GNF-8625
GNF-8625 is a broad-spectrum TRK inhibitor that can combine with Thalidomide to form a PROTAC degrader. The IC50 of GNF-8625 for inhibiting TRKA, TRKB, and TRKC are 0.8 nM, 22 nM, and 5.4 nM, respectively.
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- CAS. Nr.: 1196546-33-4
- Formel: C31H30FN7O
- Molecular Weight:535.61
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Speicherung:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biologische Aktivität
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Biologische Aktivität
Beschreibung
Cellular Effect
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| KM12 | IC50 |
16 nM
Compound: 4; GNF-8625
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Antiproliferative activity against human KM12 cells assessed as reduction in cell viability measured after 3 days by Celltiter-Glo assay
Antiproliferative activity against human KM12 cells assessed as reduction in cell viability measured after 3 days by Celltiter-Glo assay
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[PMID: 33058680] |
| KM12 | IC50 |
46.7 nM
Compound: GNF-8625
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Antiproliferative activity against human KM12 cells expressing TPM3-TRKA assessed as reduction in cell viability measured after 3 days by Celltiter-Glo assay
Antiproliferative activity against human KM12 cells expressing TPM3-TRKA assessed as reduction in cell viability measured after 3 days by Celltiter-Glo assay
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[PMID: 32550985] |
Chemical Information
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CAS. Nr. 1196546-33-4
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Molecular Weight 535.61
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Formel C31H30FN7O
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SMILES
FC1=CC=CC([C@@H]2N(CCC2)C3=NN4C(C5=CC=CC(C6=CC=NC(N7CCC(CC7)O)=C6)=N5)=CN=C4C=C3)=C1
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
Please store the product under the recommended conditions in the Certificate of Analysis.
Protokoll
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Cell Cytotoxicity Assay
Cytotoxicity assays are usually based on the assessment of cell membrane damage, which can also be indirectly detected by measuring cell viability. Detection methods include MTT assay, CKK-8 assay, LDH assay and ATP assay, etc.
Reinheit & Dokumentation
Verweise
Calculators
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
GNF-8625 Related Classifications
HY-118271 Related Classifications
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