel CD8+ T cells pretreated with DMSO or 10 μmol/L GLPG1205. Displayed results are obtained from one significant experiment. The results showed that pmel CD8+ T cells that were activated and treated with 10 μmol/L GLPG1205 prior to adoptive transfer elicited the best antitumor response, significantly better than the DMSO positive control or sham.

  • 1/16

    GLPG1205 purchased from MedChemExpress. Usage Cited in: Mol Med. 2025 May 14;31(1):187. [Abstract]

    Customer Validation
     WT mice were injected with Con A (15 mg/kg) for 1 h, treated with GLPG1205 or vehicle control by oral gavage, Serum ALT and AST levels were measured. n = 3–7 mice per group. The results showed that compared with the vehicle control group, serum ALT and AST levels were significantly reduced in the GLPG1205-treated mice, indicating that GLPG1205 effectively attenuated Con A-induced liver injury.

  • 1/16

    GLPG1205 purchased from MedChemExpress. Usage Cited in: Mol Med. 2025 May 14;31(1):187. [Abstract]

    Customer Validation
     WT mice were injected with Con A (15 mg/kg) for 1 h, treated with GLPG1205 or vehicle control by oral gavage. H&E staining was performed to assess liver tissue damage. The results showed that the area of ​​liver injury in the GLPG1205 group was significantly smaller than that in the vehicle control group.

  • 1/16

    GLPG1205 purchased from MedChemExpress. Usage Cited in: Mol Med. 2025 May 14;31(1):187. [Abstract]

    Customer Validation
     WT mice were injected with Con A (15 mg/kg) for 1 h, and treated with GLPG1205 or vehicle control by oral gavage. Bone marrow-derived macrophages (BMDMs) were pretreated with GLPG1205 for 1 h, followed by Con A treatment at 0 h, 0.5 h, 1 h, and 2 h. Western blotting was used to measure the expression of proteins involved in the STAT3, MAPK, and NF-κB signaling pathways. The results showed that, compared with the GLPG1205 group, the expression levels of p-STAT3, p-ERK, p-JNK, p-p38, and p-p65 were significantly elevated in the vehicle control group (Vehicle group).

  • GLPG1205